9.3. INCAWrapper validation case medium size model

In this notebook, we use the INCAWrapper to fit a simulated data. This notebook serves as an integration test the INCAWrapper that can be run when changes are made to the codebase to ensure that the INCAWrapper performs consistently. Furthermore, this case act as a validation case the show that the INCAWrapper actually works and that it is capable of estimating correct flux distribution from simulated data.

This notebook is not meant as a tutorial and therefore code description is a bit more sparse. For a proper tutorial see the other examples at https://incawrapper.readthedocs.io/en/latest/examples/index.html.

The model we use is from Alagesan, S., Minton, N.P. & Malys, N. 13C-assisted metabolic flux analysis to investigate heterotrophic and mixotrophic metabolism in Cupriavidus necator H16. Metabolomics 14, 9 (2018). https://doi.org/10.1007/s11306-017-1302-z, which is also used for one of the tutorials.

The simulation mimics a two parallel experiment where C. necator is grown with different labelled fructose and labelled glycerol. We simulated MS measurements of the amino acids and a few exchanges fluxes are measured. To increase the information about the systems we simulate measurements of CO2 exchange flux. To do this we added one additional reaction to the original model, i.e. CO2 -> CO2.ext. For more details about the simulation see the simulation script.

[1]:
import pandas as pd
import numpy as np
import dotenv
import ast
import pandera as pa
import incawrapper
from incawrapper import utils
from incawrapper import visualization
import pathlib
import matplotlib.pyplot as plt
import pytest
[2]:
# import environment variables
INCA_base_directory = dotenv.get_key(dotenv.find_dotenv(), "INCA_base_directory")
[3]:
# set up path to data
working_dir = pathlib.Path(dotenv.find_dotenv()).parent
data_directory = working_dir / 'docs' / 'examples' / 'Literature data' / 'Cupriavidus necator  Alagesan 2017' / 'simulated_data'
results_file = data_directory / 'fit_simulated_fructose.mat'
[4]:
# Reading the reactions, tracers, and simulated measurements
rxn = pd.read_csv(data_directory / 'reactions_processed.csv')
tracers = pd.read_csv(
    data_directory / 'tracer_info.csv',
    converters={"atom_ids": ast.literal_eval, "atom_mdv": ast.literal_eval}
)
flux_measurements = pd.read_csv(data_directory / 'flux_measurements_no_noise.csv')
mdv_measurements = pd.read_csv(
    data_directory / 'mdv_no_noise.csv',
    converters={"labelled_atom_ids": ast.literal_eval}
)

Looking at the traces dataframe, we can see the design of the two simulated parallel experiments

[25]:
tracers
[25]:
experiment_id met_id tracer_id atom_ids atom_mdv enrichment
0 simulation1 FRU.ext D-[1-13C]fructose [1] [0.0, 1.0] 1
1 simulation1 GLY.ext [1,2-13C]glycerol [1, 2] [0.0, 1.0] 1
2 simulation2 FRU.ext [1,6-13C]fructose [1, 6] [0.0, 1.0] 1
3 simulation2 GLY.ext [1,2-13C]glycerol [1, 2] [0.0, 1.0] 1

We will now setup and run INCA.

[7]:
script = incawrapper.create_inca_script_from_data(
    reactions_data=rxn,
    tracer_data=tracers,
    flux_measurements=flux_measurements,
    ms_measurements=mdv_measurements,
    experiment_ids=["simulation1", "simulation2"],
)

script.add_to_block(
    "options",
    incawrapper.define_options(
        fit_starts=50,
        sim_ss=True,
        sim_na=True,
        sim_more=True,
    )
)
script.add_to_block(
    "runner",
    incawrapper.define_runner(
        output_filename=results_file,
        run_estimate=True,
        run_continuation=True,
        run_simulation=True,
    )
)
[8]:
incawrapper.run_inca(
    inca_script=script,
    INCA_base_directory=INCA_base_directory,
)
INCA script saved to /var/folders/z6/mxpxh4k56tv0h0ff41vmx7gdwtlpvp/T/tmprvxgfgwr/inca_script.m.
Starting MATLAB engine...

ms_simulation1 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation1 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation1 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation1 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation1 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation1 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation1 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation1 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation1 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation1 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation1 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation1 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation1 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation1 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation1 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation1 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation1 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation1 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation1 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation1 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation1 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation1 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation1 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation2 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation2 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation2 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation2 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation2 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation2 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation2 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation2 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation2 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation2 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation2 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation2 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation2 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation2 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation2 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation2 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation2 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation2 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation2 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation2 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation2 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation2 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


ms_simulation2 = 1x23 msdata object

fields: atoms  id  [idvs]  more  on  state

Alanine232 Alanine260 Asparticacid302 Asparticacid390 Asparticacid418 Glutamicacid330 Glutamicacid432 Glycine218 Glycine246 Histidine338 Histidine440 Isoleucine274 Leucine274 Methionine320 Phenylalanine302 Phenylalanine308 Phenylalanine336 Serine362 Serine390 Threonine376 Threonine404 Valine260 Valine288


m = 1x1 model object

fields: [expts]  [mets]  notes  [options]  [rates]  [states]

        60 reactions (75 fluxes)
        55 states (33 balanced, 2 source, 20 sink and 0 unbalanced)
        53 metabolites
        2 experiments


                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0       1.06225e+06
     1       1.02512e+06         0.144     -1.02e+05       0.91001
     2            975367         0.282     -6.19e+04       0.91001
     3            965684         0.069     -5.92e+04       0.91001
     4            950348         0.153     -3.43e+04       0.91001
     5            936144         0.241     -1.48e+04       0.91001
     6            925272             1           246       0.91001
     7            743455             1     -8.24e+04       1.05695
     8            444702         0.378     -2.91e+05      0.704553
     9            322461         0.345     -1.37e+05      0.704553
    10            255325         0.452     -5.17e+04      0.704553
    11            224471             1          -833      0.704553
    12            223926             1         -66.3      0.234851
    13            223899             1         -3.18     0.0782837
    14            223899         0.146        -0.977     0.0260946
    15            223898             1        -0.187     0.0260946
    16            223898             1       -0.0231    0.00869819
    17            223897             1        -0.117     0.0028994
    18            223896         0.141         -5.42   0.000966466
    19            223896       0.00979        -0.453   0.000966466
    20            223895             1        0.0482   0.000966466
    21            224385         0.628      7.43e+03   0.000534328
    22            224237         0.893      6.21e+03    0.00106866
    23            224368         0.893      6.72e+03    0.00427462
    24            224393         0.897      6.98e+03      0.034197
    25            224622         0.925      9.49e+03      0.273576
    26            224152             1      3.91e+03       2.18861
    27            223559             1         -3.45       17.5089
    28            223526         0.497           -21       5.83628
    29            223515         0.587         -5.83       5.83628
    30            223512             1        -0.435       5.83628
    31            223512             1       -0.0339       1.94543
    32            223511        0.0389         -8.28      0.648476
    33            223505         0.498          -3.6      0.648476
    34            223503             1        -0.379      0.648476
    35            223502             1       -0.0828      0.216159
    36            223502             1      -0.00812     0.0720529
    37            223502             1     -0.000794     0.0240176

 Optimization terminated: Constrained optimum found.
 Parameters converged to within tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0            976810
     1            976808      1.07e-05     -8.63e+04      0.489906
     2            976803       2.7e-05     -8.63e+04      0.489906
     3            976786      9.77e-05     -8.63e+04      0.489906
     4            976576       0.00122     -8.59e+04      0.489906
     5            973806        0.0165     -8.16e+04      0.489906
     6            973561       0.00147     -8.27e+04      0.489906
     7            968750        0.0313     -7.12e+04      0.489906
     8            968744      3.47e-05     -7.85e+04      0.489906
     9            960089         0.071     -4.83e+04      0.489906
    10            948018         0.152     -2.73e+04      0.489906
    11            942075        0.0746     -3.63e+04      0.489906
    12            910461         0.324     -6.17e+04      0.489906
    13            891282        0.0146     -6.45e+05      0.489906
    14            822616        0.0512      1.73e+06      0.489906
    15            816571        0.0119     -2.51e+05      0.489906
    16            811957       0.00416     -5.51e+05      0.489906
    17            811874       0.00355     -1.89e+04      0.489906
    18            782442        0.0473     -2.97e+05      0.489906
    19            159764         0.819     -1.72e+05      0.489906
    20            122861        0.0973     -1.68e+05      0.489906
    21           34112.2         0.471     -4.77e+04      0.489906
    22             30042         0.197      1.84e+04      0.489906
    23           12782.2             1          -638      0.489906
    24           12882.5             1      1.15e+03      0.176497
    25             12883             1      1.15e+03      0.352993
    26           12886.2             1      1.15e+03       1.41197
    27           12916.5             1      1.18e+03       11.2958
    28           13181.9             1       1.4e+03       90.3663
    29           14044.6         0.284      5.76e+03        722.93
    30           13042.8          0.27       1.3e+03       5783.44
    31           12390.6             1          -150       46267.5
    32           12521.1             1           214       15422.5
    33           11826.5             1          -240         30845
    34           11359.5         0.226          -656       10281.7
    35           11388.3             1           135       10281.7
    36           11330.3         0.284         -36.7       20563.3
    37           11213.9             1         -39.1       20563.3
    38           11393.7             1           286       6854.45
    39             11369             1           291       13708.9
    40           11066.9             1          4.44       54835.6
    41           10935.8             1          44.1       32125.6
    42           12364.1             1       1.7e+03       10708.5
    43            9620.6             1          -473       21417.1
    44           8663.82             1          -335       8493.35
    45           8018.15             1          -232       3944.52
    46           7994.14        0.0329          -356       1417.63
    47           7686.47          0.99          2.72       1417.63
    48           7391.23          0.52          -245       1417.63
    49           8438.69         0.625      1.82e+03       1417.63
    50              7147             1         -76.8       2835.27
    51           6995.43         0.394         -12.3       945.089
    52           7095.77         0.485           718       945.089
    53           33530.1             1       1.3e+05       1890.18
    54           51719.4             1      2.63e+05       7560.71
    55           6960.24             1           -14       60485.7
    56           6915.79             1         -18.4       20161.9
    57           6875.11             1           -18       6720.63
    58           6764.66             1         -46.7       2240.21
    59           64622.7         0.647      6.73e+05       746.737
    60           6563.88             1         -44.6       1493.47
    61           6642.37         0.778           116       497.825
    62           6794.83             1           213       995.649
    63           6466.41             1         -5.05        3982.6
    64            6379.5             1          4.56       1327.53
    65           6199.76             1         -72.1       442.511
    66           63537.9        0.0451      8.25e+06       156.317
    67           6210.07             1          29.3       312.634
    68           6352.33         0.902           360       1250.53
    69           6154.35             1         -14.8       10004.3
    70           6134.01         0.889         -8.99       3334.76
    71            6120.9             1         -4.85       3334.76
    72            6240.1             1           173       1111.59
    73           6123.27             1          9.97       2223.17
    74           6115.93             1         0.825       8892.69
    75           6074.49             1         -15.8       2964.23
    76           6097.71             1          64.1       988.076
    77           6056.85             1          29.2       1976.15
    78           6024.52         0.201         -71.8       658.718
    79           6009.57         0.123         -57.3       658.718
    80           5993.13             1          6.91       658.718
    81           6932.28             1      1.81e+03       219.573
    82           5978.03         0.819          -5.7       439.145
    83           5975.85         0.289        -0.847       439.145
    84           5984.92             1          40.6       439.145
    85           6160.52             1           312        878.29
    86           5955.74             1         -6.36       3513.16
    87           5934.82         0.516          10.1       1171.05
    88           5915.66             1          5.28       1171.05
    89           5886.51             1         -4.86        577.28
    90           5881.26           0.2         -7.49       192.427
    91           5880.52         0.287         0.392       192.427
    92           59425.7         0.342      9.05e+05       192.427
    93           59226.1        0.0349      8.67e+06       384.854
    94             14646             1      2.66e+04       1539.41
    95           5877.88             1        -0.854       12315.3
    96            5874.4             1         -1.55        4105.1
    97           5872.85         0.145         -4.84       1368.37
    98            5871.9             1        -0.102       1368.37
    99           5938.07             1           130       456.123
   100           5884.79             1          40.4       912.246
   101           5865.29             1         -2.26       3648.98
   102           5862.37        0.0481         -30.1       1216.33
   103           5816.22             1         -19.7       1216.33
   104           5791.53         0.229         -50.5       405.442
   105           5790.62      0.000692          -647       405.442
   106           5727.67             1         -21.6       405.442
   107           5727.59        0.0234         -0.41       135.147
   108            6151.8         0.334      2.67e+03       135.147
   109           5672.48             1         -17.7       270.295
   110           5671.77        0.0113         -31.2       90.0983
   111           5644.63         0.499         -21.8       90.0983
   112           5616.92             1          -6.1       90.0983
   113            5611.2         0.522         -1.26       30.0328
   114           5606.21        0.0751         -31.7       30.0328
   115            5598.7         0.377           2.8       30.0328
   116           5586.68         0.364          17.8       30.0328
   117           5665.59             1           109       30.0328
   118             49109         0.293      7.13e+05       60.0655
   119           5572.48             1         -2.07       240.262
   120           5574.29             1          6.92       80.0874
   121           5574.18        0.0842          20.9       160.175
   122           5573.23             1          2.53       640.699
   123           6459.87             1           861       5125.59

 Optimization terminated: Constrained optimum found.
 Parameters converged to within tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0       1.06159e+06
     1       1.06158e+06      2.51e-05     -4.03e+04   1.19089e+06
     2       1.06145e+06       0.00164     -4.03e+04   1.19089e+06
     3       1.06144e+06      9.46e-05     -4.03e+04   1.19089e+06
     4       1.06132e+06       0.00154     -4.03e+04   1.19089e+06
     5        1.0613e+06      0.000203     -4.02e+04   1.19089e+06
     6       1.06126e+06      0.000583     -4.02e+04   1.19089e+06
     7       1.06047e+06        0.0098     -4.01e+04   1.19089e+06
     8            995300             1     -2.52e+04   1.19089e+06
     9            952686             1     -1.15e+04        396962
    10            937836             1     -4.69e+03        132321
    11            921834             1     -6.72e+03       44106.9
    12            905619             1     -5.93e+03       14702.3
    13            904480        0.0916     -6.07e+03       4900.77
    14            895875             1     -2.85e+03       4900.77
    15            894961         0.181     -2.41e+03       1633.59
    16            891767             1     -1.02e+03       1633.59
    17            891275         0.221     -1.05e+03        544.53
    18            890560             1          -213        544.53
    19            890386         0.309          -251        181.51
    20            890113             1         -64.6        181.51
    21            890076         0.228           -75       60.5033
    22            889990         0.847         -36.3       60.5033
    23            889959         0.634         -20.2       60.5033
    24            889932             1         -9.83       60.5033
    25            889914             1         -5.37       20.1678
    26            889905          0.74         -5.09       6.72259
    27            889899             1         -2.22       6.72259
    28            889887             1         -6.15       2.24086
    29            889886       0.00148         -32.5      0.746955
    30            889884        0.0442         -32.7      0.746955
    31            889879         0.061         -35.6      0.746955
    32            889803         0.896         -42.7      0.746955
    33            889279             1          -264      0.746955
    34            888935       0.00922     -1.87e+04      0.248985
    35            807283             1     -3.96e+04      0.248985
    36            800042        0.0117     -3.07e+05      0.082995
    37            784266        0.0346     -2.21e+05      0.082995
    38            780949       0.00315     -1.84e+05      0.082995
    39            770014       0.00938     -5.78e+05      0.082995
    40            737530        0.0209        -7e+05      0.082995
    41            310583         0.245     -6.75e+05      0.082995
    42            301722        0.0148     -2.51e+05      0.082995
    43            302206        0.0014       1.6e+06      0.082995
    44            296188       0.00606     -2.36e+05       0.16599
    45            267700        0.0484     -1.53e+05       0.16599
    46            144580         0.228     -2.22e+05       0.16599
    47            129481        0.0616     -9.31e+04       0.16599
    48           74751.7         0.415      5.48e+03       0.16599
    49           94213.4      0.000125      2.94e+09       0.16599
    50           94213.6      0.000122      3.01e+09       0.33198
    51           94214.6      0.000105      3.49e+09       1.32792
    52           94176.7      5.36e-05      6.87e+09       10.6234
    53           93183.5        0.0147      2.57e+07       84.9869
    54             87912         0.104      4.25e+06       679.895
    55           22959.2             1     -6.52e+03       5439.16
    56           12194.4             1          -116       1813.05
    57             36796             1      2.37e+04       604.351
    58           12206.7             1           941        1208.7
    59           95894.2         0.124      1.45e+08       4834.81
    60           83812.3          0.39      3.54e+07       38678.5
    61           11348.3             1          -309        309428
    62             10319             1          -424        103143
    63           9262.58             1          -368       34380.9
    64           9125.57         0.178          -364       11460.3
    65           8567.47             1          -190       11460.3
    66           11118.4             1      2.79e+03       3820.09
    67             77780         0.023      6.09e+09       7640.19
    68           8431.39             1         -64.3       30560.8
    69           8204.76             1         -98.4       10186.9
    70           7532.24             1          -230       3395.64
    71           7470.44         0.254          -118       1131.88
    72           71026.2         0.112      3.32e+09       1131.88
    73           7505.55         0.977          87.6       2263.76
    74           7164.97             1         -19.7       9055.04
    75           69974.7         0.151      9.31e+09       3018.35
    76           7589.13         0.475      1.12e+03       6036.69
    77           6738.14             1          -119       24146.8
    78           6579.94             1         -51.3       8048.92
    79           6456.83           0.5         -80.2       2682.97
    80           6436.27        0.0654          -142       2682.97
    81           6425.22         0.121         -5.79       2682.97
    82           6458.53             1          47.2       2682.97
    83           6420.27         0.118         -17.4       5365.95
    84           6519.93         0.264           741       5365.95
    85           6365.27        0.0928          -138       10731.9
    86           8395.07         0.553      4.16e+03       10731.9
    87           6280.83             1         -8.68       21463.8
    88           16357.8         0.827      1.84e+04        7154.6
    89           6209.18             1         -4.74       14309.2
    90           6786.07         0.668           943       4769.73
    91           6013.64             1         -66.9       9539.47
    92           6634.98         0.536      1.18e+03       3179.82
    93           5801.48             1          85.6       6359.64
    94           5445.62         0.473          -265       2119.88
    95           5287.68             1        -0.126       2119.88
    96           5268.15         0.641          8.45       706.627
    97           5296.42         0.937          40.1       706.627
    98           5226.23             1         -2.63       1413.25
    99           5220.22             1          11.2       471.085
   100           5215.69         0.255          96.4       310.133
   101           5302.77             1           113       310.133
   102           5268.17             1          67.8       620.265
   103           5369.03             1           163       2481.06
   104           5236.62             1            40       19848.5

 Optimization terminated: Constrained optimum found.
 Parameters converged to within tolerance.
Warning: LSQLIN did not converge. Infeasible network contraints.
> In mylsqlin
In multistart
In multistart
In estimate
In inca_script (line 234)

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0       4.68816e+16

 Maximum lambda value exceeded.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0       1.10848e+06
     1       1.10847e+06      1.18e-05     -2.07e+05       2.40522
     2       1.10847e+06      1.38e-05     -2.07e+05       2.40522
     3       1.10846e+06       1.6e-05     -2.07e+05       2.40522
     4       1.10803e+06       0.00104     -2.07e+05       2.40522
     5       1.03703e+06         0.183     -1.73e+05       2.40522
     6       1.00252e+06         0.127     -1.29e+05       2.40522
     7            919668         0.537     -4.78e+04       2.40522
     8            915794        0.0689     -2.61e+04       2.40522
     9            911316        0.0992     -1.99e+04       2.40522
    10            901970         0.325     -9.63e+03       2.40522
    11            901811       0.00669     -1.18e+04       2.40522
    12            895447         0.492     -3.41e+03       2.40522
    13            891880             1          -500       2.40522
    14            887140         0.489     -4.44e+03       2.39512
    15            886116       0.00456     -1.12e+05       2.39512
    16            884613       0.00528     -1.42e+05       2.39512
    17            593303             1     -1.06e+05       2.39512
    18            373899         0.376     -2.26e+05      0.798372
    19            224092             1          -213      0.798372
    20            224019        0.0755          -455      0.266124
    21            223610             1         -46.6      0.266124
    22            223591             1        -0.418     0.0950586
    23            223589        0.0196         -42.1     0.0316862
    24            223582        0.0891         -35.8     0.0316862
    25            223559             1          9.79     0.0316862
    26            223548             1         -2.31     0.0303052
    27            223472             1         -6.97     0.0101017
    28            223579             1           550    0.00336725
    29            223460             1           172     0.0067345
    30            223390             1          -2.1    0.00864196
    31            223389             1        -0.058    0.00288065

 Optimization terminated: Constrained optimum found.
 Parameters converged to within tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0       1.03497e+06
     1       1.03495e+06      9.95e-05     -7.37e+04        545095
     2       1.02543e+06        0.0673     -6.78e+04        545095
     3            960486          0.75     -2.62e+04        545095
     4            955233         0.169     -1.45e+04        545095
     5            937083             1     -5.47e+03        545095
     6            927190             1     -3.94e+03        181698
     7            921287         0.428      -6.4e+03       60566.1
     8            915273         0.568     -4.84e+03       60566.1
     9            914506         0.135     -2.82e+03       60566.1
    10            914369         0.025     -2.75e+03       60566.1
    11            909382             1     -2.25e+03       60566.1
    12            906412         0.322     -4.36e+03       20188.7
    13            900123             1      -2.5e+03       20188.7
    14            900038        0.0117     -3.63e+03       6729.57
    15            897062         0.473     -2.68e+03       6729.57
    16            893886             1     -1.06e+03       6729.57
    17            891877             1          -747       2243.19
    18            890938         0.476          -878        747.73
    19            890425             1          -158        747.73
    20            890064             1         -82.5       249.243
    21            889943             1         -28.3       83.0811
    22            889932         0.294         -16.1       27.6937
    23            889922         0.467         -8.07       27.6937
    24            889917         0.525         -4.19       27.6937
    25            889911             1         -2.15       27.6937
    26            889900             1         -5.45       9.23124
    27            889895         0.102         -22.8       3.07708
    28            889846             1         -24.7       3.07708
    29            889603         0.578          -212       1.02569
    30            889588       0.00419     -1.78e+03       1.02569
    31            889512        0.0199     -1.93e+03       1.02569
    32            888224         0.234     -2.76e+03       1.02569
    33            825212         0.866     -3.05e+04       1.02569
    34            809387       0.00328     -2.19e+06       1.02569
    35            804503       0.00128      -1.9e+06       1.02569
    36            775697        0.0313     -4.54e+05       1.02569
    37            767018        0.0118     -3.61e+05       1.02569
    38            753203        0.0134     -5.12e+05       1.02569
    39            752882       0.00482     -3.37e+04       1.02569
    40            729170        0.0238     -4.88e+05       1.02569
    41           23795.7         0.945      5.25e+04       1.02569
    42           13742.3         0.592     -2.46e+03       1.02569
    43             13867         0.153      5.22e+03       1.02569
    44           23844.8        0.0747      6.95e+05       2.05139
    45           23900.7        0.0431      1.19e+06       8.20554
    46           23694.3       0.00344      1.71e+07       65.6443
    47           10482.3             1           419       525.155
    48           21335.9         0.152      2.33e+06       175.052
    49           25971.6        0.0676       5.1e+06       350.103
    50           22524.1         0.407      9.23e+04       1400.41
    51           7816.04             1          -914       11203.3
    52           19632.8        0.0515      3.51e+06       3734.43
    53           7139.72             1          -122       7468.87
    54           5163.51             1          95.8       2489.62
    55           5020.44         0.132          -517       829.874
    56           4172.77             1          -133       829.874
    57           4230.24             1           867       276.625
    58           15621.5             1      4.23e+04       553.249
    59           11631.1             1      2.16e+04          2213
    60           4107.81             1         -20.8         17704
    61           4065.64             1         -12.4       5901.33
    62           3901.64             1         -63.4       1967.11
    63           3977.77        0.0632      1.46e+03       655.703
    64           3875.65         0.111          -114       1311.41
    65            4040.2             1           315       1311.41
    66           3870.58         0.012          -140       2622.81
    67           3762.43             1         -45.6       2622.81
    68           3715.37         0.332         -67.2       874.271
    69           3710.83         0.103         -15.4       874.271
    70           3591.89             1         -49.5       874.271
    71           18469.2         0.929      5.28e+04       291.424
    72           3541.58             1          17.3       582.847
    73           3195.68             1         -14.4       194.282
    74           3057.14             1           137       99.8734
    75           2917.31             1          18.2       99.6069
    76           3339.99             1      1.22e+03        62.128
    77           2789.89             1         -8.88       124.256
    78           2788.51        0.0228         -17.3       41.4187
    79           2762.89             1          15.5       41.4187
    80           2762.32             1          23.5       40.8554
    81           2727.93             1         0.707       68.7158
    82           2723.55         0.786          12.3       43.0003
    83           2710.12             1         -1.81       43.0003
    84           2699.53             1         -2.98       22.4768
    85            2700.1             1          9.49       7.49226
    86           2700.39        0.0136          75.4       14.9845
    87            2695.2             1         -1.61       59.9381
    88           3947.25             1       2.7e+03       19.9794
    89            2719.9             1          53.1       39.9587
    90           2789.27             1           160       159.835
    91           2717.33          0.65          35.2       1278.68
    92           2692.75             1         -1.01       10229.4
    93           2687.93             1         -2.17       3409.81
    94           2687.15       0.00409         -93.8        1136.6
    95           2725.84         0.148           470        1136.6
    96           2688.21         0.375          18.4       2273.21
    97           3330.32             1      1.01e+03       9092.83

 Optimization terminated: Constrained optimum found.
 Parameters converged to within tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0            920519
     1            920480      0.000641     -3.11e+04       4.18542
     2            911316         0.148     -3.32e+04       4.18542
     3            909710        0.0367     -2.15e+04       4.18542
     4            900927         0.238     -1.62e+04       4.18542
     5            890268             1      1.06e+03       4.18542
     6            890147         0.201          -252       1.39514
     7            889927             1           -39       1.39514
     8            889849             1           -33       0.80123
     9            889813        0.0412          -441      0.308613
    10            889632         0.115          -793      0.308613
    11            881474             1     -4.05e+03      0.308613
    12            852172        0.0289        -5e+05      0.102871
    13            234346             1     -2.15e+04      0.102871
    14           36304.9             1     -5.32e+04     0.0342904
    15           1090.73             1          3.98     0.0114301
    16           1083.98             1         -1.49    0.00381004
    17           1073.59             1        -0.756    0.00388618
    18           1073.46             1      -0.00645    0.00129539
    19           1073.46             1     -5.11e-05    0.00059209
    20           1063.51             1           110   0.000234243
    21           1007.23             1         -3.37   0.000318101
    22           1028.54       0.00875      9.98e+05   0.000106034
    23           1028.51        0.0163      5.34e+05   0.000212068
    24           1028.34        0.0619      1.41e+05    0.00084827
    25           1026.83         0.487      1.74e+04    0.00678616
    26           1006.87             1       -0.0134     0.0542893
    27           1025.02          0.96      6.35e+03     0.0180964
    28           1005.36         0.623        -0.681     0.0361929
    29           1005.26             1        -0.113     0.0361929
    30           1021.61         0.194       7.1e+03     0.0120643
    31           1021.56         0.382       3.6e+03     0.0241286
    32           1005.02             1        -0.321     0.0965143
    33           1019.57         0.198      2.22e+03     0.0321714
    34           1019.43         0.378      1.16e+03     0.0643429
    35           1004.39             1        -0.734      0.257371
    36           1014.41         0.236           493     0.0857905
    37           1014.04         0.423           270      0.171581
    38           1003.22             1        -0.866      0.686324
    39           1006.34         0.386          63.5      0.228775
    40           1005.65         0.674          33.9      0.457549
    41           1002.11             1        -0.639        1.8302
    42           1001.59         0.813          8.16      0.610066
    43           998.404             1       -0.0507      0.610066
    44           998.378             1       0.00251      0.203355
    45           998.376             1      0.000337      0.122267
    46           998.376             1      2.07e-05     0.0955271
    47           998.376             1     -2.86e-05     0.0829372
    48           998.376             1     -8.66e-05     0.0324357
    49           998.375             1     -0.000241     0.0108119
    50           998.374             1     -0.000564    0.00360396

 Optimization terminated: Constrained optimum found.
 Norm of gradient less than tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0       1.16209e+06
     1       1.16208e+06      2.51e-05     -2.36e+05       1.70106
     2       1.16207e+06      2.14e-05     -2.36e+05       1.70106
     3       1.16205e+06      3.35e-05     -2.36e+05       1.70106
     4       1.16194e+06      0.000231     -2.36e+05       1.70106
     5            945177         0.451     -1.88e+05       1.70106
     6            925810         0.221     -3.55e+04       1.70106
     7            905404         0.722      7.47e+03       1.70106
     8            904060        0.0501     -1.26e+04       1.70106
     9            896488         0.456     -5.23e+03       1.70106
    10            891623             1          -790       1.70106
    11            891588        0.0186          -918       1.04978
    12            890958             1         -89.3       1.04978
    13            890930        0.0292          -442       1.02612
    14            890677         0.408          -232       1.02612
    15            890675       0.00107     -1.21e+03       1.02612
    16            890367         0.146          -995       1.02612
    17            882495             1     -3.91e+03       1.02612
    18            457763             1     -4.97e+04       0.34204
    19            447275             1          -274      0.114013
    20            447048             1         -91.4     0.0380044
    21            446122             1         -8.94     0.0126681
    22            445986             1         -2.17    0.00630133
    23            445980             1        -0.356    0.00210044
    24            445980             1        0.0568   0.000700148
    25            445980             1          0.04   0.000302356
    26            445980         0.451       -0.0124   0.000286406
    27            445980             1       0.00102   0.000286406
    28            445980             1      0.000438   0.000231859
    29            445980         0.886      0.000102    0.00023145
    30            445980             1      2.31e-05    0.00023145

 Optimization terminated: Constrained optimum found.
 Norm of gradient less than tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0            916022
     1            915984      0.000696     -2.71e+04       2.84282
     2            915845       0.00256      -2.7e+04       2.84282
     3            915834      0.000204      -2.7e+04       2.84282
     4            915653       0.00337     -2.68e+04       2.84282
     5            915622      0.000582     -2.68e+04       2.84282
     6            915397       0.00422     -2.66e+04       2.84282
     7            914166        0.0235     -2.58e+04       2.84282
     8            914128       0.00075     -2.53e+04       2.84282
     9            911161         0.061     -2.34e+04       2.84282
    10            910204        0.0218     -2.17e+04       2.84282
    11            906832        0.0833     -1.92e+04       2.84282
    12            898593         0.273     -1.24e+04       2.84282
    13            898481       0.00574     -9.74e+03       2.84282
    14            897791        0.0364     -9.24e+03       2.84282
    15            890314         0.972          32.1       2.84282
    16            889654             1          -199       2.84282
    17            889509        0.0481     -1.47e+03       2.51217
    18            885104             1     -2.17e+03       2.51217
    19            799515         0.195      -2.1e+05      0.837389
    20            625848         0.133     -6.09e+05      0.837389
    21           2493.58             1     -2.29e+03      0.837389
    22           1083.53             1             8       0.27913
    23           1004.01             1            -7     0.0930432
    24           998.544             1        -0.316     0.0310144
    25           998.397             1      -0.00329     0.0103381

 Optimization terminated: Constrained optimum found.
 Parameters converged to within tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0       1.03765e+06
     1       1.03765e+06      2.24e-05     -5.01e+04        345116
     2        1.0376e+06      0.000482     -5.01e+04        345116
     3       1.00021e+06         0.447     -3.45e+04        345116
     4            991493          0.17     -2.42e+04        345116
     5            979356         0.299     -1.84e+04        345116
     6            955589             1     -8.14e+03        345116
     7            955410       0.00802     -1.11e+04        115039
     8            948715         0.324     -9.62e+03        115039
     9            940471         0.542     -6.88e+03        115039
    10            938435          0.18     -5.53e+03        115039
    11            933988         0.442      -4.8e+03        115039
    12            926051             1     -3.65e+03        115039
    13            912960             1     -5.68e+03       38346.2
    14            899291             1     -4.98e+03       12782.1
    15            899267       0.00245     -4.85e+03       4260.69
    16            892530             1     -1.85e+03       4260.69
    17            890524             1          -596       1420.23
    18            890297         0.161          -676        473.41
    19            890109             1         -52.3        473.41
    20            890014             1         -32.8       157.803
    21            889952             1         -21.1       52.6011
    22            889932         0.566         -13.9       17.5337
    23            889918             1         -4.13       17.5337
    24            889909             1          -3.6       5.84457
    25            889907         0.106          -6.4       2.75087
    26            889897             1         -4.24       2.75087
    27            889893         0.123           -19       1.28205
    28            889859         0.966           -15       1.28205
    29            889772             1           -43       1.28205
    30            889653        0.0951          -627      0.427351
    31            885905             1     -1.87e+03      0.427351
    32            880534       0.00245      -1.1e+06       0.14245
    33            879709       0.00131     -3.16e+05       0.14245
    34            833780        0.0124     -1.81e+06       0.14245
    35            827776         0.011     -2.67e+05       0.14245
    36            790401        0.0245      -7.5e+05       0.14245
    37            788457       0.00124      -7.4e+05       0.14245
    38            772766        0.0164     -1.84e+05       0.14245
    39            726869        0.0642     -3.39e+05       0.14245
    40            717984        0.0243      -1.8e+05       0.14245
    41            693740        0.0376     -3.15e+05       0.14245
    42            688686        0.0271     -8.69e+04       0.14245
    43            665410        0.0357     -3.15e+05       0.14245
    44            631146        0.0268     -5.97e+05       0.14245
    45            454988          0.22     -3.31e+05       0.14245
    46            334040             1      4.59e+04       0.14245
    47            309767        0.0751     -1.24e+05      0.113158
    48            300369        0.0742     -5.17e+04      0.113158
    49            266500         0.614      3.06e+04      0.113158
    50            287593         0.522      6.04e+04      0.113158
    51            287593         0.522      6.04e+04      0.226316
    52            287593         0.522      6.04e+04      0.905263
    53            287593         0.521      6.05e+04        7.2421
    54            287595         0.513      6.17e+04       57.9368
    55            298034          0.53      8.28e+04       463.495
    56            358257         0.198      5.66e+05       3707.96
    57            252138             1     -3.63e+03       29663.7
    58            253455             1      2.79e+03       9887.89
    59            246314             1          -659       19775.8
    60            241978             1          -685       7467.08
    61            239187             1     -1.11e+03       2522.15
    62            239044         0.037      -1.9e+03       997.917
    63            235884             1     -1.14e+03       997.917
    64            233606             1          -727       465.988
    65            233036          0.28          -889       184.462
    66            232588         0.155      -1.1e+03       184.462
    67            231704             1          -253       184.462
    68            231704         0.144          90.2       74.6033
    69            231576         0.122          -487       74.6033
    70            231076             1         -62.4       74.6033
    71            229779             1          -357       60.0483
    72            270817           0.8      2.47e+05       39.6206
    73            230840             1      2.02e+03       79.2412
    74            231973             1      4.04e+03       316.965
    75            231102             1      2.35e+03       2535.72
    76            229585             1         -77.6       20285.8
    77            229404             1         -73.7       6761.92
    78            229234             1         -53.8       2253.97
    79            229014             1           198       751.324
    80            228995             1           508       250.441
    81            228994             1           240         377.7
    82            228515             1          -155       750.055
    83            228829             1           634       401.246
    84            228556         0.292           319       802.491
    85            228438             1         -30.7       3209.96
    86            229447             1      1.44e+03       1069.99
    87            228429             1           111       2139.98
    88            228589             1           302       3578.51
    89            228355             1         -17.7       7157.02
    90            228292        0.0802          -384       3670.88
    91            228160        0.0592          -635       3670.88
    92            227431             1          -231       3670.88
    93            227471         0.121           434       2137.64
    94            227210             1         -16.2       4275.27
    95            227130         0.883          10.5       3345.53
    96            227139         0.572          22.8       3345.53
    97            227119             1          6.48       6691.06
    98            227152             1          38.6       5648.05
    99            227129             1          15.9       11296.1
   100            227143             1          57.9       45184.4

 Optimization terminated: Constrained optimum found.
 Parameters converged to within tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0            926165
     1            925099        0.0148     -3.57e+04        31.334
     2            922847        0.0326     -3.38e+04        31.334
     3            922778       0.00104     -3.31e+04        31.334
     4            920265         0.039     -3.14e+04        31.334
     5            919617        0.0107     -3.02e+04        31.334
     6            900336         0.423     -1.63e+04        31.334
     7            896212         0.237     -7.36e+03        31.334
     8            894380         0.165     -4.99e+03        31.334
     9            894275        0.0122     -4.26e+03        31.334
    10            891494         0.423     -2.39e+03        31.334
    11            890656         0.332     -1.01e+03        31.334
    12            890001         0.697          -238        31.334
    13            889990        0.0631         -83.2        31.334
    14            889900             1         -11.3        31.334
    15            889875             1         -8.51       10.4447
    16            889855             1         -6.57       3.48155
    17            889809             1         -16.5       1.63806
    18            889777         0.133          -121      0.659207
    19            889719         0.125          -233      0.659207
    20            888719         0.929          -538      0.659207
    21            885322        0.0696     -2.44e+04      0.659207
    22            480849             1     -1.58e+05      0.659207
    23           1047.45             1          -303      0.219736
    24           998.438             1       -0.0161     0.0732452
    25           998.397             1      0.000222     0.0244151

 Optimization terminated: Constrained optimum found.
 Parameters converged to within tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0            949007
     1            948957      0.000432     -5.82e+04       1.91754
     2            948928      0.000243     -5.82e+04       1.91754
     3            948926      2.42e-05     -5.82e+04       1.91754
     4            948919      5.48e-05     -5.82e+04       1.91754
     5            948899      0.000172     -5.81e+04       1.91754
     6            948885      0.000126     -5.81e+04       1.91754
     7            948811      0.000632      -5.8e+04       1.91754
     8            948323       0.00423     -5.73e+04       1.91754
     9            941910        0.0606     -4.86e+04       1.91754
    10            938022        0.0395     -4.68e+04       1.91754
    11            934407        0.0393      -4.4e+04       1.91754
    12            919219         0.223     -2.59e+04       1.91754
    13            918220        0.0171     -2.84e+04       1.91754
    14            908800         0.224     -1.53e+04       1.91754
    15            898041             1           280       1.91754
    16            896822        0.0752     -6.02e+03       1.91424
    17            879201             1     -8.25e+03       1.91424
    18            848100        0.0363     -4.21e+05       1.69159
    19            835073       0.00973     -6.65e+05       1.69159
    20           38497.3             1     -6.64e+04       1.69159
    21           1467.71             1          -676      0.563865
    22           1103.84             1          10.5      0.187955
    23           1089.32             1          1.95     0.0853889
    24           1073.59             1          -3.4      0.085727
    25           1070.98             1        -0.383       0.06322
    26           1070.84             1       -0.0274      0.029874
    27           1070.82             1      -0.00533     0.0294061
    28           1070.81             1      -0.00241     0.0263506
    29            1070.8             1      -0.00147     0.0245723
    30            1070.8         0.979      -0.00104      0.021241
    31            1070.8             1     -0.000698      0.021241

 Optimization terminated: Constrained optimum found.
 Norm of gradient less than tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0       1.06115e+06
     1       1.06114e+06      3.38e-05     -1.66e+05       1.16063
     2       1.06114e+06      2.07e-05     -1.66e+05       1.16063
     3       1.06109e+06       0.00013     -1.66e+05       1.16063
     4       1.05511e+06        0.0189     -1.51e+05       1.16063
     5       1.05347e+06       0.00521     -1.55e+05       1.16063
     6       1.04673e+06         0.023     -1.36e+05       1.16063
     7       1.04672e+06      2.28e-05     -1.52e+05       1.16063
     8       1.04574e+06       0.00326     -1.49e+05       1.16063
     9       1.04026e+06        0.0191     -1.36e+05       1.16063
    10       1.02633e+06        0.0557     -1.07e+05       1.16063
    11       1.01969e+06        0.0274     -1.11e+05       1.16063
    12       1.01144e+06         0.037     -9.79e+04       1.16063
    13            977559         0.322      -2.4e+04       1.16063
    14            965772         0.142     -2.06e+04       1.16063
    15            962108        0.0318        -4e+04       1.16063
    16            889618             1     -3.03e+04       1.16063
    17            847419        0.0395     -5.07e+05       1.16062
    18            557527         0.262     -4.71e+05       1.16062
    19            169602         0.515     -2.41e+05       1.16062
    20            9285.5             1     -7.01e+03       1.16062
    21           2160.27         0.827          -959      0.386873
    22           1906.81         0.228          -471      0.386873
    23           1685.54         0.355          -240      0.386873
    24            1528.1             1         -6.15      0.386873
    25           1526.69             1         -0.12      0.128958
    26           1524.74             1        -0.952     0.0429858
    27           1453.87         0.907         -31.4     0.0143286
    28           1353.65         0.638          6.95     0.0143286
    29           1299.13             1          1.81     0.0143286
    30           1273.06             1          45.4     0.0133946
    31           1259.63             1         -1.88      0.013101
    32           1258.88             1       -0.0529    0.00436701
    33           1258.85             1       -0.0101    0.00145567
    34           1258.69             1       -0.0578   0.000485223
    35           1258.62             1       0.00133   0.000161741
    36           1258.62             1      0.000132   5.39137e-05
    37              1258        0.0117           -26    2.0326e-05
    38           1234.77             1          8.62    2.0326e-05
    39           1997.39         0.792      3.35e+03   9.73639e-06
    40           1835.15             1      1.99e+03   1.94728e-05
    41           1229.51             1          11.6   7.78911e-05
    42           1996.22          0.48      3.62e+03    7.8053e-05
    43           1996.22          0.48      3.62e+03   0.000156106
    44           1996.23         0.481      3.62e+03   0.000624424
    45           1996.29         0.484       3.6e+03    0.00499539
    46           1996.82         0.509      3.42e+03     0.0399631
    47           2001.13          0.71      2.47e+03      0.319705
    48           1250.33             1          46.3       2.55764
    49           1221.44             1         -1.39       20.4611
    50           1220.25             1           1.3       6.82038
    51           1218.12             1        -0.304       6.87629
    52           1216.86             1        -0.345        6.4993
    53           1216.18             1        -0.195       5.20669
    54            1215.7             1        -0.163       4.51314
    55           1215.35             1        -0.116       3.52941
    56           1215.09             1       -0.0918       2.88282
    57           1214.89             1       -0.0704       2.28469
    58           1214.73             1        -0.056       1.83784
    59           1214.61             1        -0.045         1.466
    60           1214.51             1       -0.0366       1.16803
    61           1214.44             1       -0.0299      0.926905
    62           1214.37             1       -0.0244      0.734227
    63           1214.32             1         -0.02      0.581011
    64           1214.28             1       -0.0163      0.459667
    65           1214.28      1.03e-05       -0.0218      0.363727
    66           1214.24             1       -0.0133      0.363727
    67           1214.22             1       -0.0107       0.28792
    68           1214.19             1      -0.00869      0.228018
    69           1214.18             1      -0.00701      0.180665
    70           1214.16             1      -0.00564      0.143212
    71           1214.15             1      -0.00453      0.113572
    72           1214.14             1      -0.00363     0.0901013
    73           1214.13             1      -0.00291     0.0715046
    74           1214.13             1      -0.00232     0.0567624
    75           1214.12             1      -0.00185     0.0450706
    76           1214.12             1      -0.00148     0.0357942
    77           1214.12             1      -0.00118     0.0284319
    78           1214.11             1      -0.00094      0.022587
    79           1214.11             1     -0.000748     0.0179456
    80           1214.11             1     -0.000596     0.0142593
    81           1214.11             1     -0.000381     0.0113311

 Optimization terminated: Constrained optimum found.
 Norm of gradient less than tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0            969272
     1            969248      0.000153     -7.87e+04       7.14338
     2            969244      2.47e-05     -7.87e+04       7.14338
     3            969230      8.66e-05     -7.87e+04       7.14338
     4            969218      7.89e-05     -7.87e+04       7.14338
     5            969208      6.39e-05     -7.87e+04       7.14338
     6            969177      0.000193     -7.86e+04       7.14338
     7            969081      0.000612     -7.86e+04       7.14338
     8            907907         0.591     -2.98e+04       7.14338
     9            906884        0.0293      -1.7e+04       7.14338
    10            906732       0.00453     -1.67e+04       7.14338
    11            904481        0.0712      -1.5e+04       7.14338
    12            890918         0.917     -2.25e+03       7.14338
    13            889906             1          -173       7.14338
    14            889775         0.464          -111       3.80454
    15            889405             1          -176       3.80454
    16            882635             1     -3.37e+03       1.26818
    17            882067       0.00064     -4.43e+05      0.422727
    18            874000       0.00878     -4.58e+05      0.422727
    19            242598             1     -5.81e+04      0.422727
    20            202653        0.0871     -2.19e+05      0.140909
    21           1414.81             1          -573      0.140909
    22           1414.72      0.000145          -299     0.0469697
    23           1343.65             1           460     0.0469697
    24           1125.46             1         -21.6     0.0537875
    25           1242.86         0.264      1.88e+03     0.0179292
    26           1241.84         0.267      1.85e+03     0.0358583
    27           1235.94          0.29      1.69e+03      0.143433
    28           1191.64         0.486           939       1.14747
    29           1098.56         0.966           356       9.17973
    30           1050.16             1         -2.35       9.17973
    31           1048.14         0.442         -1.61       3.05991
    32           1046.03             1        -0.464       3.05991
    33           1045.12             1        -0.274       1.68912
    34           1044.52         0.401        -0.739      0.563042
    35           1041.63             1         -1.41      0.563042
    36           1015.53             1         -9.49      0.187681
    37           1013.25        0.0721         -15.1     0.0625602
    38           1012.07         0.042         -13.6     0.0625602
    39           999.103             1        -0.962     0.0625602
    40           998.924             1      0.000607     0.0208534

 Optimization terminated: Constrained optimum found.
 Parameters converged to within tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0            922440
     1            922438      1.75e-05     -3.31e+04      0.953349
     2            922405      0.000502     -3.31e+04      0.953349
     3            916979        0.0873     -2.91e+04      0.953349
     4            915100         0.035     -2.61e+04      0.953349
     5            909329         0.124      -2.1e+04      0.953349
     6            902828         0.187      -1.5e+04      0.953349
     7            899249          0.16     -9.87e+03      0.953349
     8            891835         0.719     -2.31e+03      0.953349
     9            891524         0.107     -1.24e+03      0.953349
    10            891030         0.237          -774      0.953349
    11            890443         0.378          -586      0.953349
    12            886189             1     -2.05e+03      0.953349
    13            510520             1     -1.03e+05      0.328485
    14            472089         0.202     -8.76e+04      0.109495
    15            456511        0.0319      -2.4e+05      0.109495
    16            343919         0.282     -1.67e+05      0.109495
    17            333275        0.0453     -1.15e+05      0.109495
    18            301820         0.156     -9.24e+04      0.109495
    19            223575             1          -112      0.109495
    20            223571         0.213      9.93e+03     0.0364984
    21            223302             1          17.8     0.0364984
    22            223301             1          15.4     0.0121661
    23            223292             1          -1.4     0.0228333
    24            223292             1      -0.00498     0.0076111
    25            223292             1       -0.0188    0.00763234
    26            223267             1          2.16    0.00254411
    27            223265             1        0.0134    0.00137516
    28            223888         0.329      4.07e+06   0.000458387
    29            223250          0.33         -17.8   0.000916774
    30            223770         0.162      4.06e+06   0.000916774
    31            223728         0.324      1.89e+06    0.00183355
    32            223237             1         0.579     0.0073342
    33            223597         0.139      7.62e+05    0.00297277
    34            223592         0.277       3.8e+05    0.00594554
    35            223235             1          1.46     0.0237821
    36            223559        0.0493      1.89e+05    0.00792738
    37            223559        0.0858      1.09e+05     0.0158548
    38            223557         0.305      3.06e+04     0.0634191
    39            223235             1        -0.259      0.507352
    40            223541         0.453      1.19e+04      0.169117
    41            223540         0.884      6.11e+03      0.338235
    42            223234             1        -0.191       1.35294
    43            223524         0.851      4.49e+03       0.45098
    44            223234             1          2.66       0.90196
    45            223242         0.791          37.9       1.46242
    46            223233             1         0.194       2.92485
    47            223232         0.114         -2.03       2.22114
    48            223349             1           450       2.22114
    49            223232             1          4.75       4.44228
    50            223227             1        -0.774       6.27526
    51            223224             1         0.796       4.42955
    52            223221             1        -0.613       4.34484
    53            223221             1       -0.0486       1.44828
    54            223221             1      -0.00916      0.920643
    55            223221             1     -0.000417      0.306881
    56            223221             1     -0.000196      0.102294
    57            223221             1     -0.000789     0.0340979
    58            195739        0.0639     -2.08e+05      0.011366
    59           1480.27          0.95     -9.69e+03      0.011366
    60           998.376             1     -0.000205      0.011366
    61           998.375         0.126      -0.00419    0.00378866
    62           998.374         0.197      -0.00107    0.00378866
    63           998.373             1     -0.000313    0.00378866

 Optimization terminated: Constrained optimum found.
 Norm of gradient less than tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0            965600
     1            965598      1.26e-05      -7.5e+04        7.2448
     2            965596      1.01e-05      -7.5e+04        7.2448
     3            965595      1.04e-05      -7.5e+04        7.2448
     4            965593      1.08e-05      -7.5e+04        7.2448
     5            955964        0.0647     -7.38e+04        7.2448
     6            933827         0.174     -6.08e+04        7.2448
     7            902520             1      4.82e+04        7.2448
     8            890828             1      -1.8e+03       6.62805
     9            890460         0.236          -598       2.47524
    10            890037         0.525          -244       2.47524
    11            889839         0.236          -355       2.47524
    12            889570         0.188          -675       2.47524
    13            889268        0.0797     -1.88e+03       2.47524
    14            880934             1     -4.11e+03       2.47524
    15            728723         0.194     -3.64e+05      0.825081
    16            711565         0.013     -6.37e+05      0.825081
    17           13412.7         0.967     -4.67e+04      0.825081
    18           1473.08             1         -88.6      0.825081
    19           1451.93             1        -0.528      0.275027
    20           1448.24             1        -0.627      0.210782
    21           1447.44             1        -0.149      0.158886
    22           1447.27             1        -0.057     0.0874818
    23           1447.02             1        -0.122     0.0371474
    24           1446.69          0.11         -1.47     0.0123825
    25           1442.96         0.454         -4.07     0.0123825
    26           1369.05             1         -19.6     0.0123825
    27           1331.63             1          7.35    0.00412749
    28           1317.18             1         0.251    0.00290282
    29           1316.38         0.717        -0.254   0.000967607
    30            1316.3             1      -0.00252   0.000967607

 Optimization terminated: Constrained optimum found.
 Parameters converged to within tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0            974122
     1            974104      0.000108     -8.23e+04       1.27317
     2            974101       1.6e-05     -8.23e+04       1.27317
     3            974099      1.31e-05     -8.23e+04       1.27317
     4            974078      0.000132     -8.22e+04       1.27317
     5            974055      0.000139     -8.22e+04       1.27317
     6            973664       0.00239      -8.1e+04       1.27317
     7            973570      0.000574     -8.16e+04       1.27317
     8            971699        0.0119     -7.59e+04       1.27317
     9            963002        0.0661     -5.41e+04       1.27317
    10            962971      0.000215     -7.17e+04       1.27317
    11            953266        0.0828     -4.77e+04       1.27317
    12            936298         0.169     -4.06e+04       1.27317
    13            927883         0.106      -3.4e+04       1.27317
    14            915536         0.222     -2.05e+04       1.27317
    15            901410         0.957          -659       1.27317
    16            900045        0.0849     -5.41e+03       1.27317
    17            895138         0.468     -3.91e+03       1.27317
    18            892041        0.0111     -1.37e+05       1.27317
    19            494772             1     -1.35e+05       1.27317
    20            268392         0.273     -3.47e+05      0.424389
    21           4298.57             1     -1.69e+03      0.424389
    22           2055.94             1          -199      0.141463
    23           2009.73         0.138          -158     0.0494745
    24           1938.59         0.175          -191     0.0494745
    25           1911.41        0.0349          -383     0.0494745
    26           1484.66             1         -6.11     0.0494745
    27           1347.21             1         -11.8     0.0164915
    28           1339.66             1         -1.29    0.00549716
    29              1330         0.794          1.56    0.00183239
    30           1328.16             1        -0.149    0.00183239
    31           1328.13             1      -0.00251   0.000610796

 Optimization terminated: Constrained optimum found.
 Parameters converged to within tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0            929613
     1            929613      3.13e-05     -3.55e+03        194780
     2            929611      0.000156     -3.55e+03        194780
     3            924173             1     -1.88e+03        194780
     4            915910             1     -3.73e+03       64926.6
     5            904273             1     -4.61e+03       21642.2
     6            895602             1     -2.74e+03       7214.07
     7            892192             1        -1e+03       2404.69
     8            890955         0.654          -782       801.563
     9            890607             1          -124       801.563
    10            890267             1          -134       267.188
    11            890187         0.258          -147       89.0626
    12            889992             1         -64.3       89.0626
    13            889926             1         -13.8       29.6875
    14            889913             1         -2.91       9.89585
    15            889894             1         -9.05       3.29862
    16            889867         0.443         -29.6       1.09954
    17            889826         0.412           -50       1.09954
    18            889825       0.00339          -129       1.09954
    19            889790         0.137          -129       1.09954
    20            889679         0.239          -235       1.09954
    21            888101             1          -792       1.09954
    22            708023             1     -8.29e+04      0.366513
    23            658992        0.0385     -6.05e+05      0.122171
    24            658631       1.4e-05     -1.31e+07      0.122171
    25            655556       0.00487     -3.01e+05      0.122171
    26            634780        0.0101     -8.83e+05      0.122171
    27            626882        0.0126     -3.08e+05      0.122171
    28            621233       0.00861     -3.09e+05      0.122171
    29            573181         0.047     -4.97e+05      0.122171
    30            555298        0.0202     -4.38e+05      0.122171
    31            372389        0.0326      -2.4e+06      0.122171
    32            356492        0.0238     -3.17e+05      0.122171
    33           14378.9             1     -9.07e+03      0.122171
    34           7996.28             1           634     0.0407236
    35           8874.91             1      1.23e+04     0.0172154
    36           9142.69             1      1.52e+04     0.0344308
    37           13686.3             1      8.16e+04      0.137723
    38           29514.1             1      -3.5e+05       1.10178
    39           7685.17         0.672      2.31e+03       8.81427
    40           7442.66             1          22.5       8.81427
    41           7363.43             1         -15.9       2.93809
    42           7332.93             1         -9.66      0.979364
    43           7938.33             1           849      0.383638
    44           7361.93             1            78      0.767276
    45           7312.39             1          5.21        3.0691
    46           7307.42             1          1.81       1.02303
    47           7292.08             1         -7.41      0.532304
    48           7293.68        0.0799          90.3      0.177435
    49           7113.98             1         -54.4      0.354869
    50           6925.39         0.349           138       0.11829
    51           6957.58             1          73.3       0.11829
    52            6470.7             1         -79.2      0.236579
    53           7949.39         0.929      2.47e+03     0.0788598
    54           7952.01         0.929      2.47e+03       0.15772
    55           7967.92         0.931       2.5e+03      0.630879
    56           8121.24         0.942      2.72e+03       5.04703
    57           9163.64         0.983      4.34e+03       40.3762
    58             10010         0.935      5.44e+03        323.01
    59           21645.9         0.478      1.23e+05       2584.08
    60           6398.23             1         -21.5       20672.6
    61           7014.75             1      1.04e+03       6890.88
    62           6339.31             1         -14.5       13781.8
    63            6504.1         0.589           327       4593.92
    64           6145.98             1          83.2       9187.84
    65           6008.79             1         -25.8       3062.61
    66           5316.04         0.902          -257       1020.87
    67           5275.07        0.0227          -821       1020.87
    68           4906.01         0.849         -90.7       1020.87
    69           4528.89             1          -135       1020.87
    70           5154.62         0.357      1.37e+03        340.29
    71           6536.21         0.622      2.55e+03        680.58
    72           4571.21             1           112       2722.32
    73           4500.03             1         -11.3       21778.6
    74           4750.81             1           421       7259.52
    75           4462.26             1         -17.7         14519
    76           4906.65             1           533       4839.68
    77            4413.7             1         -22.5       9679.37
    78           4407.25        0.0419           -76       3226.46
    79           4404.55        0.0575           -23       3226.46
    80            4390.7         0.196         -34.6       3226.46
    81           4600.55             1           289       3226.46
    82           4356.12             1         -5.44       6452.91
    83           4203.04             1         -61.4       2150.97
    84            3951.6             1          -104        716.99
    85           3950.42         0.002          90.8       238.997
    86           3638.89             1          -103       238.997
    87           3478.75             1           -42       118.232
    88           5733.72             1      4.35e+03       77.3149
    89           9198.29         0.478      2.87e+04        154.63
    90           3457.42         0.362         -23.5       618.519
    91           3513.17             1          60.2       618.519
    92           3430.71             1         -10.9       1237.04
    93           3418.63             1          6.35       412.346
    94           3402.61             1          44.8       189.813
    95           3388.82         0.822            12       188.511
    96           3630.98             1           501       188.511
    97           3450.55             1           101       377.022
    98           3420.13             1          44.7       1508.09
    99           3385.18             1          3.55       12064.7
   100           3379.79             1         -1.19       4021.56
   101           3383.87             1          3.94       1340.52
   102           3374.81             1         -2.26       2681.04
   103           3637.11         0.683           472       893.681
   104           3370.93        0.0303         -7.44       1787.36
   105           3366.09             1         -1.67       1787.36
   106           3356.01             1         -0.16       595.787
   107           3370.61             1          15.7       198.596
   108           3350.82         0.437          2.35       397.191
   109            3371.8             1          24.5       397.191
   110           3359.66             1          9.82       794.383
   111           3305.56         0.681         -28.5       3177.53
   112           3268.33             1         -14.7       3177.53
   113           3425.35         0.447           542       1059.18
   114            3274.9         0.607          62.3       2118.35
   115           3238.73             1         -12.3       8473.42
   116           3237.65        0.0268           -20       2824.47
   117           3229.23         0.199         -13.4       2824.47
   118           3205.24         0.491         -20.9       2824.47
   119           3195.24             1         -1.41       2824.47
   120           3185.67         0.041          -110       941.491
   121           3162.15         0.413         -27.2       941.491
   122           3103.68             1         -26.3       941.491
   123            3171.2             1          54.3        313.83
   124           3092.06             1          6.08       627.661
   125           3501.32         0.292      2.08e+03        209.22
   126           6127.05         0.848      1.43e+04        418.44
   127           3060.45             1         -13.5       1673.76
   128           3060.44      0.000462         -12.9       557.921
   129            3038.5             1          32.2       557.921
   130           3049.29             1            28       557.495
   131            3017.9             1          4.09       1114.99
   132           3110.87             1           160       371.663
   133           2985.72             1          22.8       743.326
   134           2972.84         0.121         -9.76       247.775
   135           3158.69             1           315       247.775
   136           2955.06             1            24       495.551
   137           2955.57             1          33.7       462.096
   138           3056.14             1           124       924.192
   139           2943.68             1         -4.69       3696.77
   140           3087.91             1           136       1232.26
   141           2935.88             1         -3.32       2464.51
   142           2931.55             1         -1.47       821.504
   143           2908.45             1         -8.28       273.835
   144           2970.32             1          85.4       91.2782
   145           3323.21             1           817       182.556
   146           2935.98             1            39       730.226
   147           2903.67             1         -1.56       5841.81
   148           2890.37             1         -5.52       1947.27
   149           2890.31       0.00455         -6.74        649.09
   150           2896.45         0.268          25.7        649.09
   151           2866.16         0.145         -76.8       1298.18
   152           2889.44         0.296           104       1298.18
   153           2981.88             1           112       2596.36
   154            2851.3             1         -3.81       10385.4
   155           2446.53         0.803         -76.5       3461.81
   156           2472.13             1           189       3461.81
   157           2663.25         0.883           450       6923.62
   158           2267.32             1         -35.8       27694.5
   159            2186.6             1         -24.1       20565.4
   160           2081.43             1         -43.2       6855.12
   161           2080.34       0.00873         -57.6       2285.04
   162            1968.5             1         -50.1       2285.04
   163           1865.71             1         -35.5       761.681
   164           1845.87         0.137           -60       253.894
   165           1917.57         0.414           509       253.894
   166           1837.88         0.531         -4.08       507.787
   167           1823.11         0.415         -16.2       507.787
   168           2021.59         0.374      1.06e+03       507.787
   169           1784.41             1         -12.4       1015.57
   170           1810.47             1          38.8       338.525
   171           1756.65             1         -8.64       677.049
   172           1750.84             1        -0.806       225.683
   173           1749.88         0.119          1.31       101.092
   174           1962.17             1           276       101.092
   175           1740.56             1         -2.93       202.183
   176           1747.77          0.39          42.4       67.3944
   177           1743.73             1          6.05       134.789
   178           1740.05             1          1.35       539.155
   179           1751.99             1          13.2       386.542
   180           1752.29             1          25.2       773.083
   181           1763.25             1          39.7       3092.33
   182           1735.31             1         -1.92       24738.7
   183           1731.65        0.0356         -48.4       8246.22
   184           1730.67         0.113         -3.74       8246.22
   185           1722.88             1         -2.62       8246.22
   186           1752.38             1          52.6       2748.74
   187           1719.44             1         -1.41       5497.48
   188           1714.53             1         -1.85       1832.49
   189           1719.43             1          5.98       610.831
   190           1757.28             1          87.7       1221.66
   191           1708.69             1         -2.58       4886.65
   192           1848.77             1           164       1628.88
   193           1712.52             1          4.43       3257.77
   194           1707.82             1        -0.369       13031.1

 Optimization terminated: Constrained optimum found.
 Parameters converged to within tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0       1.23115e+06
     1       1.23114e+06      1.95e-05     -3.12e+05      0.556997
     2       1.23113e+06      1.53e-05     -3.12e+05      0.556997
     3       1.23112e+06      1.71e-05     -3.12e+05      0.556997
     4       1.23102e+06      0.000155     -3.11e+05      0.556997
     5        1.2168e+06        0.0255     -2.67e+05      0.556997
     6       1.16722e+06        0.0715     -4.53e+05      0.556997
     7        1.1066e+06         0.144     -1.77e+05      0.556997
     8       1.07626e+06        0.0946     -1.26e+05      0.556997
     9       1.02677e+06         0.271     -4.74e+04      0.556997
    10       1.01105e+06        0.0966     -5.07e+04      0.556997
    11       1.00385e+06        0.0428     -6.09e+04      0.556997
    12            988455         0.336      -4.5e+03      0.556997
    13            982077        0.0696     -2.93e+04      0.556997
    14            654042             1     -9.47e+04      0.556997
    15            269050         0.809     -7.86e+04      0.462472
    16            228637             1     -2.72e+03      0.462472
    17            227724         0.201     -1.95e+03      0.154157
    18            227724      0.000109     -1.79e+03      0.154157
    19            227575        0.0428     -1.68e+03      0.154157
    20            226748         0.447          -673      0.154157
    21            226152             1          -110      0.154157
    22            226011             1           -42     0.0513858
    23            225884         0.183          -347     0.0171286
    24            225720         0.996           286     0.0171286
    25            225618             1         -18.8     0.0171286
    26            225590        0.0225          -611    0.00570953
    27            225343             1           239    0.00570953
    28            225484             1           206    0.00576259
    29            225483             1           205     0.0115252
    30            225475             1           199     0.0461007
    31            225409             1           153      0.368806
    32            225180             1         -1.05       2.95045
    33            225061             1         -10.7       2.95436
    34            224959             1            -8       2.04183
    35            224955             1        -0.608      0.680609
    36            224954             1        -0.205      0.670032
    37            224952       0.00428          -252      0.644015
    38            224885         0.147          -204      0.644015
    39            224693             1         -22.5      0.644015
    40            224668             1         -10.2      0.214672
    41            225900        0.0936      6.62e+05     0.0715573
    42            225894         0.157      3.93e+05      0.143115
    43            225864          0.54      1.13e+05      0.572458
    44            224665             1         -1.16       4.57967
    45            224953             1      7.54e+03       1.52656
    46            224659             1         -5.07       3.05311
    47            225708         0.405      5.53e+04        1.0177
    48            226009         0.667      4.86e+04       2.03541
    49            224658       0.00526          -131       8.14163
    50            224510             1         -23.7       8.14163
    51            225601         0.426      3.02e+04       2.71388
    52            225702         0.733       1.9e+04       5.42775
    53            224466             1         -15.8        21.711
    54            225475         0.763      1.12e+04         7.237
    55            224444             1           170        14.474
    56            224331             1         -20.2        14.474
    57            224290          0.88         -14.7       4.82468
    58            224257             1         -14.3       4.82468
    59            224153             1          15.2       1.60823
    60            224121             1         -0.17      0.536075
    61            224121             1        0.0111      0.178692
    62            224077             1          44.6     0.0595639
    63            224056             1          10.4     0.0581682
    64            224054             1        -0.022     0.0438857
    65            224054             1        -0.119     0.0423848
    66            224053             1       0.00365     0.0186102
    67            224053             1      -0.00849      0.018595
    68            224053             1      -0.00136    0.00984647
    69            224053             1     -0.000943    0.00948068
    70            224000             1         -25.3    0.00655713
    71            223679         0.629          -147    0.00218571
    72            223549             1         -2.59    0.00218571
    73            223538             1          1.28    0.00072857
    74            223538             1          1.25   0.000423289
    75            223538             1         0.737   0.000468037
    76            223537          0.93         0.367   0.000537013
    77            223537             1         0.228   0.000537013
    78            223526             1         -1.93   0.000591143
    79            223519             1         -2.72   0.000197048
    80            223513         0.974          -3.2   6.56825e-05
    81            223504             1         -4.39   6.56825e-05
    82            223502         0.213         -5.67   2.18942e-05
    83            223489             1         -6.91   2.18942e-05
    84            223472             1         -8.54   7.29806e-06
    85            223579         0.564      1.78e+06   2.43269e-06
    86            223456             1         -6.57   4.86537e-06
    87            223573       0.00144      8.08e+07   1.62179e-06
    88            223573       0.00182      6.41e+07   3.24358e-06
    89            223573       0.00407      2.86e+07   1.29743e-05
    90            223573        0.0251      4.64e+06   0.000103795
    91            223569         0.193      6.01e+05   0.000830357
    92            223449             1         -2.72    0.00664286
    93            223556        0.0944      4.29e+05    0.00221429
    94            223555         0.186      2.17e+05    0.00442857
    95            223551         0.738      5.46e+04     0.0177143
    96            223447             1        -0.674      0.141714
    97            223446             1         -0.27     0.0472381
    98            223545         0.199      6.05e+04      0.015746
    99            223545          0.39      3.08e+04     0.0314921
   100            223446             1        -0.397      0.125968
   101            223538         0.209      1.94e+04     0.0419894
   102            223537         0.399      1.01e+04     0.0839788
   103            223445             1        -0.791      0.335915
   104            223520         0.249      5.13e+03      0.111972
   105            223519         0.448      2.84e+03      0.223944
   106            223443             1         -1.06      0.895774
   107            223492         0.395           984      0.298591
   108            223490         0.678           560      0.597183
   109            223441             1        -0.967       2.38873
   110            223468         0.769           208      0.796244
   111            223440             1          5.41       1.59249
   112            223435             1         -1.08       1.59264
   113            223433          0.34         -1.45      0.551973
   114            223428         0.657         -3.94      0.551973
   115            223386             1         -19.9      0.551973
   116            225698          0.94      2.11e+04      0.183991
   117            225699         0.989      2.01e+04      0.367982
   118            223409             1           610       1.47193
   119            223324             1         -27.6       11.7754
   120            223292             1           143       3.92514
   121            223243             1         -4.18       3.94647
   122            223242             1       -0.0182       1.31549
   123            223242             1      -0.00683      0.438496
   124            223242         0.484       -0.0203      0.146165
   125            223242         0.056     -0.000623      0.146165
   126            223242             1     -4.53e-08      0.146165
   127            223241             1         0.038     0.0487218
   128            223225             1          7.85     0.0162406
   129            223223             1        0.0441      0.013637
   130            223220             1       0.00921    0.00454568
   131            223220             1      0.000184    0.00151523
   132            223220             1      -0.00718   0.000505076
   133            223220        0.0884        -0.224   0.000168359
   134            223220         0.387        -0.274   0.000168359
   135            223220             1       -0.0485   0.000168359
   136            222277       0.00212     -2.22e+05   5.61195e-05
   137             61908         0.475     -1.16e+05   5.61195e-05
   138           3138.83         0.813     -1.14e+04   5.61195e-05
   139           998.925             1       0.00485   5.61195e-05
   140           998.877             1        0.0166   1.87065e-05
   141           998.387             1        0.0214   1.63389e-05
   142           998.376             1      0.000159   5.44631e-06
   143           998.375             1      4.71e-06   1.81544e-06

 Optimization terminated: Constrained optimum found.
 Norm of gradient less than tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0       1.06608e+06
     1       1.06606e+06      5.17e-05     -1.49e+05       14226.1
     2            921898         0.791     -2.63e+04       14226.1
     3            912342         0.453     -9.23e+03       14226.1
     4            901514             1     -3.87e+03       14226.1
     5            899859         0.188     -4.19e+03       4742.04
     6            899771        0.0119     -3.69e+03       4742.04
     7            897076         0.409     -2.91e+03       4742.04
     8            893567             1     -1.16e+03       4742.04
     9            891583             1          -669       1580.68
    10            891371          0.12          -866       526.894
    11            890790             1          -201       526.894
    12            890351             1          -159       175.631
    13            890041             1          79.6       58.5437
    14            889947             1         -18.1       22.8228
    15            889925             1          -5.6       7.60759
    16            889922         0.152         -8.25       2.53586
    17            889922       0.00246         -7.91       2.53586
    18            889922       0.00423         -7.89       2.53586
    19            889913             1          2.38       2.53586
    20            889908         0.174         -13.3       2.47829
    21            889895             1         -4.96       2.47829
    22            889872         0.646         -17.6      0.893273
    23            889817         0.642         -42.9      0.893273
    24            889517         0.941          -160      0.893273
    25            885268             1     -2.12e+03      0.893273
    26            883664       0.00368     -2.18e+05      0.297758
    27            863135       0.00902     -1.13e+06      0.297758
    28            859546       0.00551     -3.22e+05      0.297758
    29            857849       0.00392     -2.14e+05      0.297758
    30            851108       0.00545     -6.15e+05      0.297758
    31            845242       0.00535     -5.44e+05      0.297758
    32            297732             1     -6.56e+04      0.297758
    33            292573        0.0302     -8.28e+04     0.0992526
    34            258826         0.301     -4.54e+04     0.0992526
    35            258864        0.0626      9.51e+04     0.0992526
    36            259068        0.0582      1.02e+05      0.198505
    37            257100        0.0732      3.84e+04      0.794021
    38            229147         0.867      9.22e+03      0.794021
    39            229281        0.0101      5.29e+04      0.794021
    40            229271       0.00933      5.71e+04       1.58804
    41            229297        0.0168      3.26e+04       6.35217
    42            234182         0.611      4.11e+04       50.8173
    43            229048        0.0446      1.37e+04       406.539
    44            229044        0.0372         0.249       406.539
    45            241191         0.787      2.17e+04       406.539
    46            230688             1      6.03e+03       813.077
    47            227379             1      3.02e+03       3252.31
    48            225724         0.772          -621        1084.1
    49            230756         0.318      4.36e+04        1084.1
    50            225704        0.0221          -439       2168.21
    51            225445             1           145       2168.21
    52            224964             1          -108       722.735
    53            224796             1          89.1       240.912
    54            224776       0.00896     -1.14e+03       80.3039
    55            224768         0.123         -20.2       80.3039
    56            230084         0.331      6.31e+04       80.3039
    57            229895         0.691      2.93e+04       160.608
    58            225055         0.749      1.59e+03       642.432
    59            224576             1         -88.2       5139.45
    60            224448        0.0157     -2.69e+03       1713.15
    61            229386        0.0963         9e+04       1713.15
    62            224407             1            58        3426.3
    63            224500         0.671           384       2114.81
    64            224264             1           -25       4229.61
    65            224229             1        -0.693       1409.87
    66            224227             1          45.6       469.957
    67            224257             1          74.3       574.586
    68            224195             1          6.12       1149.17
    69            224195             1          12.9       383.058
    70            224178         0.238         -25.1       127.686
    71            225463         0.716      3.14e+03       127.686
    72            224188             1          14.3       255.372
    73            224174             1          8.63       1021.49
    74            224230             1            53       342.409
    75            224295             1           141       684.818
    76            224291             1           167       2739.27
    77            224182             1          40.4       21914.2

 Optimization terminated: Constrained optimum found.
 Parameters converged to within tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0            919223
     1            911508         0.142     -2.49e+04       1.43339
     2            908659        0.0677     -2.02e+04       1.43339
     3            902727         0.172     -1.54e+04       1.43339
     4            901154        0.0621     -1.22e+04       1.43339
     5            900568         0.028     -1.03e+04       1.43339
     6            900098        0.0238     -9.73e+03       1.43339
     7            890711             1          -272       1.43339
     8            889931          0.16     -2.41e+03      0.477796
     9            885922        0.0608     -3.29e+04      0.477796
    10            569236         0.603     -2.04e+05      0.477796
    11            502158         0.103     -3.09e+05      0.477796
    12            221104             1     -1.78e+03      0.477796
    13           23487.9         0.697     -6.73e+04      0.159265
    14           3891.39         0.704      -3.5e+03      0.159265
    15           2660.22         0.403      8.96e+09      0.159265
    16           2205.27             1           212      0.159265
    17           6146.09             1      1.15e+04     0.0530884
    18           2035.18             1         -44.7      0.106177
    19           2033.38      0.000885     -1.02e+03     0.0353923
    20           2033.37      3.91e-05         -81.4     0.0353923
    21           7645.72         0.434      2.99e+04     0.0353923
    22           7629.48         0.344      3.77e+04     0.0707845
    23           7559.42          0.15      8.55e+04      0.283138
    24           7549.27         0.266      4.85e+04        2.2651
    25           7532.81         0.504      2.55e+04       18.1208
    26           7700.97         0.338       3.9e+04       144.967
    27           3048.34             1      1.47e+03       1159.73
    28           2186.12             1           166       9277.87

 Optimization terminated: Constrained optimum found.
 Parameters converged to within tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0       1.09843e+06
     1       1.09842e+06      3.59e-05     -2.02e+05       4.47273
     2        1.0984e+06       4.8e-05     -2.02e+05       4.47273
     3       1.09837e+06      7.76e-05     -2.02e+05       4.47273
     4       1.09822e+06      0.000371     -2.02e+05       4.47273
     5       1.09801e+06      0.000513     -2.02e+05       4.47273
     6        1.0979e+06       0.00029     -2.01e+05       4.47273
     7       1.01257e+06         0.231     -1.67e+05       4.47273
     8            942305          0.36     -7.53e+04       4.47273
     9            935173        0.0719     -4.75e+04       4.47273
    10            929719        0.0636     -4.11e+04       4.47273
    11            894459         0.793     -8.72e+03       4.47273
    12            890969             1          -380       4.47273
    13            890814         0.406          -123       1.49091
    14            890660             1         -39.4       1.49091
    15            890644        0.0534          -142       1.17499
    16            890604          0.12          -158       1.17499
    17            890604      0.000106          -264       1.17499
    18            890566        0.0751          -251       1.17499
    19            890504         0.081          -373       1.17499
    20            890392        0.0897          -622       1.17499
    21            887794             1     -1.29e+03       1.17499
    22            881301        0.0186     -1.74e+05      0.391665
    23            453432             1     -4.85e+04      0.391665
    24            452026        0.0245     -2.86e+04      0.130555
    25            449624       0.00578     -2.07e+05      0.130555
    26            291559         0.458     -1.22e+05      0.130555
    27            224200             1         -24.2      0.130555
    28            224193             1         -1.01     0.0435183
    29            224157             1         -16.5     0.0365688
    30            223893         0.636          -159     0.0121896
    31            223608             1         -68.5     0.0121896
    32            223572             1          27.3     0.0040632
    33            223559             1          8.77    0.00397419
    34            223600         0.996           167    0.00397419
    35            223598             1           159    0.00794839
    36            223580             1           111     0.0317935
    37            223547             1          13.7      0.254348
    38            223539             1          2.68      0.254189
    39            223538             1          1.99      0.232265
    40            223538         0.227        -0.928      0.276957
    41            223538             1          0.41      0.276957
    42            223538             1          0.26      0.311698
    43            223537             1         0.078      0.375025
    44            223534          0.19         -7.35      0.202373
    45            223525             1         -2.67      0.202373
    46            223518             1         -2.91     0.0674578
    47            223511             1         -3.39     0.0224859
    48            223503             1         -4.68    0.00749531
    49            223503      0.000407         -5.87    0.00249844
    50            223490             1         -6.82    0.00249844
    51            223473             1         -8.53   0.000832813
    52            223580         0.543      3.68e+05   0.000277604
    53            223457             1         -6.76   0.000555208
    54            223572        0.0114      1.39e+06   0.000185069
    55            223572        0.0149      1.06e+06   0.000370139
    56            223571         0.036       4.4e+05    0.00148056
    57            223567         0.233      6.77e+04     0.0118444
    58            223449             1            -3     0.0947556
    59            223550         0.253      2.72e+04     0.0315852
    60            223548         0.493      1.39e+04     0.0631704
    61            223446             1        -0.996      0.252682
    62            223537         0.335      9.47e+03     0.0842272
    63            223536         0.645       4.9e+03      0.168454
    64            223445             1         -0.43      0.673817
    65            223526         0.559      3.22e+03      0.224606
    66            223452             1          95.2      0.449212
    67            223445             1        -0.203       1.79685
    68            223447             1            30      0.598949
    69            223445         0.294         0.857        1.1979
    70            223443             1        -0.869        1.1979
    71            223495         0.512           936      0.399299
    72            223494         0.926           509      0.798598
    73            223442             1        -0.562       3.19439
    74            223462             1           137        1.0648
    75            223440             1         -0.81        2.1296
    76            223457         0.712           121      0.709865
    77            223440             1          12.3       1.41973
    78            223439             1        -0.574       5.67892
    79            223437             1         0.507       1.89297
    80            223435         0.614          4.63      0.701199
    81            223422             1         -4.63      0.701199
    82            223311             1          28.7      0.233733
    83            223305        0.0424         -66.5      0.141847
    84            223245             1          8.51      0.141847
    85            223241             1        0.0192     0.0472822
    86            223241             1      0.000266     0.0157607

 Optimization terminated: Constrained optimum found.
 Parameters converged to within tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0            923429
     1            923429      1.62e-05          -219   7.09573e+06
     2            923429      0.000311          -218   7.09573e+06
     3            923420        0.0213          -218   7.09573e+06
     4            923358         0.143          -215   7.09573e+06
     5            922967             1          -189   7.09573e+06

 Optimization terminated: Constrained optimum found.
 Parameters converged to within tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0            982645
     1            982561       0.00047     -8.93e+04       4.92669
     2            982530      0.000174     -8.92e+04       4.92669
     3            982484      0.000258     -8.92e+04       4.92669
     4            982245       0.00134     -8.91e+04       4.92669
     5            982202      0.000239     -8.89e+04       4.92669
     6            981189       0.00571     -8.85e+04       4.92669
     7            978114        0.0176     -8.67e+04       4.92669
     8            933431         0.304     -6.15e+04       4.92669
     9            933309       0.00143     -4.23e+04       4.92669
    10            921535         0.156     -3.36e+04       4.92669
    11            915457          0.11     -2.52e+04       4.92669
    12            910328         0.117     -1.99e+04       4.92669
    13            902857         0.238     -1.27e+04       4.92669
    14            899066         0.187     -8.57e+03       4.92669
    15            899003        0.0038     -8.17e+03       4.92669
    16            894340         0.419     -3.64e+03       4.92669
    17            891776         0.629          -978       4.92669
    18            891396          0.19          -787       4.92669
    19            891310        0.0477          -845       4.92669
    20            890511             1          -210       4.92669
    21            890472        0.0182     -1.07e+03       3.99839
    22            890182        0.0276      4.88e+05       3.99839
    23            888214             1          -854       3.99839
    24            834927             1     -2.59e+04       2.49473
    25            756649        0.0633     -5.95e+05      0.831576
    26            647575         0.073      -7.1e+05      0.831576
    27            621037        0.0218     -5.99e+05      0.831576
    28            594371        0.0162     -8.09e+05      0.831576
    29            524178        0.0966     -1.09e+05      0.831576
    30            144342         0.506     -2.42e+05      0.831576
    31            138546        0.0205      -1.4e+05      0.831576
    32            121144        0.0951     -8.39e+04      0.831576
    33           27081.3         0.608     -4.21e+04      0.831576
    34           8700.68             1          -996      0.831576
    35           8297.39             1          -113      0.277192
    36             12234         0.913      8.26e+03     0.0923973
    37           10112.1         0.511      1.19e+04      0.184795
    38           10210.5         0.543      1.14e+04      0.739179
    39           23666.8         0.243      7.83e+04       5.91343
    40           6472.01             1           197       47.3074
    41           7989.96             1      1.53e+03       15.7691
    42           8092.11             1      1.69e+03       31.5383
    43            8234.3             1      2.02e+03       126.153
    44           6087.11             1           856       1009.23
    45           5916.96         0.056     -1.35e+03       336.408
    46           5909.19        0.0107          -345       336.408
    47           5266.27         0.492          -471       336.408
    48           5407.38             1           633       336.408
    49           5179.59             1           212       672.817
    50           5105.79         0.219          -146       638.417
    51           6995.31         0.639      6.47e+03       638.417
    52           5464.31             1           660       1276.83
    53           5088.01         0.254         -32.5       5107.34
    54           5070.75             1         -2.31       5107.34
    55           5094.82             1           198       1702.45
    56            5010.6             1            48       3404.89
    57           4785.55             1         -10.5       1134.96
    58           4778.88        0.0129          -240       578.549
    59            6220.8             1      2.71e+03       578.549
    60           8487.98         0.468      1.86e+04        1157.1
    61             48299         0.272      7.12e+05        4628.4

 Optimization terminated: Constrained optimum found.
 Parameters converged to within tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0            926434
     1            926426       0.00127     -3.13e+03        396512
     2            922385             1          -892        396512
     3            917315             1     -2.37e+03        132171
     4            908430             1     -3.77e+03       44056.8
     5            908340       0.00771     -5.83e+03       14685.6
     6            907908        0.0375     -5.71e+03       14685.6
     7            906783         0.103     -5.36e+03       14685.6
     8            898755             1     -2.91e+03       14685.6
     9            893948             1     -1.53e+03        4895.2
    10            892277         0.624     -1.09e+03       1631.73
    11            891032             1          -454       1631.73
    12            891007        0.0176          -689       543.912
    13            890639             1          -116       543.912
    14            890288         0.731          -189       181.304
    15            890235         0.272         -92.6       181.304
    16            890098             1         -55.4       181.304
    17            889991             1         -27.5       60.4346
    18            889954             1         -9.17       20.1449
    19            889940         0.899         -5.64       6.71496
    20            889940        0.0189         -4.36       6.71496
    21            889932             1         -3.86       6.71496
    22            889920         0.559         -7.61       2.23832
    23            889907             1         -5.47       2.23832
    24            889887         0.374         -26.5      0.746106
    25            889861         0.212         -59.7      0.746106
    26            889831         0.123          -122      0.746106
    27            889794        0.0818          -226      0.746106
    28            889218         0.725          -397      0.746106
    29            889175       0.00232     -9.14e+03      0.746106
    30            870316             1      -9.3e+03      0.746106
    31            870312      1.43e-05      -1.4e+05      0.248702
    32            870293      1.42e-05     -6.71e+05      0.248702
    33            870284      2.26e-05     -2.13e+05      0.248702
    34            867000       0.00371     -4.42e+05      0.248702
    35            689660          0.32     -2.19e+05      0.248702
    36            687442        0.0049     -2.26e+05      0.248702
    37            578529         0.278      -1.6e+05      0.248702
    38            573026        0.0073     -3.72e+05      0.248702
    39            564020          0.01     -4.32e+05      0.248702
    40            527448        0.0748     -1.74e+05      0.248702
    41            532413      0.000813      2.85e+07      0.248702
    42            532415       0.00082      2.83e+07      0.497404
    43            532422       0.00085      2.72e+07       1.98962
    44            532500       0.00114      2.01e+07       15.9169
    45            529874       0.00715      2.89e+06       127.336
    46            522046        0.0307      4.27e+05       1018.68
    47            493673        0.0745     -1.36e+05       1018.68
    48            482315        0.0302     -1.85e+05       1018.68
    49            391879         0.239      -1.7e+05       1018.68
    50            324403         0.262     -1.11e+05       1018.68
    51            251109         0.399      1.08e+04       1018.68
    52            231653             1     -1.12e+03       1018.68
    53            267457         0.282      6.86e+05       339.561
    54            261546         0.127      1.08e+06       679.123
    55            263680         0.581      2.74e+05       2716.49
    56            229744             1          -586       21731.9
    57            229129             1          -219       7243.98
    58            229063        0.0744          -419       2414.66
    59            228631             1           206       2414.66
    60            228477             1         -16.7       804.886
    61            228408         0.669         -31.5       268.295
    62            228356             1         -10.1       268.295
    63            228409             1           109       89.4318
    64            228355         0.661          42.1       178.864
    65            228347       0.00278     -1.97e+03       178.864
    66            228322             1          6.66       178.864
    67            236014             1      1.62e+04       59.6212
    68            228344             1          21.5       119.242
    69            228366         0.326           115        476.97
    70            228333             1           9.5       3815.76

 Optimization terminated: Constrained optimum found.
 Parameters converged to within tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0            940316
     1            940309      6.37e-05     -5.03e+04       2.76561
     2            940302      7.14e-05     -5.03e+04       2.76561
     3            940289       0.00013     -5.02e+04       2.76561
     4            940275      0.000141     -5.02e+04       2.76561
     5            940268      6.91e-05     -5.02e+04       2.76561
     6            940249      0.000194     -5.02e+04       2.76561
     7            940240      9.05e-05     -5.02e+04       2.76561
     8            940130       0.00109     -5.01e+04       2.76561
     9            940040      0.000901        -5e+04       2.76561
    10            940027      0.000128        -5e+04       2.76561
    11            939848       0.00179     -4.98e+04       2.76561
    12            939528       0.00322     -4.95e+04       2.76561
    13            933996        0.0614     -4.14e+04       2.76561
    14            915154         0.303     -2.24e+04       2.76561
    15            911197        0.0514     -4.67e+06       2.76561
    16            899007         0.506     -6.82e+03       2.76561
    17            898993      0.000721     -9.77e+03       2.76561
    18            898134        0.0506     -7.41e+03       2.76561
    19            895935         0.182      -4.3e+03       2.76561
    20            887878             1     -2.92e+03       2.76561
    21            639221             1     -1.03e+05       2.64359
    22            636754       0.00449     -2.39e+05      0.881196
    23            621400       0.00114     -6.66e+06      0.881196
    24            602829        0.0159     -5.78e+05      0.881196
    25            597815       0.00707     -3.54e+05      0.881196
    26            587827       0.00031      -1.6e+07      0.881196
    27            583768       0.00551     -3.67e+05      0.881196
    28            547576        0.0313     -5.67e+05      0.881196
    29           76014.8         0.519     -2.14e+05      0.881196
    30           42566.6         0.264      -4.9e+04      0.881196
    31           27804.1             1      4.36e+04      0.881196
    32           16573.8         0.405     -6.48e+03      0.293732
    33           24961.1         0.184      2.56e+05      0.293732
    34           24943.7         0.184      2.55e+05      0.587464
    35           24887.5         0.185      2.54e+05       2.34986
    36           24613.2         0.179      2.64e+05       18.7988
    37           26547.2        0.0185      2.43e+06       150.391
    38           22327.1             1      1.03e+04       1203.13
    39           23936.3             1      1.29e+04       9625.01
    40           9006.85             1     -2.77e+03       77000.1
    41           6392.74             1          -658       25666.7
    42           4974.07             1          -358       8555.57
    43           4634.55          0.42           423       2851.86
    44           4532.83          0.32          -108       2851.86
    45           4582.95             1          61.4       2851.86
    46           4465.24             1        -0.409       5703.71
    47           4356.66             1         -38.8       1901.24
    48           4561.04             1           292       633.746
    49           4406.78             1           115       1267.49
    50           4323.62             1           -11       5069.96
    51           4284.85             1         -10.2       1689.99
    52           4524.83         0.066      5.52e+03       563.329
    53           4278.24             1          7.56       1126.66
    54           4266.24             1          -1.5       375.553
    55            4262.8             1         -0.91       125.184
    56           4261.49             1        -0.162       41.7281
    57            4260.7             1        -0.291       13.9094
    58           4259.44             1        -0.502       5.54311
    59           4258.02             1        -0.602       3.07959
    60            4257.8         0.099         -1.09       1.57547
    61           4255.76             1        -0.934       1.57547
    62           4246.71             1         -4.35      0.549232
    63            4246.7      1.14e-05          -252      0.183077
    64           4175.78         0.126         -11.1      0.183077
    65           4844.23          0.25      2.65e+04      0.183077
    66           4771.44        0.0745      8.44e+04      0.366154
    67           4706.48        0.0152      3.97e+05       1.46462
    68           4837.16             1      1.54e+03       11.7169
    69           4130.39             1         -12.8       93.7355
    70           3915.98             1         -25.5       31.2452
    71           3957.63             1           417       10.4151
    72           3882.17             1          48.9       20.8301
    73           3786.74         0.774         -30.5       18.4343
    74            3742.4             1         -4.21       18.4343
    75           3719.96         0.022      1.14e+03       6.14478
    76           3550.56         0.485           265       6.14478
    77           4455.19         0.303      1.59e+04       6.14478
    78           4496.47         0.356      1.34e+04       12.2896
    79           9480.87             1       1.2e+04       49.1582
    80           3440.03             1         -18.2       393.266
    81           3395.72         0.297         -61.3       175.728
    82           3442.53             1          78.2       175.728
    83           3408.45             1            46       351.455
    84              3337             1         -22.7       1405.82
    85           3410.48             1           104       468.607
    86           3365.31             1          34.2       937.214
    87           3349.94             1          14.2       3748.86

 Optimization terminated: Constrained optimum found.
 Parameters converged to within tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0            925564
     1            925563      5.11e-05     -5.32e+03    1.3345e+06
     2            925563       1.6e-05     -2.02e+03    1.3345e+06
     3            925562      0.000166      -1.9e+03    1.3345e+06
     4            925527       0.00921     -1.89e+03    1.3345e+06
     5            923116         0.699     -1.57e+03    1.3345e+06
     6            922637         0.183     -1.28e+03    1.3345e+06
     7            920435             1          -969    1.3345e+06
     8            917393             1     -1.23e+03        444834
     9            915231         0.472     -2.17e+03        148278
    10            911570             1     -1.68e+03        148278
    11            905052             1     -2.81e+03         49426
    12            897655             1     -2.75e+03       16475.3
    13            893164             1     -1.37e+03       5491.78
    14            891752         0.671          -825       1830.59
    15            890808             1          -367       1830.59
    16            890695        0.0966          -572       610.198
    17            890495             1         -77.8       610.198
    18            890417         0.391         -90.6       203.399
    19            890359          0.42         -62.8       203.399
    20            890283             1           -28       203.399
    21            890196             1         -34.2       67.7998
    22            890105             1         -19.1       22.5999
    23            890076         0.568         -18.1        12.812
    24            890057         0.963         -5.47        12.812
    25            890053             1         -1.29        12.812
    26            889987             1          7.53       4.27067
    27            889965             1         -6.64       2.56627
    28            889926             1         -11.7      0.855422
    29            889920        0.0804         -38.3       0.52786
    30            889916        0.0406         -45.4       0.52786
    31            889826             1         -43.3       0.52786
    32            887679             1     -1.07e+03      0.175953
    33            887186       0.00127     -1.95e+05     0.0586511
    34            887134      0.000108     -2.36e+05     0.0586511
    35            883603       0.00176        -1e+06     0.0586511
    36            570292             1     -1.29e+05     0.0586511
    37            556018        0.0228     -3.07e+05     0.0195504
    38            550158        0.0103     -1.24e+05     0.0195504
    39            534027        0.0321     -2.43e+05     0.0195504
    40            513305        0.0257     -3.93e+05     0.0195504
    41            366648         0.352     -1.68e+05     0.0195504
    42            353500        0.0534     -1.16e+05     0.0195504
    43            294314         0.308     -7.92e+04     0.0195504
    44            287575        0.0789      8.31e+04     0.0195504
    45            313773        0.0163      2.01e+06     0.0195504
    46            314981        0.0166      1.77e+07     0.0391008
    47            314979        0.0166      1.76e+07      0.156403
    48            315040        0.0102      2.85e+07       1.25122
    49            315940       0.00594      5.01e+07       10.0098
    50            316546       0.00742      4.08e+07       80.0783
    51            320011        0.0199      1.69e+07       640.627
    52            248407             1     -4.76e+03       5125.01
    53            264400         0.703      7.19e+05       1708.34
    54            266384         0.651      8.17e+05       3416.68
    55            241728             1     -2.25e+03       13666.7
    56            258289         0.583      9.19e+05       4555.57
    57            239576          0.46     -1.99e+03       9111.14
    58            237272             1          -943       9111.14
    59            235594             1          -124       3037.05
    60            232714             1          -706       1012.35
    61            232330         0.411          33.6       337.449
    62            252781         0.393      1.05e+09       337.449
    63            251857         0.783      5.24e+08       674.899
    64            231899             1         -82.8        2699.6
    65            231989        0.0375         4e+03       899.865
    66            251038         0.376      2.17e+09       1799.73
    67            231026             1          -225       7198.92
    68            230445             1          -155       2399.64
    69            252999        0.0754       2.8e+10        799.88
    70            252902         0.166      1.27e+10       1599.76
    71            230787             1           553       6399.04
    72            230208             1          -112       51192.3
    73            229951             1          -110       17064.1
    74            229722             1          96.4       5688.04
    75            229556         0.481          -140        5354.3
    76            229295             1           -88        5354.3
    77            229322             1           239       1784.77
    78            228992             1          -118       3569.54
    79            228567         0.713          -259       1189.85
    80            228185         0.605          -275       1189.85
    81            227497             1          -194       1189.85
    82            226843             1         -36.9        417.81
    83            226556             1         -41.9       320.368
    84            226878         0.735           886       106.789
    85            226605             1           190       213.579
    86            226515             1          19.8       854.314
    87            227093             1      1.02e+03       284.771
    88            226709             1           327       569.543
    89            226535             1          62.5       2278.17
    90            225921             1         -91.7       18225.4
    91            225785             1         -23.4       14264.4
    92            225784        0.0145         -24.7        9031.2
    93            225754             1         -7.78        9031.2
    94            225797             1          47.6        3010.4
    95            225763             1          16.1        6020.8
    96            225737             1         -7.02       24083.2
    97            225755             1          22.1       8027.74
    98            225723             1         -3.21       16055.5
    99            225738             1          22.1       5351.82
   100            225828             1           151       10703.6
   101            181526         0.106     -1.97e+05       42814.6
   102           6204.32         0.886     -2.12e+04       42814.6
   103            3571.1             1         -58.7       42814.6
   104           3505.78             1         -20.2       14271.5
   105           3413.21             1         -42.2       4757.18
   106           3330.28             1         -9.35       1585.73
   107           3596.81             1           308       528.575
   108           3524.47             1           258       1057.15
   109           3364.36             1          52.6        4228.6

 Optimization terminated: Constrained optimum found.
 Parameters converged to within tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0            942143
     1            936245        0.0645     -3.98e+04      0.563164
     2            935246         0.011     -4.36e+04      0.563164
     3            931740         0.044     -3.49e+04      0.563164
     4            915433         0.387     -1.25e+04      0.563164
     5            898532             1     -4.31e+03      0.563164
     6           98499.6             1     -1.34e+05      0.563367
     7           71722.3         0.153     -7.89e+04      0.187789
     8           3874.81             1     -2.14e+03      0.187789
     9           3213.03         0.133      -2.2e+03     0.0625963
    10           1132.47             1          -219     0.0625963
    11           1115.08         0.178           -44     0.0208654
    12           1076.92             1         -1.48     0.0208654
    13           1021.63             1         -14.4    0.00695515
    14            1010.1             1        -0.315    0.00231838
    15           1004.41             1          15.4   0.000772794
    16           998.406             1         -0.16   0.000772794
    17           998.379             1       0.00628   0.000257598
    18           998.377             1      0.000922   0.000187074
    19           998.371             1      -0.00135   0.000176568
    20            998.37             1      6.85e-05    6.9036e-05

 Optimization terminated: Constrained optimum found.
 Norm of gradient less than tolerance.
Warning: LSQLIN did not converge. Infeasible network contraints.
> In mylsqlin
In multistart
In multistart
In estimate
In inca_script (line 234)
Warning: Network is ill-conditioned.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0       5.47631e+15

 Maximum lambda value exceeded.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0            963309
     1            963295      9.61e-05     -7.25e+04       2.14069
     2            963284      7.43e-05     -7.25e+04       2.14069
     3            963280      2.66e-05     -7.25e+04       2.14069
     4            963268      8.02e-05     -7.25e+04       2.14069
     5            963255      9.42e-05     -7.25e+04       2.14069
     6            963241      9.23e-05     -7.25e+04       2.14069
     7            962522       0.00498     -7.19e+04       2.14069
     8            961936        0.0041     -7.13e+04       2.14069
     9            934241         0.228     -5.14e+04       2.14069
    10            920583          0.17     -3.61e+04       2.14069
    11            891258             1     -2.12e+03       2.14069
    12            890860          0.28          -362      0.713564
    13            890732        0.0844          -620      0.713564
    14            890729        0.0019          -870      0.713564
    15            890152             1          -142      0.713564
    16            885246             1     -2.41e+03      0.711964
    17            885213      4.44e-05     -3.77e+05      0.237321
    18            404145             1     -1.03e+05      0.237321
    19            400580        0.0128      5.22e+08     0.0791071
    20            399368       0.00347     -1.73e+05     0.0791071
    21            391449        0.0247     -1.15e+05     0.0791071
    22            378002        0.0406      -1.6e+05     0.0791071
    23            376462        0.0039     -1.95e+05     0.0791071
    24            375846       0.00352     -8.68e+04     0.0791071
    25            325726         0.143     -1.55e+05     0.0791071
    26            326364        0.0293      2.19e+05     0.0791071
    27            326300        0.0296      2.16e+05      0.158214
    28            326373        0.0292       2.2e+05      0.632857
    29            306590         0.141     -5.82e+04       5.06285
    30            305220      8.64e-05     -7.74e+06       5.06285
    31            289057        0.0909     -8.05e+04       5.06285
    32            271740         0.229      -3.3e+04       5.06285
    33            260743        0.0229      1.44e+03       5.06285
    34            257066        0.0615      2.08e+03       5.06285
    35            244832         0.851     -1.39e+03       5.06285
    36            229270             1      6.08e+03       5.06285
    37            226696             1          -195       1.68762
    38            226768             1           214      0.562539
    39            226767             1           212       1.12508
    40            226776             1           224       4.50031
    41            231873          0.25      5.28e+04       36.0025
    42            226654             1           120        288.02
    43            226654      5.89e-05         -53.5       96.0067
    44            226603             1          11.5       96.0067
    45            226598             1         -1.54       32.0022
    46            226598        0.0251         -1.63       10.6674
    47            226596             1        -0.411       10.6674
    48            226596        0.0532         -0.38        3.5558
    49            226595             1        -0.492        3.5558
    50            226596             1         0.813       1.18527
    51            226595             1         0.786       2.37054
    52            226594             1         0.519      0.790178
    53            226583        0.0367          -149      0.263393
    54            226597             1          37.6      0.263393
    55            226596             1          36.3      0.526786
    56            226596             1          35.9       2.10714
    57            226484             1         -4.06       16.8571
    58            226392         0.503         -29.7        14.264
    59            226374         0.164         -53.8        14.264
    60            226346             1          9.75        14.264
    61            226342             1          19.1       4.75465
    62            226427             1           102       4.75516
    63            226422             1          95.8       9.51032
    64            226412             1          80.1       38.0413
    65            226480             1           123        304.33
    66            226279             1         -18.2       2434.64
    67            226272             1            19       811.547
    68            226254             1         0.944       811.327
    69            226266             1          22.7       270.442
    70            226262             1          12.4       540.884
    71            226241             1         -5.49       2163.54
    72            226228             1            -4       721.179
    73            226226             1        0.0515       240.393
    74            226222        0.0625         -22.5        80.131
    75            226224         0.962          2.95        80.131
    76            226223             1          2.39       160.262
    77            226224             1          2.09       641.048
    78            226214             1           9.4       5128.39
    79            226159             1         -14.4       2684.89
    80            226083             1         -33.8       894.964
    81            226081        0.0634         -15.2       298.321
    82            225911             1         -20.4       298.321
    83            225900        0.0424          -130       203.378
    84            225734         0.926         -72.7       203.378
    85            225585             1         -56.9       203.378
    86            225564         0.193           -50       67.7927
    87            225559        0.0374         -67.9       67.7927
    88            226994         0.928      2.45e+03       67.7927
    89            226037             1       1.2e+03       135.585
    90            225762             1           257       542.341
    91            225539             1          -8.7       4338.73
    92            225521             1          1.54       1446.24
    93            225960             1           876       482.081
    94            226672         0.687      3.23e+03       964.162
    95            248571         0.963      2.47e+04       3856.65

 Optimization terminated: Constrained optimum found.
 Parameters converged to within tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0            977083
     1            977080      1.96e-05     -8.29e+04       1.32973
     2            977069      6.43e-05     -8.28e+04       1.32973
     3            977068      1.09e-05     -8.28e+04       1.32973
     4            977043      0.000146     -8.28e+04       1.32973
     5            954699          0.15     -6.61e+04       1.32973
     6            952294        0.0203     -5.73e+04       1.32973
     7            933387         0.223     -3.09e+04       1.32973
     8            924888         0.131     -2.57e+04       1.32973
     9            923255        0.0272     -2.82e+04       1.32973
    10            905385          0.88     -2.04e+03       1.32973
    11            899436             1     -1.61e+03       1.32973
    12            841894         0.273     -1.03e+05       1.36015
    13           86400.7             1      -6.4e+04       1.36015
    14             85777       0.00378     -8.22e+04      0.453385
    15           6589.23             1     -1.28e+03      0.453385
    16           6561.68       0.00429      -3.2e+03      0.151128
    17           5861.81         0.115     -2.88e+03      0.151128
    18           4460.54         0.177     -3.95e+03      0.151128
    19           3252.86         0.201     -2.78e+03      0.151128
    20           1747.43             1      2.47e+03      0.151128
    21           1244.99             1         -68.9      0.134219
    22           1212.84         0.816         -7.06     0.0483188
    23           1210.77             1        -0.186     0.0483188
    24           1206.38         0.876          -2.5     0.0161063
    25           1165.09         0.209         -94.8     0.0161063
    26           1122.72             1          20.2     0.0161063
    27           1098.99             1        -0.236    0.00696545
    28           1097.94             1         0.025    0.00289157
    29           1097.94        0.0564       -0.0233   0.000963856
    30           1097.92             1       0.00422   0.000963856

 Optimization terminated: Constrained optimum found.
 Parameters converged to within tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0       1.19918e+06
     1       1.19917e+06      1.03e-05     -2.77e+05        53.213
     2       1.19074e+06        0.0159     -2.52e+05        53.213
     3       1.18913e+06       0.00301     -2.66e+05        53.213
     4       1.18215e+06        0.0135     -2.52e+05        53.213
     5        1.0995e+06         0.236     -1.06e+05        53.213
     6        1.0732e+06         0.072     -1.68e+05        53.213
     7            953703         0.551     -6.21e+04        53.213
     8            945741        0.0673     -5.72e+04        53.213
     9            923029         0.248     -3.86e+04        53.213
    10            891747             1     -2.87e+03        53.213
    11            890792             1         -89.2       17.7377
    12            890691             1         -20.2       6.91566
    13            890642             1           -22       2.30522
    14            890327         0.918          -172      0.768407
    15            890191        0.0244     -2.79e+03      0.768407
    16            884145         0.623     -4.84e+03      0.768407
    17            846289        0.0567     -3.29e+05      0.768407
    18            789948        0.0473     -5.81e+05      0.768407
    19            748516        0.0374     -5.43e+05      0.768407
    20            680489        0.0672     -4.88e+05      0.768407
    21            224088             1          -358      0.768407
    22            224084         0.254         -5.56      0.256136
    23            224080             1        0.0106      0.256136
    24            224080             1        0.0101     0.0853786
    25            224080             1       -0.0102     0.0760233
    26            224080             1       -0.0259     0.0451183
    27            224080             1        -0.135     0.0150394
    28            224076         0.513         -3.04    0.00501314
    29            224060             1         0.885    0.00501314
    30            224060        0.0444         0.206    0.00220663
    31            224056             1         0.486    0.00220663
    32            224055             1       -0.0752   0.000735544
    33            224055             1        -0.011   0.000245181

 Optimization terminated: Constrained optimum found.
 Parameters converged to within tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0       1.07571e+06
     1            950338         0.381     -1.36e+05       1.19133
     2            944973        0.0481     -5.12e+04       1.19133
     3            934624         0.119     -3.44e+04       1.19133
     4            924808         0.155     -2.24e+04       1.19133
     5            922621        0.0359     -2.66e+04       1.19133
     6            910669             1           645       1.19133
     7            908330        0.0518     -1.73e+04        1.2177
     8            789913             1     -5.56e+04        1.2177
     9            645453         0.109     -6.22e+05      0.605915
    10           17386.8             1     -2.42e+03      0.605915
    11           16061.5        0.0424     -1.51e+04      0.201972
    12           2174.94             1     -1.87e+03      0.201972
    13           1179.79             1          -124     0.0720022
    14           1126.25             1         -1.55     0.0240007
    15           1124.63         0.359         -1.93    0.00800024
    16           1093.21             1         -7.18    0.00800024
    17           2066.29         0.804      3.25e+03    0.00266675
    18           2066.35         0.804      3.24e+03    0.00533349
    19           2066.65         0.808      3.23e+03      0.021334
    20           2069.53         0.837      3.13e+03      0.170672
    21           1785.49             1      1.78e+03       1.36537
    22           1078.47             1          9.29        10.923
    23           1070.01             1             8       10.8987
    24           1056.67             1         -2.71       11.1069
    25           1054.44             1      -0.00341       6.18391
    26           1052.55             1        -0.508       6.17879
    27            1051.8             1        -0.188       3.89993
    28            1051.3             1        -0.173       3.71953
    29           1050.98             1        -0.116       2.82924
    30           1050.74             1       -0.0881       2.36395
    31           1050.56             1       -0.0683       1.87512
    32           1050.42             1       -0.0542       1.48904
    33           1050.31             1       -0.0433       1.17555
    34           1050.22             1       -0.0348      0.927307
    35           1050.15             1       -0.0279      0.731584
    36            1050.1             1       -0.0224      0.577606
    37           1050.05             1        -0.018      0.456458
    38           1050.01             1       -0.0144      0.361053
    39           1049.98             1       -0.0115      0.285828
    40           1049.96             1       -0.0092      0.226442
    41           1049.94             1      -0.00734      0.179505
    42           1049.93             1      -0.00586      0.142371
    43           1049.92             1      -0.00467      0.112967
    44           1049.91             1      -0.00372     0.0896666
    45            1049.9             1      -0.00296     0.0711924
    46           1049.89             1      -0.00236     0.0565374
    47           1049.89             1      -0.00188     0.0449073
    48           1049.88             1      -0.00149     0.0356749
    49           1049.88             1     -0.000962     0.0283439

 Optimization terminated: Constrained optimum found.
 Norm of gradient less than tolerance.
Warning: LSQLIN did not converge. Infeasible network contraints.
> In mylsqlin
In multistart
In multistart
In estimate
In inca_script (line 234)

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0       2.22218e+15
     1       2.22218e+15             1     -3.93e+04        100098
     2       2.22218e+15         0.829     -2.81e+04       33366.1
     3       2.22218e+15         0.744      -8.6e+03       33366.1
     4       2.22218e+15         0.459      -4.1e+03       33366.1
     5       2.22218e+15             1     -1.83e+03       33366.1
Warning: Network is ill-conditioned.
     6       2.22218e+15         0.596     -1.57e+03         11122
Warning: Network is ill-conditioned.
     7       2.22218e+15         0.657     -1.23e+03         11122
Warning: Network is ill-conditioned.
     8       2.22218e+15             1          -843         11122
     9       2.22218e+15             1     -1.38e+03       3707.35
    10       2.22218e+15             1     -1.22e+03       1235.78
Warning: Network is ill-conditioned.
    11       2.22218e+15             1         -40.6        432.61
Warning: Network is ill-conditioned.
    12       2.22218e+15             1         -19.4       362.208
Warning: Network is ill-conditioned.
    13       2.22218e+15             1         -42.9       141.514
Warning: Network is ill-conditioned.
    14       2.22218e+15         0.211         -1.15       137.449
Warning: Network is ill-conditioned.
    15       2.22218e+15             1         -1.57       137.449
Warning: Network is ill-conditioned.
    16       2.22218e+15             1        -0.184       128.155
Warning: Network is ill-conditioned.
    17       2.22218e+15             1          -2.1       108.868
    18       2.22218e+15             1         0.214       162.437
    19       2.22218e+15             1          1.39       324.874
Warning: Network is ill-conditioned.
    20       2.22218e+15             1        -0.241       108.291
    21       2.22218e+15             1          -1.5       117.798
Warning: Network is ill-conditioned.
    22       2.22218e+15             1         -3.46       39.2661
Warning: Network is ill-conditioned.
    23       2.22218e+15             1         -1.79       78.5322
    24       2.22218e+15             1        -0.654       314.129

 Optimization terminated: Constrained optimum found.
 Parameters converged to within tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0            927410
     1            927409      1.42e-05     -3.82e+04       1.06468
     2            908796         0.301     -2.45e+04       1.06468
     3            904437         0.122     -1.62e+04       1.06468
     4            901136         0.118     -1.26e+04       1.06468
     5            901063       0.00298     -1.22e+04       1.06468
     6            900127        0.0437     -1.03e+04       1.06468
     7            892433         0.683     -2.35e+03       1.06468
     8            891772         0.163     -1.49e+03       1.06468
     9            891021         0.226     -1.19e+03       1.06468
    10            885101             1     -2.66e+03       1.06468
    11            883076       0.00315     -3.21e+05      0.679007
    12            359099             1     -1.26e+05      0.679007
    13            341751        0.0248     -3.37e+05      0.226336
    14           2878.85             1      -2.6e+03      0.226336
    15            1099.4             1         -3.37     0.0754452
    16           1074.83             1          -2.2     0.0251484
    17           1065.26             1          -4.1     0.0083828
    18           1043.52         0.184         -53.8    0.00279427
    19           1004.81             1            16    0.00279427
    20           999.031             1        -0.136     0.0016385
    21           998.924             1        -0.001   0.000546165
    22           998.882          0.46       -0.0272   0.000182055
    23            998.87             1        0.0014   0.000182055

 Optimization terminated: Constrained optimum found.
 Parameters converged to within tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0       1.03222e+06
     1       1.02735e+06        0.0205     -1.01e+05      0.566358
     2            993939         0.161      -8.7e+04      0.566358
     3            955485         0.571     -1.02e+04      0.566358
     4            953023        0.0245     -3.85e+04      0.566358
     5            950120        0.0341     -2.84e+04      0.566358
     6            945196         0.112     -1.02e+04      0.566358
     7            849572         0.694     -6.48e+04      0.566358
     8            116848             1     -1.66e+04      0.566358
     9           2991.23             1     -2.69e+03      0.188786
    10           1631.53         0.566          -700     0.0629287
    11           1177.88             1         -48.6     0.0629287
    12              1163             1        -0.658     0.0209762
    13           1160.35             1         -1.21    0.00699208
    14            1151.7             1          1.85    0.00233069
    15           1151.16             1         0.169    0.00161808
    16           1151.12             1        0.0186    0.00141595
    17           1151.12             1       0.00212    0.00134597
    18           1066.44             1          9.33    0.00129823
    19           1058.31             1        -0.374   0.000592779
    20           1056.91        0.0643         -10.6   0.000197593
    21           1052.45             1          15.6   0.000197593
    22           1051.54        0.0771         -5.68   0.000197975
    23           1046.27             1        -0.174   0.000197975
    24           1046.26             1      0.000165   6.59918e-05

 Optimization terminated: Constrained optimum found.
 Parameters converged to within tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0       1.07675e+06
     1       1.07675e+06      2.08e-05     -1.81e+05       2.68989
     2       1.07674e+06      1.11e-05     -1.81e+05       2.68989
     3       1.07673e+06      2.45e-05     -1.81e+05       2.68989
     4       1.07673e+06      1.11e-05     -1.81e+05       2.68989
     5       1.07671e+06      4.54e-05     -1.81e+05       2.68989
     6       1.03098e+06          0.17     -9.96e+04       2.68989
     7       1.00814e+06        0.0908     -1.15e+05       2.68989
     8            997185        0.0498     -1.04e+05       2.68989
     9            936896          0.42     -4.69e+04       2.68989
    10            918296         0.271     -2.59e+04       2.68989
    11            908007         0.187     -4.01e+04       2.68989
    12            899668         0.387     -6.41e+03       2.68989
    13            894728         0.967      7.53e+03       2.68989
    14            894699       0.00215     -6.57e+03       2.68989
    15            889072             1     -2.27e+03       2.68989
    16            680635             1     -8.61e+04       2.60641
    17            680503      0.000227     -2.91e+05      0.868804
    18            680461      6.31e-05     -3.31e+05      0.868804
    19            673924        0.0104     -3.13e+05      0.868804
    20            654962        0.0304     -3.08e+05      0.868804
    21            627541        0.0528      2.11e+06      0.868804
    22            576084        0.0193     -1.26e+06      0.868804
    23            529149        0.0758     -1.89e+10      0.868804
    24            490712        0.0547     -3.35e+05      0.868804
    25            392397         0.235     -1.82e+05      0.868804
    26            389730        0.0319      8.85e+05      0.868804
    27            294035        0.0127      -1.3e+06      0.868804
    28            280718             1     -5.11e+03      0.868804
    29            265069             1     -6.48e+03      0.289601
    30            247263             1      -5.8e+03     0.0965338
    31            245088         0.964       6.5e+03     0.0321779
    32            241668             1          -852     0.0321779
    33            238842             1           600      0.010726
    34            238099             1          -150    0.00357533
    35            237965         0.153          -226    0.00292667
    36            251169         0.052      2.98e+07    0.00292667
    37            251203        0.0531      2.92e+07    0.00585334
    38            242777        0.0033      3.25e+08     0.0234133
    39            250636        0.0738      2.05e+07      0.187307
    40            249564         0.173      8.14e+06       1.49845
    41            250036         0.963      1.41e+06       11.9876
    42            237907             1         -20.6        95.901
    43            237713             1          -158        31.967
    44            253279         0.636      5.23e+05       10.6557
    45            253269         0.867      3.84e+05       21.3113
    46            237505             1          -136       85.2454
    47            237438             1           519       28.4151
    48            237299             1           -19       29.1836
    49            237251             1         -22.9       12.8336
    50            237131             1         -57.4       4.27787
    51            237089         0.141          -150       1.42596
    52            236793             1          -143       1.42596
    53            236117             1          -317      0.475319
    54            235739         0.217          -844       0.15844
    55            235728      0.000588     -8.87e+03       0.15844
    56            235714       0.00104     -6.93e+03       0.15844
    57            234223             1          -618       0.15844
    58            233916         0.363         -72.5     0.0528133
    59            231253         0.362     -2.92e+03     0.0528133
    60            230751         0.111     -2.11e+03     0.0528133
    61            228814             1          -764     0.0528133
    62            227862         0.377          -407     0.0176044
    63            227865        0.0322      5.58e+03     0.0176044
    64            228715         0.488       3.2e+03     0.0352088
    65            227483             1          -153      0.140835
    66            226724         0.998          -305     0.0469451
    67            226390             1          -143     0.0469451
    68            226046             1          -136     0.0156484
    69            225536             1          4.29    0.00521612
    70            225420             1        0.0325    0.00173871
    71            225416         0.301         -4.29   0.000579569
    72            225413             1         0.948   0.000579569
    73            225422         0.376            30   0.000550332
    74            225474         0.669          98.7    0.00110066
    75            225425             1          15.9    0.00440266
    76            225414             1          4.74     0.0352212
    77            225411             1        -0.304       0.28177
    78            225410             1         0.087     0.0939233
    79            225410             1         -0.14     0.0313078
    80            225407             1        -0.956     0.0104359
    81            225430         0.294          86.5    0.00347864
    82            225402             1         0.299    0.00695728
    83            228399         0.824      8.31e+04    0.00231909
    84            228558         0.898      8.69e+04    0.00463819
    85            225560          0.89           400     0.0185528
    86            225383             1          -3.1      0.148422
    87            225383        0.0261        -0.862       0.12367
    88            225741             1           499       0.12367
    89            225630             1           330      0.247339
    90            244660         0.493      1.32e+05      0.989358
    91            225389             1          16.6       7.91486
    92            225380             1         0.517       63.3189
    93            225379             1         0.867       21.1063
    94            225376             1         0.189       14.7246
    95            225374             1        0.0479        4.9082
    96            225374             1          2.04       1.63607
    97            225412         0.247           301       3.27214
    98            225380         0.223          30.4       13.0885
    99            225374             1          1.74       104.708
   100            225374             1         0.708       837.667
   101            225372             1         -0.27       1020.36

 Optimization terminated: Constrained optimum found.
 Parameters converged to within tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0            995927
     1            995381       0.00262     -1.04e+05       2.85551
     2            995182      0.000961     -1.04e+05       2.85551
     3            994903       0.00135     -1.03e+05       2.85551
     4            994719      0.000894     -1.03e+05       2.85551
     5            993892       0.00402     -1.02e+05       2.85551
     6            993524        0.0018     -1.02e+05       2.85551
     7            992611        0.0045     -1.01e+05       2.85551
     8            962793         0.178     -6.87e+04       2.85551
     9            960001        0.0199     -6.82e+04       2.85551
    10            933904         0.265     -3.45e+04       2.85551
    11            922009         0.174     -2.62e+04       2.85551
    12            904628         0.649     -5.05e+03       2.85551
    13            903522         0.041     -1.17e+04       2.85551
    14            896836             1          -991       2.85551
    15            851255         0.975     -2.23e+04       2.86474
    16            749038         0.128       3.2e+06       2.86474
    17            742971       0.00572     -5.27e+05       2.86474
    18            727972        0.0136     -5.46e+05       2.86474
    19            700081        0.0255     -5.18e+05       2.86474
    20             46969             1     -5.07e+04       2.86474
    21           10503.6         0.597     -1.75e+04      0.954914
    22            2026.2             1          -286      0.954914
    23           1893.83         0.789         -27.6      0.318305
    24           1886.32             1        -0.379      0.318305
    25           1885.38         0.977        -0.466      0.106102
    26           1877.98             1         -3.54      0.106102
    27           1877.82       0.00206         -38.1     0.0353672
    28           1844.87             1           9.2     0.0353672
    29           1839.91             1         0.537      0.027604
    30           1839.76          0.45         -0.11    0.00924678
    31           1839.69             1      -0.00382    0.00924678
    32           1839.08             1          1.02    0.00483138
    33           1837.94             1        -0.175    0.00492669
    34           1836.92         0.199         -1.35    0.00164223
    35           1834.36          0.49         -1.79    0.00164223
    36           1833.16             1        -0.102    0.00164223
    37              1833             1       -0.0316    0.00054741
    38           1832.98             1      -0.00479    0.00018247
    39           1832.98             1     -0.000725   6.08234e-05

 Optimization terminated: Constrained optimum found.
 Parameters converged to within tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0        1.0959e+06
     1       1.09589e+06      3.11e-05      -8.9e+04   3.73776e+06
     2       1.09589e+06       1.5e-05     -8.89e+04   3.73776e+06
     3       1.09587e+06      7.84e-05     -8.89e+04   3.73776e+06
     4       1.09584e+06      0.000219     -8.89e+04   3.73776e+06
     5       1.09579e+06       0.00025     -8.84e+04   3.73776e+06
     6       1.04362e+06         0.338     -6.68e+04   3.73776e+06
     7       1.03898e+06        0.0422     -5.42e+04   3.73776e+06
     8       1.03886e+06       0.00813     -6.84e+03   3.73776e+06
     9       1.02574e+06             1     -6.29e+03   3.73776e+06
    10       1.01805e+06         0.259     -1.45e+04   1.24592e+06
    11            993197             1     -1.12e+04   1.24592e+06
    12            959753             1     -1.28e+04        415306
    13            937646             1     -6.55e+03        138435
    14            932336         0.374     -6.61e+03       46145.1
    15            928808         0.327     -5.13e+03       46145.1
    16            927717         0.121     -4.46e+03       46145.1
    17            920315             1     -3.19e+03       46145.1
    18            912272         0.815     -4.13e+03       15381.7
    19            907361             1     -2.02e+03       15381.7
    20            905644         0.267     -3.04e+03       5127.24
    21            901332             1     -1.69e+03       5127.24
    22            896528             1     -1.48e+03       1709.08
    23            894772         0.272     -2.82e+03       805.699
    24            894453        0.0745     -2.08e+03       805.699
    25            891643             1          -908       805.699
    26            890475             1          -193       268.566
    27            890247             1         -18.2       89.5221
    28            890072             1         -22.1       29.8407
    29            889990             1         -13.2       13.4913
    30            889949             1           -13       9.70685
    31            889924         0.195         -55.7       4.76346
    32            889862             1         -14.8       4.76346
    33            889826         0.157          -110       3.62145
    34            889771         0.221          -119       3.62145
    35            889755        0.0447          -179       3.62145
    36            889519         0.595          -196       3.62145
    37            887904             1          -807       3.62145
    38            848808         0.445     -4.29e+04       1.20715
    39            836609       0.00302     -1.73e+06       1.20715
    40            830824       0.00609     -4.64e+05       1.20715
    41            785454        0.0222     -1.01e+06       1.20715
    42            778724       0.00825     -4.07e+05       1.20715
    43            777402      0.000838     -7.89e+05       1.20715
    44            698750        0.0767     -4.96e+05       1.20715
    45            689425       0.00565     -8.02e+05       1.20715
    46            544476         0.154     -4.39e+05       1.20715
    47            355164         0.182     -4.53e+05       1.20715
    48            350853         0.004     -5.35e+05       1.20715
    49            347395       0.00396     -4.35e+05       1.20715
    50            346281        0.0298       8.9e+04       1.20715
    51            331582        0.0199     -3.64e+05       1.20715
    52           13939.3             1     -6.65e+03       1.20715
    53           12412.4         0.185       1.8e+04      0.402383
    54           11014.7         0.154     -3.94e+03      0.402383
    55           8385.94             1           208      0.402383
    56           9668.14             1      2.55e+03      0.134128
    57           8288.89             1          72.3      0.268256
    58           8524.22             1           843      0.140699
    59           10062.2         0.402      1.48e+04      0.281398
    60           8283.43             1           368       1.12559
    61           8057.56             1        -0.298       2.06734
    62           7950.53             1         -46.5      0.689114
    63           7721.56        0.0205     -3.42e+03      0.229705
    64           7592.42        0.0152     -4.05e+03      0.229705
    65           6961.42             1           482      0.229705
    66           6556.29             1            41     0.0765682
    67           6527.01             1         -1.85     0.0255227
    68           8956.97         0.619      1.32e+04    0.00850758
    69           6516.14             1          13.3     0.0170152
    70           6415.78             1         -25.9     0.0167709
    71           6390.65             1         -6.87     0.0055903
    72           4511.92             1          -267    0.00186343
    73           3884.12             1         -34.9      0.001335
    74           3653.32             1         -38.3    0.00111848
    75           3470.23         0.083     -1.04e+03   0.000836694
    76           2320.13             1          -123   0.000836694
    77           2095.11             1         -34.2   0.000278898
    78           1926.19             1          58.6   0.000100024
    79           1917.02         0.275         -13.7   3.33413e-05
    80           1911.54         0.332         -6.46   3.33413e-05
    81           1907.36             1         0.067   3.33413e-05
    82           1905.68             1        -0.107   1.11138e-05
    83            1905.5             1       -0.0348   3.70459e-06
    84            1905.5         0.135       -0.0111   1.23486e-06
    85           1905.49         0.362      -0.00746   1.23486e-06
    86           1905.48             1      -0.00172   1.23486e-06

 Optimization terminated: Constrained optimum found.
 Parameters converged to within tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0            951671
     1            951662      7.52e-05     -6.09e+04       1.24613
     2            951660      1.41e-05     -6.09e+04       1.24613
     3            951654      5.66e-05     -6.09e+04       1.24613
     4            951638      0.000131     -6.09e+04       1.24613
     5            951631      5.68e-05     -6.09e+04       1.24613
     6            951610      0.000169     -6.08e+04       1.24613
     7            949890        0.0144     -5.88e+04       1.24613
     8            944017        0.0526     -5.27e+04       1.24613
     9            943677       0.00319      -5.3e+04       1.24613
    10            931123         0.138     -3.91e+04       1.24613
    11            924148         0.097     -3.17e+04       1.24613
    12            916593         0.134     -2.36e+04       1.24613
    13            910519         0.143     -1.72e+04       1.24613
    14            907342        0.0985     -1.33e+04       1.24613
    15            899867          0.44     -4.71e+03       1.24613
    16            898799        0.0603     -6.99e+03       1.24613
    17            898167        0.0236      -1.2e+04       1.24613
    18            879319         0.658     -1.29e+04       1.24613
    19            772006         0.121     -4.19e+05       1.24613
    20            576709         0.203     -4.27e+05       1.24613
    21            245462          0.78      -7.7e+04       1.24613
    22            221780             1     -1.75e+03       1.24613
    23            193622        0.0698     -1.95e+05      0.415376
    24              2067             1           172      0.415376
    25           1922.97             1         -9.48      0.138459
    26           1919.43             1       -0.0917     0.0461529
    27           1918.04             1         -0.61     0.0153843
    28           1878.56             1        -0.753     0.0051281
    29           1862.07             1         0.887    0.00446959
    30           1859.12             1        -0.572    0.00390671
    31           1858.07        0.0237         -21.9    0.00308025
    32           1856.96        0.0265         -20.7    0.00308025
    33           1838.73             1          3.04    0.00308025
    34           1837.44             1         0.219     0.0014432
    35           1827.09         0.117           -44    0.00105726
    36           1794.17        0.0352          -453    0.00105726
    37           1412.88             1         -1.08    0.00105726
    38           1337.89         0.918         -12.1   0.000352418
    39           1333.53             1        -0.416   0.000352418
    40           1333.46             1      -0.00733   0.000117473
    41           1319.81             1         -4.49   3.91576e-05
    42           1316.92         0.307         -3.84   1.30525e-05
    43           1314.35             1         0.373   1.30525e-05
    44           1314.11             1        -0.002   4.35084e-06
    45           1314.11      0.000888     -0.000426   1.45028e-06
    46           1314.11      0.000892     -0.000371   2.90056e-06
    47           1314.11             1     -4.99e-05   2.90056e-06

 Optimization terminated: Constrained optimum found.
 Norm of gradient less than tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0       1.21819e+06
     1       1.21795e+06      0.000382     -3.09e+05       11.7882
     2       1.21762e+06      0.000531     -3.09e+05       11.7882
     3       1.21754e+06      0.000133     -3.09e+05       11.7882
     4       1.21729e+06      0.000397     -3.09e+05       11.7882
     5       1.21679e+06      0.000822     -3.09e+05       11.7882
     6       1.21644e+06      0.000562     -3.08e+05       11.7882
     7       1.21627e+06      0.000271     -3.08e+05       11.7882
     8       1.21454e+06        0.0028     -3.09e+05       11.7882
     9       1.12997e+06         0.138      -2.8e+05       11.7882
    10            943604         0.569     -8.54e+04       11.7882
    11            926730         0.165     -4.87e+04       11.7882
    12            895567             1      2.06e+04       11.7882
    13            889937             1          -301       7.16513
    14            889851             1         -21.8       2.38838
    15            889792         0.584         -46.8       1.08911
    16            889630         0.566          -143       1.08911
    17            887913             1          -858       1.08911
    18            887532       0.00179     -1.07e+05      0.363036
    19            865275        0.0788      -1.4e+05      0.363036
    20           89455.8             1     -6.41e+04      0.363036
    21           1004.05             1         -7.99      0.121012
    22           998.472         0.886        -0.537     0.0403373
    23           998.397             1      0.000109     0.0403373
    24           998.397        0.0879     -0.000386     0.0134458
    25           998.397             1      7.62e-06     0.0134458

 Optimization terminated: Constrained optimum found.
 Parameters converged to within tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0            994252
     1            994234      8.45e-05     -1.04e+05       3.51621
     2            994211      0.000112     -1.04e+05       3.51621
     3            994201      4.69e-05     -1.04e+05       3.51621
     4            994105      0.000466     -1.03e+05       3.51621
     5            994094      5.38e-05     -1.03e+05       3.51621
     6            964464         0.169      -7.4e+04       3.51621
     7            919449         0.506     -2.62e+04       3.51621
     8            902626         0.495     -9.62e+03       3.51621
     9            900798        0.0818     -9.56e+03       3.51621
    10            893323             1     -1.35e+03       3.51621
    11            892752        0.0395     -6.47e+03       3.44118
    12            885172          0.48      -7.3e+03       3.44118
    13            880433        0.0117     -2.01e+05       3.44118
    14            874026        0.0102     -3.13e+05       3.44118
    15            517977         0.564     -2.34e+05       3.44118
    16            194265          0.43      -2.8e+05       3.44118
    17           3508.23             1          -616       3.44118
    18            2586.4             1           399       1.14706
    19           2318.29          0.59          -126       1.06804
    20           2232.43             1         -8.14       1.06804
    21           2228.84             1        -0.719      0.356012
    22           3775.66         0.501      4.97e+04      0.118671
    23            3789.7         0.514      4.86e+04      0.237342
    24           3871.93         0.584      4.36e+04      0.949366
    25           2896.34         0.868      3.14e+03       7.59493
    26           2006.36             1          87.7       60.7594
    27           1920.35             1            15       43.3436
    28           1863.31             1         -19.4       36.3528
    29           1833.23             1         0.805       15.6437
    30           1813.54             1         -5.21       14.7148
    31           1806.79           0.7         -3.14        8.3088
    32           1801.31             1          -1.8        8.3088
    33           1797.65             1         -1.17       5.20351
    34           1795.02             1        -0.912       3.67372
    35           1792.78             1        -0.825       2.24348
    36           1789.95             1          -1.2       1.34667
    37           1788.66        0.0147         -43.8      0.552441
    38            1735.2             1         -11.8      0.552441
    39           1522.77             1         -71.1       0.29461
    40           3456.77         0.126      4.04e+05      0.114229
    41           3427.64         0.182      2.82e+05      0.228458
    42           3314.26         0.517      1.04e+05      0.913833
    43           1335.87             1         -9.31       7.31067
    44           1636.01             1      4.31e+03       2.43689
    45           1299.82             1         -12.1       4.87378
    46           2742.83         0.478      3.74e+04       1.62459
    47           2724.76         0.797      2.24e+04       3.24918
    48           1285.51             1         -8.35       12.9967
    49           2506.76         0.858      1.32e+04       4.33225
    50           1272.62             1          52.1       8.66449
    51           1230.88             1          -2.6       8.18234
    52           1220.35             1          -1.3       2.72745
    53           1219.57             1        -0.257      0.909149
    54           1218.01             1        -0.772       0.30305
    55           1202.42             1         -7.69      0.101017
    56           1737.41         0.488      2.83e+05     0.0336722
    57            1185.3         0.919           394     0.0673444
    58           1541.85         0.103      4.05e+04     0.0673444
    59           1518.38         0.169      2.38e+04      0.134689
    60           1408.67         0.547      5.91e+03      0.538755
    61            1115.6             1         -8.02       4.31004
    62           1089.45             1          67.4       1.43668
    63           1162.76         0.537           422       1.39967
    64           1137.82         0.981           196       2.79934
    65           1066.71             1         -4.53       11.1973
    66           1107.66         0.951           159       3.73245
    67           1059.75             1          3.34        7.4649
    68           1042.32             1         -6.55       7.17844
    69           1018.31         0.881         -9.49       2.39281
    70           1001.63             1         -4.32       2.39281
    71           998.796             1        -0.609      0.797605
    72            998.57             1       -0.0892      0.265868
    73           998.462             1       -0.0439     0.0886227
    74            998.42             1       -0.0177     0.0295409
    75           998.405             1      -0.00696    0.00984697
    76           998.399         0.463      -0.00637    0.00328232
    77           998.396         0.748      -0.00151    0.00328232
    78           998.396             1      2.26e-08    0.00328232

 Optimization terminated: Constrained optimum found.
 Norm of gradient less than tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0            978580
     1            978249       0.00385     -4.28e+04        263273
     2            972517        0.0691     -4.03e+04        263273
     3            969733        0.0398     -3.44e+04        263273
     4            969688      0.000685     -3.26e+04        263273
     5            965797        0.0612      -3.1e+04        263273
     6            965395       0.00676     -2.96e+04        263273
     7            951243         0.268     -2.35e+04        263273
     8            950248        0.0393     -1.26e+04        263273
     9            950242      0.000214     -1.24e+04        263273
    10            929737             1     -7.94e+03        263273
    11            914901             1     -4.89e+03       87757.5
    12            904127             1     -3.87e+03       29252.5
    13            897504             1     -2.06e+03       9750.84
    14            894392         0.927     -1.17e+03       3250.28
    15            893175             1          -499       3250.28
    16            892183         0.594          -710       1083.43
    17            891791             1          -139       1083.43
    18            891494             1          -112       361.142
    19            891181             1          -121       120.381
    20            890632             1          -238       40.1269
    21            890038             1          -115       13.3756
    22            889938             1         -11.9       4.45854
    23            889933         0.361         -5.12       1.48618
    24            889926             1         -2.34       1.48618
    25            889926        0.0291          -9.4      0.495394
    26            889909             1         -6.78      0.495394
    27            889908       0.00547         -62.4       0.28449
    28            889816          0.81         -55.2       0.28449
    29            889037         0.482          -818       0.28449
    30            823200             1     -3.16e+04       0.28449
    31            823097      0.000143      -3.6e+05       0.09483
    32            807027         0.017     -4.51e+05       0.09483
    33            806494      3.09e-05      -8.6e+06       0.09483
    34            799547       0.00582     -5.95e+05       0.09483
    35            787747       0.00989     -5.92e+05       0.09483
    36            765442        0.0235     -4.68e+05       0.09483
    37            578894          0.18     -4.64e+05       0.09483
    38            564853        0.0186     -3.72e+05       0.09483
    39            546774        0.0246     -2.64e+05       0.09483
    40            520964        0.0306     -4.07e+05       0.09483
    41            515783         0.017     -1.46e+05       0.09483
    42            517502       0.00135      3.95e+06       0.09483
    43            517514       0.00132      4.04e+06       0.18966
    44            517589       0.00117      4.62e+06       0.75864
    45            524319      0.000415      4.47e+08       6.06912
    46            524252      1.52e-05      1.22e+10        48.553
    47            520193       0.00424      4.26e+07       388.424
    48            503198        0.0423      3.59e+06       3107.39
    49            448129        0.0858     -2.49e+05       3107.39
    50            379876             1      2.82e+05       3107.39
    51            333140          0.18     -1.09e+05        1035.8
    52            237489             1      1.06e+03        1035.8
    53            234600             1          -260       345.266
    54            234705         0.991      6.02e+03       115.089
    55            233207             1           404       230.177
    56            232585             1           164       179.319
    57            237496         0.936      1.38e+04       59.7728
    58            236124        0.0504      1.46e+05       119.546
    59            234936             1      5.32e+03       478.183
    60            232409             1         -28.9       3825.46
    61            232318             1         -36.9       1275.15
    62            232315       0.00743          -218       425.051
    63            249194         0.563      1.53e+05       425.051
    64            248618         0.934      8.76e+04       850.103
    65            232315      4.34e-05         -71.7       3400.41
    66            234713             1      2.67e+03       3400.41
    67            232117             1         -78.6       6800.82
    68            229296             1          -934       2266.94
    69            227744             1          -550       1553.05
    70            226485             1          -396       517.685
    71            226095         0.516      1.28e+03       318.392
    72            236441         0.103      3.57e+05       318.392
    73            252670          0.64      1.34e+05       636.785
    74            225749             1         -77.9       2547.14
    75            225654             1         -29.6       849.046
    76            225609             1          4.97       283.015
    77            225625             1          23.9       94.3385
    78            225551             1         -17.6       188.677
    79            225551             1          92.6       79.7577
    80            225520             1         -10.2       159.515
    81            225520      1.41e-05         -8.46       61.9069
    82            226144             1      1.47e+03       61.9069
    83            225693             1           312       123.814
    84            225733          0.48           835       495.255

 Optimization terminated: Constrained optimum found.
 Parameters converged to within tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0       1.13459e+06
     1       1.13459e+06      1.16e-05     -2.37e+05      0.922334
     2       1.13458e+06      1.18e-05     -2.37e+05      0.922334
     3       1.13457e+06       1.6e-05     -2.37e+05      0.922334
     4            991522         0.437     -1.03e+05      0.922334
     5            989353        0.0114     -9.12e+04      0.922334
     6            972360         0.134     -4.19e+04      0.922334
     7            958927         0.208     -1.36e+04      0.922334
     8            940068             1     -3.93e+03      0.922334
     9            453658             1      -6.4e+04       1.06612
    10           42870.7             1     -1.28e+04       0.56127
    11             35067         0.105      -3.4e+04       0.18709
    12           4550.78         0.864          -603       0.18709
    13            3488.1         0.304     -1.26e+03       0.18709
    14           2322.23             1          -128       0.18709
    15           1881.39             1          -117      0.120477
    16           1599.56             1         -15.6     0.0401589
    17           1484.52             1          4.86     0.0133863
    18           1481.53             1          0.36     0.0044621
    19           1481.39             1        0.0355    0.00260014
    20           1481.37             1        0.0045    0.00199752
    21           1478.58       0.00958          -145    0.00169028
    22           1477.93       0.00229          -143    0.00169028
    23           1345.39             1         -5.45    0.00169028
    24           1347.17             1          9.32   0.000652984
    25           1340.41             1          4.09    0.00130597
    26           1338.22         0.119         -8.66    0.00144176
    27           1337.46        0.0506         -7.27    0.00144176
    28           1330.48             1        -0.148    0.00144176
    29           1330.48      0.000499         -1.66   0.000480586
    30           1328.76             1        -0.833   0.000480586
    31           1324.79             1          30.2   0.000160195
    32           1313.55             1        -0.426   0.000175428
    33           1313.52             1     -0.000887   5.84759e-05
    34           1313.52             1     -0.000146    1.9492e-05

 Optimization terminated: Constrained optimum found.
 Norm of gradient less than tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0            988538
     1            988513      0.000567     -2.14e+04   9.10257e+06
     2            963504         0.674     -1.58e+04   9.10257e+06
     3            963187         0.092     -1.72e+03   9.10257e+06
     4            962954         0.068     -1.71e+03   9.10257e+06
     5            962887        0.0197      -1.7e+03   9.10257e+06
     6            962182         0.209     -1.68e+03   9.10257e+06
     7            961090         0.332     -1.63e+03   9.10257e+06
     8            960725         0.114     -1.59e+03   9.10257e+06
     9            958561         0.696     -1.53e+03   9.10257e+06
    10            958292        0.0916     -1.46e+03   9.10257e+06
    11            955511             1     -1.36e+03   9.10257e+06
    12            954453          0.15      -3.5e+03   3.03419e+06
    13            948010             1     -3.01e+03   3.03419e+06
    14            936911             1     -4.64e+03    1.0114e+06
    15            926110             1     -3.78e+03        337132
    16            917817             1     -3.21e+03        112377
    17            907618             1     -4.18e+03       37459.1
    18            907215        0.0348     -5.73e+03       12486.4
    19            905606         0.148     -5.22e+03       12486.4
    20            898500             1     -2.55e+03       12486.4
    21            893944             1     -1.49e+03       4162.13
    22            891519             1          -857       1387.38
    23            891219         0.147          -979       462.458
    24            890587             1          -226       462.458
    25            890198             1          -117       154.153
    26            890063             1         -25.9       51.3843
    27            890008             1         -15.2       17.1281
    28            889980             1         -7.77       6.09154
    29            889962             1         -6.41       2.03051
    30            889942         0.498         -18.9      0.772723
    31            889863             1         -39.5      0.772723
    32            889757        0.0739          -714      0.257574
    33            885220             1     -2.26e+03      0.257574
    34            884371      0.000281     -1.51e+06     0.0858581
    35            862647       0.00326     -3.31e+06     0.0858581
    36            859653      0.000509     -2.92e+06     0.0858581
    37            855590       0.00606     -3.32e+05     0.0858581
    38            849587       0.00537     -3.24e+05     0.0858581
    39            847974       0.00438     -1.77e+05     0.0858581
    40            768726         0.124     -2.81e+05     0.0858581
    41            680854        0.0498     -7.12e+05     0.0858581
    42            633102        0.0607      -2.9e+05     0.0858581
    43            592492        0.0554      1.29e+06     0.0858581
    44            591035       0.00819     -1.42e+05     0.0858581
    45            613987      0.000331      3.05e+12     0.0858581
    46            588239       0.00526      -2.6e+05      0.171716
    47            622309       0.00678      2.56e+07      0.171716
    48            622291        0.0068      2.55e+07      0.343433
    49            613541       0.00039      2.72e+12       1.37373
    50            612946       0.00167      6.41e+11       10.9898
    51            605285         0.018      6.69e+10       87.9187
    52            559188         0.164      1.09e+10        703.35
    53            558675      0.000221     -1.14e+06        703.35
    54            405736         0.292     -1.99e+05        703.35
    55            325963         0.227     -1.61e+04        703.35
    56            285420             1       4.6e+03        703.35
    57            282438             1      1.79e+03        234.45
    58            327999         0.123      1.17e+07         78.15
    59            255131             1          -569         156.3
    60            320207      0.000458      1.19e+11          52.1
    61            320209      0.000507      1.08e+11         104.2
    62            320198      0.000484      1.13e+11         416.8
    63            319229        0.0184      2.95e+09        3334.4
    64            246778             1     -2.46e+03       26675.2
    65            239865             1     -2.19e+03       8891.73
    66            285475         0.129      2.12e+10       2963.91
    67            286947        0.0116      2.35e+11       5927.82
    68            239170             1           297       23711.3
    69            239170      0.000113          -207       8147.31
    70            239116             1           960       8147.31
    71            238027             1         -62.8       8223.64
    72            237145             1          -264       2741.21
    73            236317             1          -127       913.738
    74            236276         0.233           141       304.579
    75            323720         0.832      1.09e+06       304.579
    76            254979         0.336      1.91e+09       609.158
    77            236268             1           100       2436.63
    78            256158         0.532      3.67e+08       3124.61
    79            236268      0.000633         -20.2       6249.23
    80            236236             1         -14.6       6249.23
    81            256307         0.357      4.77e+08       2083.08
    82            256368         0.609      2.81e+08       4166.15
    83            236236        0.0365         -7.15       16664.6
    84            236235      0.000584          -646       16664.6
    85            236228             1         -3.06       16664.6
    86            255855         0.726       1.9e+08       5554.87
    87            236225             1          5.05       11109.7
    88            236223        0.0648         -10.9       6689.46
    89            236198             1          17.2       6689.46
    90            236294         0.403           207       2229.82
    91            256092         0.519      4.91e+08       4459.64
    92            234690             1          -511       17838.6
    93            234195         0.499          -391       10402.6
    94            233690             1          -186       10402.6
    95            258178         0.624      1.17e+09       4863.16
    96            233498             1         -57.8       9726.33
    97            233336             1         -27.7       4421.45
    98            233368         0.547            84       1473.82
    99            257295        0.0334      1.28e+10       2947.63
   100            233772         0.501      1.95e+03       11790.5
   101            233284             1         -18.8       94324.2
   102            233283       0.00464           343       31441.4
   103            233254             1           -13       31441.4
   104            233213         0.646         -27.8       10480.5
   105            233224             1          30.4       10480.5
   106            233207             1          11.3       20960.9
   107            233205             1          34.4       6986.98
   108            258033         0.486      2.91e+08       8630.03
   109            233161             1         -14.1       17260.1
   110            233099             1         -10.4       5753.35
   111            233099      5.55e-05          -500       1917.78
   112            255295        0.0545      3.99e+09       1917.78
   113            233390             1           949       3835.57
   114            233096       0.00658          -225       15342.3
   115            233092      0.000913     -2.35e+03       15342.3
   116            255347        0.0892      2.29e+09       15342.3
   117            233099             1          31.5       30684.5
   118            233040             1         -24.8        122738
   119            232974             1         -31.1       40912.7
   120            232737             1           -81       13637.6
   121            255140         0.189       2.7e+09       4545.86
   122            232525             1         -20.4       9091.71
   123            253908         0.132      1.75e+09       3850.23
   124            232437         0.045          -905       7700.47
   125            232282         0.212          -229       7700.47
   126            232484         0.158      2.82e+03       7700.47
   127            232812         0.294      2.93e+03       15400.9
   128            232234        0.0786          -258       61603.7
   129            231953             1           228       61603.7
   130            231712             1         -44.2       49366.3
   131            231718         0.774          46.7       16455.4
   132            231630         0.108          88.3       32910.9
   133            231516             1         -33.6       32910.9
   134            231050             1          -195       10970.3
   135            231360         0.881           648       3656.77
   136            300536         0.767      7.12e+05       7313.53
   137            231061             1          94.4       29254.1

 Optimization terminated: Constrained optimum found.
 Parameters converged to within tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0       1.01545e+06
     1       1.01544e+06      1.81e-05     -1.23e+05       1.61448
     2       1.01542e+06      7.79e-05     -1.23e+05       1.61448
     3       1.01539e+06       0.00015     -1.23e+05       1.61448
     4       1.01538e+06      1.85e-05     -1.23e+05       1.61448
     5       1.01536e+06      9.93e-05     -1.23e+05       1.61448
     6       1.00895e+06        0.0269     -1.15e+05       1.61448
     7            988544        0.0984     -9.17e+04       1.61448
     8            983769        0.0253     -9.12e+04       1.61448
     9            962876         0.133     -6.64e+04       1.61448
    10            950519        0.0975      -5.5e+04       1.61448
    11            926025         0.305     -2.64e+04       1.61448
    12            906129         0.819     -3.36e+03       1.61448
    13            899012             1     -1.61e+03       1.61448
    14            731383             1     -7.81e+04       1.64476
    15           17565.2             1     -6.82e+03      0.548252
    16           1380.43             1        -1e+03      0.182751
    17           1086.51             1         -12.4     0.0609169
    18           1078.19             1        -0.782     0.0203056
    19           1057.26             1         -9.24    0.00676854
    20           1004.59         0.738         -8.25    0.00225618
    21           998.458             1        -0.138    0.00225618
    22           998.397             1     -0.000288    0.00075206

 Optimization terminated: Constrained optimum found.
 Parameters converged to within tolerance.
Warning: LSQLIN did not converge. Infeasible network contraints.
> In mylsqlin
In multistart
In multistart
In estimate
In inca_script (line 234)

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0       2.22218e+15
     1       2.22218e+15      1.34e-05     -7.83e+04   6.00318e+07

 Optimization terminated: Constrained optimum found.
 Parameters converged to within tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0       1.12022e+06
     1       1.12019e+06      7.73e-05     -2.21e+05       2.49125
     2       1.12015e+06      8.84e-05     -2.21e+05       2.49125
     3       1.12014e+06      2.05e-05     -2.21e+05       2.49125
     4       1.12013e+06      3.23e-05     -2.21e+05       2.49125
     5       1.11992e+06      0.000477     -2.21e+05       2.49125
     6        1.1195e+06      0.000945      -2.2e+05       2.49125
     7       1.11922e+06      0.000638      -2.2e+05       2.49125
     8       1.11902e+06      0.000451      -2.2e+05       2.49125
     9       1.09682e+06        0.0528     -2.01e+05       2.49125
    10       1.05124e+06         0.124     -1.67e+05       2.49125
    11            949081         0.453     -7.53e+04       2.49125
    12            946596        0.0216     -5.66e+04       2.49125
    13            931052         0.156      -4.4e+04       2.49125
    14            906136         0.459     -1.75e+04       2.49125
    15            901947         0.153     -1.17e+04       2.49125
    16            893392          0.64     -3.35e+03       2.49125
    17            890502             1          -465       2.49125
    18            889795             1          -195       1.96117
    19            888960         0.311     -1.29e+03       1.81281
    20            869043             1     -9.81e+03       1.81281
    21            198948             1     -8.57e+04      0.604268
    22           3682.99         0.895     -2.12e+04      0.201423
    23           3245.55        0.0938     -2.22e+03      0.201423
    24           1237.92             1          32.1      0.201423
    25           1220.38             1        -0.688     0.0671409
    26              1220             1       -0.0343     0.0223803
    27           1219.97             1       -0.0122     0.0074601
    28           1219.85             1       -0.0557     0.0024867
    29           1219.49             1       -0.0201     0.0008289

 Optimization terminated: Constrained optimum found.
 Parameters converged to within tolerance.
Warning: LSQLIN did not converge. Infeasible network contraints.
> In mylsqlin
In multistart
In multistart
In estimate
In inca_script (line 234)

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0        1.6244e+15
     1        1.6243e+15         0.152     -3.53e+11      0.482762
     2       1.62426e+15      1.01e-05     -1.58e+15      0.482762
     3       1.59418e+15        0.0291     -5.09e+14      0.482762
     4       1.09968e+15             1      2.53e+04      0.482762
     5       1.09968e+15        0.0134     -3.62e+04      0.160921
     6       1.09968e+15         0.762     -3.46e+03      0.160921
     7       1.09968e+15             1      -0.00569      0.160921
     8       1.09968e+15          0.33     -4.48e-05     0.0536402
     9       1.09968e+15             1     -4.47e-05     0.0536402
    10       1.09968e+15             1     -2.24e-05       0.10728
    11       1.09968e+15             1     -3.52e+03      0.429122
    12       1.09968e+15             1     -0.000701      0.167477
    13       1.09958e+15      8.27e-05     -5.87e+14     0.0558256
    14        1.0974e+15      0.000992      -1.1e+15     0.0558256
    15       7.52543e+14         0.172     -9.09e+14     0.0558256
    16       6.35175e+14        0.0813     -6.91e+14     0.0558256
    17       6.35175e+14             1       -0.0795     0.0558256
    18       6.35175e+14             1     -2.61e+03     0.0186085
    19       6.35175e+14        0.0427     -7.13e+03    0.00620284
    20       6.35175e+14         0.752     -2.92e+03    0.00620284
    21       6.35175e+14             1     -9.41e-05    0.00620284
    22       6.35175e+14             1       -0.0368    0.00206761
    23       6.35175e+14         0.734     -6.23e+03   0.000689205
    24       6.35175e+14         0.395     -1.35e+03   0.000689205
    25       6.35175e+14             1     -2.89e-06   0.000689205
    26       6.35175e+14             1         -56.8   0.000229735
    27       6.35175e+14             1        -0.236   7.65783e-05
    28       6.35175e+14         0.668     -1.08e+03   2.55261e-05
    29       6.35175e+14         0.162         -40.9   2.55261e-05
    30       6.35175e+14             1          1.46   2.55261e-05
    31       5.38842e+14        0.0789     -5.85e+14    8.5087e-06
    32       5.38842e+14             1           1.7    8.5087e-06
    33       5.38842e+14             1          -333   4.99758e-06
    34       5.38842e+14      3.08e-05     -1.01e+03    4.2577e-06
    35       5.38842e+14         0.698          -144    4.2577e-06
    36       5.38842e+14             1           0.7    4.2577e-06
    37       5.38842e+14             1         0.388   1.41923e-06
    38       5.38842e+14             1         -42.8   4.73078e-07
    39       5.38842e+14         0.322         -25.2   2.77786e-07
    40       5.38842e+14             1        0.0709   2.77786e-07
    41       5.38842e+14             1         -11.7   9.25952e-08
    42       5.38842e+14        0.0508          -100   4.46776e-08
    43       5.38842e+14             1         -3.11   4.46776e-08
    44       5.38842e+14             1        -0.164   1.48925e-08
    45       5.38842e+14             1       -0.0177   4.96418e-09
    46       5.38842e+14             1      -0.00467   1.65473e-09
    47       5.38842e+14             1        0.0123   5.51576e-10
    48       5.38842e+14          0.14     -1.57e+04   1.10315e-09
    49       5.38842e+14          0.15     -3.61e+03   1.10315e-09
    50       5.38842e+14             1         -4.04   1.10315e-09
    51       5.38842e+14             1       -0.0221   3.67717e-10
    52       5.38842e+14         0.175       -0.0275   1.22572e-10
    53       5.38842e+14             1     -0.000154   1.22572e-10
    54       5.38842e+14             1     -9.34e-05   2.45145e-10
    55       4.11031e+14         0.127     -4.71e+14   9.80579e-10
    56       3.95887e+14        0.0186      1.23e+17   9.80579e-10
    57       3.95884e+14      0.000286     -5.02e+12   9.80579e-10
    58       3.95884e+14             1         -4.53   9.80579e-10
    59       3.95884e+14             1          26.1    3.2686e-10
    60       3.95884e+14         0.642           -30   3.11472e-10
    61       3.95884e+14             1         0.722   3.11472e-10
    62       3.95884e+14             1          -238   1.03824e-10
    63       3.95884e+14             1         -62.3   9.42224e-11
    64       3.95884e+14         0.222         -48.5   7.62809e-11
    65       3.95884e+14             1          1.02   7.62809e-11
    66       3.95884e+14             1          2.81   7.54036e-11
    67       3.95884e+14             1          1.33   2.51345e-11
    68       3.95884e+14             1          1.33   5.02691e-11

 Optimization terminated: Constrained optimum found.
 Parameters converged to within tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0            938598
     1            938577      0.000212     -4.87e+04       3.49017
     2            938573      4.34e-05     -4.87e+04       3.49017
     3            938571      2.32e-05     -4.87e+04       3.49017
     4            938564       6.5e-05     -4.87e+04       3.49017
     5            938563      1.46e-05     -4.87e+04       3.49017
     6            938553      0.000102     -4.87e+04       3.49017
     7            938504      0.000503     -4.86e+04       3.49017
     8            937690       0.00846     -4.77e+04       3.49017
     9            936073        0.0172     -4.59e+04       3.49017
    10            935807       0.00288      -4.6e+04       3.49017
    11            920449         0.205     -3.04e+04       3.49017
    12            903763          0.39     -1.43e+04       3.49017
    13            896230          0.44     -5.12e+03       3.49017
    14            895348        0.0774     -4.99e+03       3.49017
    15            891687             1          -187       3.49017
    16            891668       0.00252      -3.8e+03       3.44795
    17            888294         0.838     -1.68e+03       3.44795
    18            887385        0.0107     -4.25e+04       3.44795
    19            771347             1     -5.26e+04       3.44795
    20            664523         0.129      -3.9e+05       1.14932
    21            457719         0.277      6.19e+09       1.14932
    22            438472        0.0442     -2.13e+05       1.14932
    23            363666         0.199     -1.67e+05       1.14932
    24            338591         0.129      -7.6e+04       1.14932
    25            329392        0.0479     -5.75e+04       1.14932
    26            314520        0.0843     -7.45e+04       1.14932
    27            236114             1      7.65e+03       1.14932
    28            280949         0.216      2.21e+06      0.383106
    29            281560         0.164      3.01e+06      0.766211
    30            365330             1      1.11e+06       3.06485
    31            376275         0.887       1.5e+06       24.5188
    32            233129         0.425     -2.61e+03        196.15
    33            234259             1      1.24e+03        196.15
    34            234590             1      1.55e+03         392.3
    35            235181             1      4.18e+03        1569.2
    36            229506             1          -997       12553.6
    37            228713             1          -297       4184.54
    38            228099             1          -149       1394.85
    39            227171             1          -378       464.948
    40            227157        0.0423          -156       154.983
    41            227108          0.21          -104       154.983
    42            227060             1           141       154.983
    43            226953        0.0769           407       153.728
    44            227314             1           577       153.728
    45            227252             1           625       307.456
    46            227802         0.906      1.91e+03       1229.82
    47            226851             1         -28.1       9838.59
    48            226702             1         -55.4       3279.53
    49            226583             1         -49.6       1093.18
    50            226537             1          12.3       364.392
    51            226525        0.0355          -146       121.464
    52            226445             1         -23.8       121.464
    53            230314             1      3.36e+03        40.488
    54            227952             1      2.86e+03        80.976
    55            226477             1           328       323.904
    56            226389             1         -19.4       2591.23
    57            226425             1          92.4       863.744
    58            226347             1         -16.4       1727.49
    59            226707             1           580        575.83
    60            226272             1           -35       1151.66
    61            226276             1          64.7       383.886
    62            226224             1         -18.5       767.773
    63            226224        0.0141         -2.52       255.924
    64            226210             1          13.4       255.924
    65            226167         0.406         -30.7       85.3081
    66            226147             1          3.79       85.3081
    67            226098             1           -10        28.436
    68            226126         0.853            44       14.1124
    69            226085        0.0269          -223       28.2247
    70            226054         0.348           -43       28.2247
    71            226003         0.409         -51.3       28.2247
    72            227723          0.25      1.57e+04       28.2247
    73            226440             1           417       56.4495
    74            226022             1            48       225.798
    75            225915             1         -25.3       1806.38
    76            231821             1      1.36e+04       602.128
    77            225949             1          96.6       1204.26
    78            225933             1          51.6       4817.02

 Optimization terminated: Constrained optimum found.
 Parameters converged to within tolerance.

                                         Directional
 Iteration      Residual     Step-size    derivative        Lambda
     0            998.37
     1            997.99      0.000191          -998   1.38939e-09
     2           987.275       0.00539          -992   1.38939e-09
     3           938.632         0.025          -960   1.38939e-09
     4           938.377      0.000136          -938   1.38939e-09
     5           911.937        0.0142          -923   1.38939e-09
     6           819.411        0.0523          -859   1.38939e-09
     7            344.67         0.358          -514   1.38939e-09
     8           4.15936             1         -4.22   1.38939e-09
     9           1.39752             1       -0.0684    4.6313e-10

 Optimization terminated: Constrained optimum found.
 Parameters converged to within tolerance.

        Estimation completed in 184.5100 seconds.

        Preprocessing time:     15.6900 s

        Computation time:       168.1100 s

        Postprocessing time:    0.7100 s


 ========== Varying ex_1 upward from 100 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.621701       0.17621       0.17621     -0.000031      1.389963      7          0            1   1.66351e-09
     2          0.146581      0.252722     0.0765122     -0.000009      0.000000      0          0            1   5.54504e-10
     3          0.914867      0.311519     0.0587967     -0.000006      0.000000      0          0            1   1.84835e-10
     4          1.683153      0.361117     0.0495977     -0.000005      0.000000      0          0            1   6.16115e-11
     5          2.451440      0.404828     0.0437109     -0.000005      0.000000      0          0            1   2.05372e-11
     6          3.219728      0.444354     0.0395261     -0.000004      0.000000      0          0            1   6.84573e-12
     7          3.310552      0.448802     0.0044477     -0.000000      0.000000      0          0        0.122   2.28191e-12
     8          4.078840      0.484828     0.0360268     -0.000004      0.000000      0          0            1   2.28191e-12

 ========== Varying ex_1 downward from 100 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.666994       0.19032       0.19032      0.000724      1.436008      4          0            1   1.66351e-09
     2          0.101308      0.268273     0.0779528      0.000009      0.000000      0          0            1   5.54504e-10
     3          0.869599      0.327637     0.0593642     -0.000001      0.000000      0          0            1   1.84835e-10
     4          1.637890      0.377534     0.0498971     -0.000000      0.000000      0          0            1   6.16115e-11
     5          2.406184      0.421423     0.0438893      0.000002      0.000000      0          0            1   2.05372e-11
     6          3.174475      0.461062     0.0396387     -0.000001      0.000000      0          0            1   6.84573e-12
     7          3.942766      0.497488     0.0364262     -0.000001      0.000000      0          0            1   2.28191e-12

 ========== Varying R1 upward from 127 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.673055       0.24177       0.24177      0.000630      1.441976      5          0            1   1.66351e-09
     2          0.095229      0.341117     0.0993475     -0.000007      0.000000      0          0            1   5.54504e-10
     3          0.863515      0.416681     0.0755635     -0.000005      0.000000      0          0            1   1.84835e-10
     4          1.631803      0.480163     0.0634826     -0.000005      0.000000      0          0            1   6.16115e-11
     5          2.400090      0.535988     0.0558247     -0.000004      0.000000      0          0            1   2.05372e-11
     6          3.168358      0.586398     0.0504103      0.000102      0.000127      1          0            1   6.84573e-12
     7          3.936645      0.632718     0.0463198     -0.000004      0.000000      0          0            1   2.28191e-12

 ========== Varying R1 downward from 127 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.620714      0.223165      0.223165      0.000035      1.389041      5          0            1   1.66351e-09
     2          0.147574       0.32033     0.0971651     -0.000003      0.000000      0          0            1   5.54504e-10
     3          0.345730      0.341099     0.0207693     -0.000000      0.000000      0          0        0.278   1.84835e-10
     4          1.114020      0.412153     0.0710534     -0.000002      0.000000      0          0            1   1.84835e-10
     5          1.882310      0.472939     0.0607863     -0.000002      0.000000      0          0            1   6.16115e-11
     6          2.650600      0.526933     0.0539939     -0.000002      0.000000      0          0            1   2.05372e-11
     7          3.418890      0.576003     0.0490704     -0.000002      0.000000      0          0            1   6.84573e-12
     8          4.187181      0.621293     0.0452895     -0.000001      0.000000      0          0            1   2.28191e-12

 ========== Varying R2 exch upward from 1e-07 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.000000   2.08522e+06   2.08522e+06     -0.000000      0.000000      0          0            1   1.66351e-09
     2         -0.078657   2.08522e+06        3.3144     -0.000286      0.846663      7          0            1   5.54504e-10
     3          0.546078   2.08522e+06       1.40158      0.000903      0.000248      1          0        0.829   1.84835e-10
     4          1.316682   2.08523e+06       1.42286      0.002571      0.000259      1          0            1   1.84835e-10
     5          1.493013   2.08523e+06      0.291599      0.000107      0.000006      1          0        0.242   6.16115e-11
     6          1.873573   2.08523e+06      0.596743      0.000487      0.000035      1          0        0.511   6.16115e-11
     7          2.643608   2.08523e+06       1.09806      0.006470      0.004727      1          0            1   6.16115e-11
     8          3.413459   2.08523e+06      0.986595      0.001695      0.000136      1          0            1   2.05372e-11
     9          4.106685   2.08523e+06      0.816031      0.001250      0.000096      1          0        0.904   6.84573e-12

 ========== Varying R2 exch downward from 1e-07 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda

 ========== Varying R5 net upward from -38.92 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.022292       4.75207       4.75207      0.070183      1.128583      6          0        0.292   1.66351e-09
     2         -0.553583       10.6581       5.90603      0.053402      0.055293      1          0        0.676   1.66351e-09
     3         -0.408886       12.1026       1.44447      0.000135      0.000263      2          0        0.217   1.66351e-09
     4          0.336462       18.0289       5.92632     -0.005327      0.017618      1          0            1   1.66351e-09
     5          0.443787       18.7553      0.726394     -0.000312      0.000133      1          0        0.155   5.54504e-10
     6          1.193820        23.333       4.57773     -0.012373      0.005885      1          0            1   5.54504e-10
     7          1.946928       27.3724       4.03944     -0.012523      0.002660      1          0            1   1.84835e-10
     8          2.701028       31.0718       3.69938     -0.011893      0.002300      1          0            1   6.16115e-11
     9          2.778660       31.4387      0.366843     -0.000125      0.000075      1          0        0.106   2.05372e-11
    10          3.533108       34.8841       3.44545     -0.011432      0.002412      1          0            1   2.05372e-11
    11          4.289103       38.1739       3.28977     -0.011087      0.001209      1          0            1   6.84573e-12

 ========== Varying R5 net downward from -38.92 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.387131       5.23636       5.23636      0.078800      1.342600      5          0        0.219   1.66351e-09
     2         -1.397515       7.19761       1.96125      0.002252      0.002284      4          0        0.103   1.66351e-09
     3         -1.318205       12.6463       5.44873      0.059268      0.264639      2         12            1       14.2895
     4         -1.033456       18.9168       6.27045      0.272451      0.410755      2          0            1       4.76315
     5         -0.625061       24.2137       5.29693      0.420932      0.522917      3          1            1       3.17543
     6         -0.190222       28.2968       4.08311      0.331752      0.453271      4          0            1       2.56977
     7         -0.131510       28.7465      0.449714      0.000306      0.003795      1          0        0.145       1.73257
     8          0.328460       31.7117       2.96519      0.104881      0.287510     15          0            1       1.73257
     9          0.939105       34.0663       2.35455     -0.009549      0.121325     27          0            1      0.577522
    10          1.688598       35.6653       1.59901     -0.010890      0.004841     10          0            1      0.192507
    11          2.446747       36.8907       1.22536     -0.007427      0.001881      7          0            1     0.0641691
    12          3.208355       37.9284       1.03774     -0.005935      0.000542      3          0            1     0.0213897
    13          3.971234       38.8485      0.920068     -0.005077      0.000285      1          0            1     0.0071299

 ========== Varying R5 exch upward from 2.533 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1          0.000001        609174        609174      0.000000      0.000000      0          0            1   1.66351e-09
     2          0.000008   4.07531e+06   3.46613e+06     -0.000000      0.000000      0          0            1   5.54504e-10
     3         -1.397515   4.07531e+06       4.82899      0.074976      1.592747      9          0         0.34   1.84835e-10
     4         -1.397515   4.07532e+06       6.51948     -0.017444      0.366033      3         13            1       12.7017
     5         -1.397515   4.09776e+06       22443.7     -0.000000      0.000000      0          0            1       4.23391
     6         -1.397515   4.13663e+06       38873.8      0.000000      0.000000      0          0            1        1.4113
     7         -1.397515   4.20397e+06       67332.1     -0.000000      0.000000      0          0            1      0.470435
     8         -1.397515   4.32055e+06        116581     -0.000000      0.000000      0          0            1      0.156812
     9         -1.397515   4.52277e+06        202226     -0.000000      0.000000      0          0            1     0.0522705
    10         -1.397515    4.8732e+06        350422      0.000000      0.000000      0          0            1     0.0174235
    11         -1.397515   5.47759e+06        604397     -0.000000      0.000000      0          0            1    0.00580784
    12         -1.397515    6.5375e+06   1.05991e+06      0.000000      0.000000      0          0            1    0.00193595
    13         -1.397515   8.42812e+06   1.89062e+06      0.000000      0.000000      0          0            1   0.000645315
    14         -1.397515   9.99995e+06   1.57183e+06      0.000000      0.000000      0          0        0.428   0.000215105
    15         -1.221966   9.99996e+06       7.56443      0.076503      0.282297      2          6            1       7.04856
    16         -0.671789   9.99997e+06       7.75599      0.094640      0.145455      2          0            1       2.34952
    17         -0.184116   9.99997e+06       5.98467     -0.002680      0.249468      3          0            1      0.783174
    18          0.555968   9.99998e+06       5.38756     -0.011423      0.009714      1          0            1      0.261058
    19          1.305777   9.99998e+06       4.47808     -0.012924      0.004068      1          0            1     0.0870193
    20          2.058453   9.99999e+06       3.97801     -0.012542      0.002713      1          0            1     0.0290064
    21          2.812642   9.99999e+06       3.66182     -0.012006      0.002003      1          0            1    0.00966881
    22          3.567767   9.99999e+06       3.44269     -0.011501      0.001640      1          0            1    0.00322294
    23          4.323599         1e+07       3.28255     -0.011059      0.001394      1          0            1    0.00107431

 ========== Varying R5 exch downward from 2.533 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1          0.000000        2.5335        2.5335      0.000000      0.000000      0          0     4.19e-06   1.66351e-09

 ========== Varying R7 net upward from 25.1 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.006549       4.24338       4.24338      0.260197      1.034758      9          0            1   1.66351e-09
     2          0.764729       5.73193       1.48856      0.004751      0.001765      2          0            1   1.66351e-09
     3          1.535671       6.95508       1.22315      0.003412      0.000761      1          0            1   5.54504e-10
     4          2.306389       8.01478        1.0597      0.002886      0.000460      1          0            1   1.84835e-10
     5          3.076931       8.96071      0.945936      0.002590      0.000339      2          0            1   6.16115e-11
     6          3.847322       9.82156      0.860846      0.002382      0.000282      1          0            1   2.05372e-11

 ========== Varying R7 net downward from 25.1 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.395476       1.65294       1.65294      0.016585      1.304616      3          0        0.224   1.66351e-09
     2         -0.634127       6.55927       4.90634      0.513958      0.520901      2          0            1   1.66351e-09
     3          0.132850       8.51121       1.95194      0.030651      0.031966      3          0            1    1.7277e-09
     4          0.876034       10.0118       1.50062      0.013458      0.038566      8          0            1   5.75901e-10
     5          1.643215       11.2922       1.28032      0.008740      0.009851      5          0            1   1.91967e-10
     6          1.687452       11.3609     0.0687386      0.000003      0.000000      0          0       0.0608   6.39891e-11
     7          2.454584       12.4843       1.12336      0.006041      0.007200     13          0            1   6.39891e-11
     8          3.221788       13.5041       1.01988      0.004359      0.005447     17          0            1   2.13297e-11
     9          3.988120       14.4448      0.940694      0.003294      0.005255     12          0            1   7.10989e-12

 ========== Varying R7 exch upward from 85.5 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.394463       2.26191       2.26191      0.005190      1.359424      7          0        0.142   1.66351e-09
     2         -0.676403       13.0118       10.7499     -0.022861      0.027370      4          0            1   1.66351e-09
     3         -0.419337       14.8273       1.81556     -0.001063      0.017717      4          0        0.402   5.54504e-10
     4          0.293799       18.9355        4.1082     -0.006455      0.048700      2          0            1   5.54504e-10
     5          0.361297        19.261      0.325482     -0.000044      0.000008      1          0       0.0961   1.84835e-10
     6          1.123506        22.596       3.33499     -0.005300      0.000783      1          0            1   1.84835e-10
     7          1.886486       25.4929       2.89687     -0.004690      0.000622      1          0            1   6.16115e-11
     8          2.003837       25.9101      0.417271     -0.000102      0.000015      1          0         0.16   2.05372e-11
     9          2.767262       28.4816       2.57142     -0.004255      0.000612      1          0            1   2.05372e-11
    10          3.377546        30.391       1.90939     -0.002547      0.000306      1          0        0.805   6.84573e-12
    11          3.589754       31.0298      0.638807     -0.000296      0.000036      1          0        0.284   6.84573e-12
    12          4.353753       33.2387       2.20897     -0.003766      0.000527      1          0            1   6.84573e-12

 ========== Varying R7 exch downward from 85.5 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.121075        9.7481        9.7481      0.048287      0.937653      7          0            1   1.66351e-09
     2          0.652695       13.0211       3.27304      0.006009      0.000530      1          0            1   5.54504e-10
     3          1.425128       15.6807       2.65953      0.017493      0.013352      1          0            1   1.84835e-10
     4          2.196808       17.9719       2.29126      0.003794      0.000405      1          0            1   6.16115e-11
     5          2.968014       20.0107       2.03881      0.003284      0.000370      1          0            1   2.05372e-11
     6          3.738876       21.8627       1.85192      0.002919      0.000349      1          0            1   6.84573e-12
     7          3.861133       22.1422      0.279561      0.000067      0.000008      1          0        0.164   2.28191e-12

 ========== Varying R9 net upward from -15.8 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.359109       3.90527       3.90527      0.019042      1.342971      6          0        0.176   1.66351e-09
     2         -1.343085       4.48527      0.579993      0.007769      0.007756      1          0       0.0531   1.66351e-09
     3         -1.322961       5.00317      0.517908      0.000026      0.000012      1          0       0.0879   1.66351e-09
     4         -0.543289       10.4529       5.44976      0.143094      0.131713      1          0            1   1.66351e-09
     5         -0.208305       11.7262       1.27325      0.001004      0.000517      1          0        0.477   1.25248e-09
     6          0.562066       14.0671       2.34095      0.005572      0.003492      1          0            1   1.25248e-09
     7          1.331628       15.9574       1.89027      0.003064      0.001794      2          0            1   4.17495e-10
     8          2.100872       17.5852       1.62778      0.002090      0.001138      1          0            1   1.39165e-10
     9          2.363287       18.0971      0.511968      0.000153      0.000099      1          0        0.353   4.63883e-11
    10          2.414153       18.1942      0.097069      0.000005      0.000000      0          0       0.0692   4.63883e-11
    11          3.182959       19.5872       1.39295      0.001462      0.000948      1          0            1   4.63883e-11
    12          3.391249       19.9434      0.356191      0.000073      0.000064      1          0        0.279   1.54628e-11
    13          4.159926       21.1932       1.24989      0.001138      0.000752      1          0            1   1.54628e-11

 ========== Varying R9 net downward from -15.8 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.264626       2.40079       2.40079     -0.000832      1.292165      4          0        0.145   1.66351e-09
     2         -0.503011       7.62635       5.22555      0.137570      0.144247      2          0            1   1.66351e-09
     3          0.261826       10.7371       3.11072      0.025263      0.028717      1          0            1   1.22358e-09
     4          0.363301       11.0916      0.354574     -0.000020      0.000053      1          0        0.144   4.07859e-10
     5          1.128340       13.4973       2.40566      0.011018      0.014271      2          0            1   4.07859e-10
     6          1.203817       13.7142      0.216927     -0.000009      0.000000      0          0        0.104   1.35953e-10
     7          1.968199       15.7653       2.05109      0.007424      0.011333      5          0            1   1.35953e-10
     8          2.733795       17.6103       1.84501      0.004684      0.007380      7          0            1   4.53177e-11
     9          3.148259       18.5433      0.932978      0.000731      0.001465      3          0        0.551   1.51059e-11
    10          3.913458       20.1695       1.62615      0.002923      0.006016     13          0            1   1.51059e-11

 ========== Varying R9 exch upward from 101 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.919050       5.42262       5.42262      0.003871      1.019966      7          0        0.234   1.66351e-09
     2         -0.827429       6.75877       1.33615     -0.000379      0.000025      1          0         0.15   1.66351e-09
     3         -0.084968       15.2104       8.45164     -0.018579      0.007252      2          0            1   1.66351e-09
     4          0.664877       21.7709       6.56047     -0.016249      0.002198      1          0            1   5.54504e-10
     5          0.937148       23.9021        2.1312     -0.001888      0.000102      1          0        0.376   1.84835e-10
     6          1.183394        25.743        1.8409     -0.001605      0.000044      1          0         0.34   1.84835e-10
     7          1.936869       30.9656       5.22258     -0.014327      0.000490      1          0            1   1.84835e-10
     8          2.107003       32.0769       1.11139     -0.000643      0.000028      1          0        0.232   6.16115e-11
     9          2.168458       32.4733       0.39631     -0.000082      0.000003      1          0       0.0842   6.16115e-11
    10          2.923945       37.1538       4.68059     -0.012358      0.000447      1          0            1   6.16115e-11
    11          3.407510        39.995       2.84118     -0.004631      0.000192      1          0        0.646   2.05372e-11
    12          4.164486       44.2549       4.25986     -0.010858      0.000459      1          0            1   2.05372e-11

 ========== Varying R9 exch downward from 101 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.070555       18.9029       18.9029      0.287262      1.778649      5         11        0.922       1.78618
     2         -0.399588       26.5528       7.64996      0.037495      0.090330     17          0            1       1.78618
     3         -0.315619       27.3168      0.763969      0.000242      0.002755      2          0        0.135      0.595394
     4          0.372729       32.8416       5.52477      0.036797      0.094777     16          0            1      0.595394
     5          1.063047       37.8827       5.04111      0.150553      0.209304     20          0            1      0.198465
     6          1.789454       42.5017       4.61907      0.034775      0.064468     34          0            1      0.141892
     7          2.575967       46.2684       3.76665      0.022081      0.002690      8          0            1     0.0472975
     8          3.353981       49.2706       3.00225      0.017213      0.007199      6          0            1     0.0157658
     9          4.135927       51.8037       2.53306      0.014415      0.000681      1          0            1    0.00525528

 ========== Varying R11 net upward from 101.9 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.882646       3.87262       3.87262      0.009271      0.748970      4          0        0.156   1.66351e-09
     2         -0.209019       9.18281       5.31019      0.036124      0.042222      1          0        0.905   1.66351e-09
     3         -0.170155       9.43537      0.252565     -0.000008      0.000000      0          0       0.0574   1.66351e-09
     4         -0.117450       9.76379      0.328411      0.000110      0.000110      1          0       0.0888   1.66351e-09
     5          0.011060       10.4946      0.730849      0.000975      0.000792      1          0        0.205   1.66351e-09
     6          0.786171       13.7899       3.29524      0.335676      0.328856      2          1            1   3.32702e-09
     7          0.852465       14.0203      0.230442      0.000185      0.000305      1          0        0.096   3.32034e-09
     8          1.626218       16.3735       2.35314      0.227393      0.221933      1          0            1   3.32034e-09
     9          1.741997       16.6854        0.3119      0.000371      0.000268      1          0        0.161   3.09474e-09
    10          2.515072       18.5817       1.89637      0.205941      0.201157      2          0            1   3.09474e-09
    11          2.620769       18.8201      0.238377      0.000259      0.000198      1          0        0.144   2.78578e-09
    12          2.669014       18.9275      0.107394      0.000033      0.000014      1          0       0.0661   2.78578e-09
    13          3.441487       20.5403       1.61284      0.210864      0.206683      3          0            1   2.78578e-09
    14          3.531785       20.7173      0.176985      0.000162      0.000100      1          0        0.122   2.53009e-09
    15          3.642327       20.9311      0.213754      0.000285      0.000197      1          0        0.149   2.53009e-09
    16          4.414333       22.3443       1.41324      0.235631      0.231917      3          0            1   2.53009e-09

 ========== Varying R11 net downward from 101.9 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.273515       11.7177       11.7177      0.004224      1.294123      8          0        0.136   1.66351e-09
     2         -0.511033         15.95        4.2323      0.089088      0.094897      1          0            1   1.66351e-09
     3         -0.035119       17.5821       1.63214      0.001346      0.002399      1          0        0.656   9.09704e-10
     4          0.731049        19.701       2.11892      0.000781      0.002905      1          0            1   9.09704e-10
     5          1.497670       21.4704       1.76937     -0.000381      0.001289      1          0            1   3.03235e-10
     6          1.626116       21.7434      0.272937     -0.000033      0.000008      1          0        0.176   1.01078e-10
     7          2.393048       23.2674       1.52402     -0.000647      0.000712      1          0            1   1.01078e-10
     8          3.160146       24.6479       1.38055     -0.000665      0.000529      1          0            1   3.36927e-11
     9          3.927373       25.9199         1.272     -0.000636      0.000429      1          0            1   1.12309e-11

 ========== Varying R11 exch upward from 56.75 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.059445       4.05375       4.05375      0.005066      1.129650      4          0        0.205   1.66351e-09
     2         -0.308983       9.98224       5.92849      0.049669      0.067499      2          0            1   1.66351e-09
     3          0.448692       14.1552         4.173     -0.002004      0.008612      1          0            1   5.65426e-10
     4          1.208848       17.6123       3.45705     -0.005153      0.002983      1          0            1   1.88475e-10
     5          1.970344       20.6511       3.03885     -0.005650      0.001146      1          0            1   6.28251e-11
     6          2.732716       23.4072       2.75601     -0.005275      0.000645      1          0            1   2.09417e-11
     7          3.104597       24.6723       1.26515     -0.001231      0.000126      1          0        0.496   6.98056e-12
     8          3.867475       27.1391       2.46679     -0.004775      0.000638      1          0            1   6.98056e-12

 ========== Varying R11 exch downward from 56.75 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.307741       6.49202       6.49202      0.192621      1.525612      3          0        0.476   1.66351e-09
     2         -0.679582       12.5308        6.0388      0.165323      0.193040      3         11            1       1.78618
     3         -0.301640       14.6884       2.15762      0.019293      0.021380      3          0        0.562      0.641034
     4          0.323651       17.5239       2.83547      0.055729      0.062019      2          0        0.869      0.641034
     5          1.049935       20.2028       2.67888      0.043865      0.062839     16          0            1      0.641034
     6          1.785299        22.518       2.31519      0.038563      0.058070     28          0            1      0.213678
     7          2.541794       24.5538       2.03582      0.005586      0.014897     26          0            1      0.071226
     8          3.287110       26.2883       1.73449      0.003178      0.025899     14          0            1      0.023742
     9          3.744634       27.2495       0.96118     -0.000216      0.000448      3          0        0.611      0.007914
    10          4.512954       28.7196       1.47008      0.001698      0.001617      3          0            1      0.007914

 ========== Varying R13 net upward from -46.26 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.397515       8.71344       8.71344      0.004372      1.397574      8          0        0.125   1.66351e-09
     2         -1.396659       16.4318        7.7184      0.200919      0.968354      7          0            1   1.66351e-09
     3         -0.638430        23.503       7.07119      0.116221      0.126284      1          0            1     1.483e-09
     4          0.126308       26.5879       3.08491      0.014088      0.017641      2          0            1   9.79858e-10
     5          0.892029       28.9697       2.38178      0.006473      0.009044      1          0            1   3.26619e-10
     6          1.070127        29.465       0.49531     -0.000054      0.000079      1          0        0.245   1.08873e-10
     7          1.485993       30.5583       1.09329      0.000152      0.000801      1          0        0.559   1.08873e-10
     8          2.252185         32.39       1.83165      0.004598      0.006698      2          0            1   1.08873e-10
     9          3.018527       34.0454       1.65542      0.004511      0.006460      1          0            1    3.6291e-11
    10          3.784960        35.569       1.52366      0.004910      0.006768      1          0            1    1.2097e-11
    11          4.551490       36.9894       1.42035      0.005299      0.007061      1          0            1   4.03234e-12

 ========== Varying R13 net downward from -46.26 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.604757       3.25251       3.25251      0.014731      0.496527      6          0        0.147   1.66351e-09
     2         -0.149345       7.62964       4.37713      0.000230      0.313110      4          0            1   1.66351e-09
     3          0.610139       10.4561       2.82643     -0.006798      0.002010      1          0            1   5.54504e-10
     4          0.652120        10.582      0.125911     -0.000017      0.000001      1          0       0.0618   1.84835e-10
     5          0.864130       11.1892      0.607197     -0.000420      0.000019      1          0        0.302   1.84835e-10
     6          0.905118       11.3016      0.112439     -0.000015      0.000000      3          0       0.0592   1.84835e-10
     7          1.259545       12.2191      0.917455     -0.001046      0.000067      1          0        0.489   1.84835e-10
     8          2.023227       13.9492       1.73017     -0.004065      0.000545      3          0            1   1.84835e-10
     9          2.787590       15.4567       1.50748     -0.003498      0.000431      1          0            1   6.16115e-11
    10          2.831207       15.5377     0.0809828     -0.000011      0.000001      1          0       0.0597   2.05372e-11
    11          3.010587       15.8659       0.32816     -0.000182      0.000010      1          0        0.243   2.05372e-11
    12          3.172032       16.1548      0.288975     -0.000144      0.000007      2          0        0.219   2.05372e-11
    13          3.936995       17.4529       1.29807     -0.002980      0.000348      1          0            1   2.05372e-11

 ========== Varying R13 exch upward from 95.17 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.397129       2.25005       2.25005      0.015990      1.304935      6          0        0.186   1.66351e-09
     2         -1.208450        8.0758       5.82576      0.030097      0.609711      4          0            1   1.66351e-09
     3         -0.700455       11.5969       3.52114     -0.006460      0.253836      2          0            1   5.54504e-10
     4         -0.218585       13.3245       1.72756     -0.003844      0.000810      1          0        0.675   1.84835e-10
     5         -0.103227        13.683      0.358451     -0.000202      0.000005      1          0        0.168   1.84835e-10
     6          0.656609       15.7393       2.05634     -0.006766      0.001689      1          0            1   1.84835e-10
     7          1.257496       17.1209       1.38158     -0.003782      0.000451      1          0        0.801   6.16115e-11
     8          2.019777       18.6822       1.56129     -0.005257      0.000754      1          0            1   6.16115e-11
     9          2.782732       20.0954       1.41325     -0.004747      0.000590      1          0            1   2.05372e-11
    10          3.546166       21.4003       1.30485     -0.004364      0.000493      1          0            1   6.84573e-12
    11          4.309965       22.6214       1.22113     -0.004059      0.000434      1          0            1   2.28191e-12

 ========== Varying R13 exch downward from 95.17 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.397515       11.1421       11.1421      0.132458      1.633341      4         11            1       1.78618
     2         -1.397515       25.9382       14.7961      0.248316      0.370532      5          0            1      0.595394
     3         -1.397515       38.8112       12.8729      0.129279      0.302631      4          2            1       1.58772
     4         -1.397515       60.4405       21.6294      0.731636      0.829979      4          0            1      0.529239
     5         -1.397515       81.0849       20.6443      0.635109      0.813742      6          1            1      0.432421
     6         -1.185728       95.1749       14.0901      0.270665      0.414664     31          0        0.846       0.14414

 ========== Varying R15 upward from 107.8 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.353425       2.62133       2.62133      0.015695      0.509840      4          0         0.39   1.66351e-09
     2          0.252410       5.72454       3.10321      0.001043      0.163497      3          0            1   1.66351e-09
     3          0.565663       6.87125       1.14671     -0.000206      0.045571      2          0        0.495   5.54504e-10
     4          1.265299       8.98076       2.10951     -0.000953      0.067703      2          0            1   5.54504e-10
     5          1.990973       10.7908          1.81     -0.000861      0.041756      2          0            1   1.84835e-10
     6          2.582601       12.0912       1.30041     -0.000526      0.021283      2          0        0.807   6.16115e-11
     7          3.333729       13.5852       1.49404     -0.000726      0.016437      3          0            1   6.16115e-11
     8          4.093864       14.9554       1.37021     -0.000500      0.007658      3          0            1   2.05372e-11

 ========== Varying R15 downward from 107.8 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.343001       10.4902       10.4902      0.002931      1.353961      6          0        0.126   1.66351e-09
     2         -1.397515       12.6481        2.1579      0.000066      0.000079      4          0        0.202   1.66351e-09
     3         -0.962243          16.3       3.65189      0.082594      0.228999      4         11            1       1.78618
     4         -0.559283       18.4792       2.17922      0.083638      0.402130      5          0            1      0.595394
     5          0.174982       20.5161       2.03689      0.234035      0.231386      3          0            1      0.198465
     6          0.933652       22.0799       1.56378      0.125606      0.115196      4          0            1      0.175649
     7          1.704016       23.3622       1.28233      0.084695      0.072802      1          0            1      0.108665
     8          1.887575       23.6363      0.274055      0.001017      0.000445      1          0        0.251     0.0519603
     9          2.661887       24.6931       1.05681      0.056672      0.046796      2          0            1     0.0519603
    10          3.244937       25.4046      0.711502      0.018876      0.014505     24          0        0.763     0.0186204
    11          3.965923       26.2085      0.803907      0.024652      0.019467     18          0        0.935     0.0186204

 ========== Varying R17 net upward from 88.57 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.425633       3.63973       3.63973      0.004533      0.857242      4          0        0.615   1.66351e-09
     2          0.325789       7.50335       3.86362     -0.015356      0.001511      1          0            1   1.66351e-09
     3          0.738598       9.28815        1.7848     -0.003852      0.000157      2          0        0.566   5.54504e-10
     4          1.126457       10.6139       1.32575      0.006109      0.006537      1          0         0.57   5.54504e-10
     5          1.894165       12.4804       1.86646      0.036205      0.036789      1          0            1   5.54504e-10
     6          2.662369       13.9174       1.43707      0.020889      0.020976      1          0            1   1.84835e-10
     7          2.719678       14.0142      0.096812      0.000003      0.000000      0          0       0.0799   6.16115e-11
     8          3.197986       14.7804      0.766113      0.002686      0.002672      1          0        0.639   6.16115e-11
     9          3.259685       14.8743     0.0939622      0.000005      0.000000      0          0       0.0849   6.16115e-11
    10          4.028100       15.9698       1.09549      0.012552      0.012429      1          0            1   6.16115e-11

 ========== Varying R17 net downward from 88.57 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.390273       10.8376       10.8376      0.004504      1.401112      7          0         0.13   1.66351e-09
     2         -1.397515       11.8632       1.02562      0.000061      0.001028      6          0       0.0823   1.66351e-09
     3         -0.746468       16.8974       5.03424      0.042453      0.159697      2          0            1   1.66351e-09
     4          0.032287       19.2399       2.34243      0.013656      0.003193      2          0            1   5.54504e-10
     5          0.807778       20.9479       1.70798      0.008982      0.001783      1          0            1   1.84835e-10
     6          1.581904        22.349        1.4011      0.011913      0.006078      2          0            1   6.16115e-11
     7          2.355273       23.5593       1.21038      0.006240      0.001164      1          0            1   2.05372e-11
     8          3.128145       24.6363       1.07692      0.031975      0.027395      1          0            1   6.84573e-12
     9          3.816610       25.5109       0.87464      0.003995      0.000624      1          0        0.895   2.28191e-12
    10          4.085315       25.8343      0.323378      0.000518      0.000040      1          0        0.357   2.28191e-12

 ========== Varying R17 exch upward from 0.001058 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1          0.000000   1.90335e+06   1.90335e+06      0.000000      0.000000      0          0            1   1.66351e-09
     2         -1.391025   1.90336e+06       10.8375      0.008260      1.405623      5          0         0.13   5.54504e-10
     3         -1.397515   1.90336e+06       1.02624      0.000033      0.000248      4          0       0.0823   5.54504e-10
     4         -0.746453   1.90336e+06       5.03549      0.042524      0.159753      3          0            1   5.54504e-10
     5         -0.136776   1.90336e+06       1.90722      0.007973      0.001476      2          0        0.814   1.84835e-10
     6          0.639168   1.90337e+06       1.80362      0.010817      0.003164      1          0            1   1.84835e-10
     7          0.701770   1.90337e+06      0.127779      0.000042      0.000005      1          0       0.0878   6.16115e-11
     8          1.476042   1.90337e+06       1.43413      0.007362      0.001382      1          0            1   6.16115e-11
     9          1.732787   1.90337e+06       0.42744      0.019898      0.019323      1          0        0.347   2.05372e-11
    10          1.784165   1.90337e+06     0.0831979      0.000023      0.000007      1          0       0.0705   2.05372e-11
    11          1.995703   1.90337e+06      0.334878      0.000393      0.000025      1          0        0.286   2.05372e-11
    12          2.768771   1.90337e+06        1.1338      0.005843      0.001066      1          0            1   2.05372e-11
    13          3.013374   1.90337e+06      0.333731      0.000470      0.000034      1          0        0.327   6.84573e-12
    14          3.785919   1.90337e+06      0.990068      0.005189      0.000936      1          0            1   6.84573e-12
    15          4.558187   1.90337e+06      0.908595      0.004896      0.000919      1          0            1   2.28191e-12

 ========== Varying R17 exch downward from 0.001058 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1          0.000000    0.00105833    0.00105833      0.000000      0.000000      0          0     5.56e-10   1.66351e-09

 ========== Varying R19 upward from 47.83 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.790928       3.57299       3.57299     -0.002301      1.160941      4          0        0.542   1.66351e-09
     2         -0.034486       9.04045       5.46746      0.028903      0.040753      1          0            1   1.66351e-09
     3          0.724808       13.1864       4.14597      0.005866      0.014864      1          0            1   5.54504e-10
     4          0.847827       13.7897      0.603237      0.000104      0.000318      1          0        0.171   1.84835e-10
     5          1.068569        14.836       1.04637     -0.000508      0.000097      1          0        0.304   1.84835e-10
     6          1.823930       17.6988       2.86277      0.198564      0.211495      3          0            1   1.84835e-10
     7          2.606464       20.0636       2.36485      0.188887      0.174644      1          0            1   1.63994e-10
     8          2.695269       20.3092       0.24553      0.000262      0.000099      1          0        0.121   1.42458e-10
     9          3.251495        21.761       1.45184      0.048426      0.042098      3          0        0.726   1.42458e-10
    10          4.003052       23.4684        1.7074      0.272679      0.262345      3          0        0.967   1.42458e-10

 ========== Varying R19 downward from 47.83 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.397237       6.86562       6.86562      0.006712      1.406356      7          0         0.13   1.66351e-09
     2         -0.645044       13.6096       6.74396      0.514216      0.530315      3          0            1   1.66351e-09
     3          0.121473       16.3866       2.77705      0.008545      0.010320      1          0            1   1.72809e-09
     4          0.890043        18.496       2.10942      0.002779      0.002501      1          0            1   5.76029e-10
     5          1.204402       19.2536      0.757547      0.000196      0.000213      1          0        0.427    1.9201e-10
     6          1.575712       20.0916      0.838029      0.000134      0.000168      1          0          0.5    1.9201e-10
     7          2.345259       21.6642       1.57257      0.001844      0.000589      1          0            1    1.9201e-10
     8          3.114558       23.0661       1.40195      0.001585      0.000577      1          0            1   6.40032e-11
     9          3.259639       23.3155      0.249327      0.000059      0.000031      1          0        0.195   2.13344e-11
    10          4.028739       24.5716       1.25614      0.001359      0.000551      1          0            1   2.13344e-11

 ========== Varying R21 upward from 47.83 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.241935       5.68922       5.68922      0.093374      1.004119     17          0        0.933   1.66351e-09
     2          0.393200       9.14857       3.45936      0.343296      0.476453      3          0            1   1.66351e-09
     3          1.083656        11.523       2.37445      0.188836      0.266672      4          0            1   1.66151e-09
     4          1.797531       13.4329       1.90984      0.135838      0.190254      4          0            1   1.44314e-09
     5          2.524613       15.0633       1.63046      0.107697      0.148907      4          0            1   1.05339e-09
     6          2.883873       16.2682       1.20489      0.045069      0.324655     16          0        0.838   6.60795e-10
     7          3.409536       17.2589      0.990682      0.021313      0.019562      2          0        0.693   6.60795e-10
     8          3.540040       17.4936      0.234658      0.000225      0.000153      1          0        0.176   6.60795e-10
     9          3.610035       17.6178      0.124196      0.000051      0.002766      3          0       0.0981   6.60795e-10
    10          3.811325       17.9686      0.350828      0.000685      0.000462      1          0         0.27   6.60795e-10
    11          3.863892       18.0588       0.09018      0.000027      0.001958      3          0       0.0735   6.60795e-10

 ========== Varying R21 downward from 47.83 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.397250       6.86562       6.86562      0.006712      1.406369      6          0         0.13   1.66351e-09
     2         -0.645059       13.6096       6.74397      0.538872      0.554973      3          0            1   1.66351e-09
     3          0.123545        16.371       2.76145      0.009027      0.008714      2          0            1   1.77221e-09
     4          0.891749       18.4812        2.1102      0.002231      0.002319      1          0            1   5.90737e-10
     5          1.252777       19.3485      0.867303      0.000073      0.000137      1          0        0.488   1.96912e-10
     6          2.018007       21.0197       1.67121      0.002000      0.005061      2          0            1   1.96912e-10
     7          2.787410       22.4874       1.46761      0.001684      0.000573      1          0            1   6.56374e-11
     8          3.059529       22.9704      0.483066      0.000177      0.000067      1          0        0.364   2.18791e-11
     9          3.828666       24.2547       1.28423      0.001665      0.000819      1          0            1   2.18791e-11
    10          4.295301       24.9842      0.729553      0.000455      0.000195      1          0        0.616   7.29305e-12

 ========== Varying R22 net upward from 88.57 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.661208       1.79197       1.79197      0.009709      0.557114     16          0        0.227   1.66351e-09
     2         -0.517330       3.01979       1.22782     -0.000826      0.000029      1          0        0.219   1.66351e-09
     3          0.239684       6.05958       3.03979      0.010836      0.022114      1          0            1   1.66351e-09
     4          0.315238       6.25756      0.197985     -0.000046      0.000004      1          0        0.115   5.54504e-10
     5          1.079014       7.93181       1.67425     -0.000986      0.003530      1          0            1   5.54504e-10
     6          1.843921       9.26487       1.33306     -0.001673      0.001712      1          0            1   1.84835e-10
     7          1.972145       9.46752      0.202647     -0.000074      0.000007      1          0        0.177   6.16115e-11
     8          2.190505       9.80185      0.334326     -0.000194      0.000032      1          0        0.298   6.16115e-11
     9          2.250114       9.89093     0.0890819     -0.000015      0.000001      1          0       0.0822   6.16115e-11
    10          3.015771       10.9651        1.0742     -0.001481      0.001154      1          0            1   6.16115e-11
    11          3.077965       11.0474     0.0822891     -0.000014      0.000002      1          0       0.0847   2.05372e-11
    12          3.656104       11.7831      0.735637     -0.001030      0.000308      1          0        0.763   2.05372e-11
    13          4.065851       12.2763       0.49322     -0.000531      0.000101      1          0        0.544   2.05372e-11

 ========== Varying R22 net downward from 88.57 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.389705       10.8376       10.8376      0.004504      1.400544      5          0         0.13   1.66351e-09
     2         -1.397420       11.9182        1.0806      0.000445      0.029609      6          0        0.204   1.66351e-09
     3         -1.343467       13.3373       1.41913      0.000886      0.012855      1          0        0.285   1.66351e-09
     4         -0.549874       17.5884       4.25107      0.038326      0.013025      1          0            1   1.66351e-09
     5          0.227612       19.7096       2.12118      0.012318      0.003123      1          0            1   5.54504e-10
     6          1.002656       21.3231       1.61352      0.008536      0.001784      1          0            1   1.84835e-10
     7          1.672549       22.4992       1.17611      0.005050      0.000849      1          0        0.874   6.16115e-11
     8          2.445838       23.6916        1.1924      0.006141      0.001144      1          0            1   6.16115e-11
     9          3.218645       24.7554       1.06377      0.006119      0.001604      1          0            1   2.05372e-11
    10          3.991114        25.722      0.966586      0.005462      0.001284      1          0            1   6.84573e-12

 ========== Varying R22 exch upward from 1e-07 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.000002   1.90335e+06   1.90335e+06      0.000000      0.000000      0          0            1   1.66351e-09
     2         -1.397515   1.90336e+06       10.8341      0.004465      1.408320      7          0         0.13   5.54504e-10
     3         -0.746452   1.90336e+06       5.03549      0.042796      0.160025      2          0            1   5.54504e-10
     4          0.032307   1.90337e+06       2.34241      0.013627      0.003159      1          0            1   1.84835e-10
     5          0.809476   1.90337e+06       1.70795      0.009081      0.000204      1          0            1   6.16115e-11
     6          1.581157   1.90337e+06       1.39984      0.007485      0.004095      3          0            1   2.05372e-11
     7          2.354519   1.90337e+06       1.21052      0.006200      0.001130      1          0            1   6.84573e-12
     8          3.127374   1.90337e+06       1.07703      0.005617      0.001053      3          0            1   2.28191e-12
     9          3.899866   1.90337e+06      0.976832      0.005130      0.000930      2          0            1   7.60636e-13

 ========== Varying R22 exch downward from 1e-07 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda

 ========== Varying R24 net upward from 72.25 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.001495       57.0702       57.0702     -0.000007      0.000000      0          0       0.0985   1.66351e-09
     2         -0.560495       59.9825       2.91227      0.017172      0.446581      4          0        0.187   1.66351e-09
     3         -0.469935       60.9725      0.990036     -0.000398      0.000007      1          0        0.138   1.66351e-09
     4          0.279935        65.544       4.57147     -0.001256      0.017166      2          0            1   1.66351e-09
     5          1.039572       68.3339       2.78992     -0.006948      0.001706      1          0            1   5.54504e-10
     6          1.402345       69.4448       1.11091     -0.001409      0.000059      1          0        0.498   1.84835e-10
     7          2.164843       71.5107       2.06586     -0.005360      0.000434      1          0            1   1.84835e-10
     8          2.437542       72.1842      0.673524     -0.000615      0.000017      1          0         0.37   6.16115e-11
     9          2.673551       72.7452      0.561021     -0.000439      0.000012      1          0         0.32   6.16115e-11
    10          3.437312        74.446       1.70073     -0.004306      0.000224      1          0            1   6.16115e-11
    11          4.201529       76.0085       1.56257     -0.003895      0.000180      1          0            1   2.05372e-11

 ========== Varying R24 net downward from 72.25 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.397515       13.1492       13.1492      0.005144      1.407450      4          0        0.105   1.66351e-09
     2         -1.358652       15.0832       1.93405      0.000509      0.001545      1          0        0.228   1.66351e-09
     3         -0.560776       21.9178        6.8346      0.037303      0.007719      1          0            1   1.66351e-09
     4          0.216867       25.1978       3.28001      0.010770      0.001419      2          0            1   5.54504e-10
     5          0.991585       27.6886       2.49076      0.007359      0.000933      1          0            1   1.84835e-10
     6          1.764951       29.7667       2.07808      0.005834      0.000759      1          0            1   6.16115e-11
     7          1.875380       30.0397      0.273065      0.000098      0.000006      1          0        0.151   2.05372e-11
     8          2.230877       30.8861      0.846394      0.000997      0.000118      1          0        0.475   2.05372e-11
     9          2.291637       31.0262      0.140048      0.000027      0.000002      1          0       0.0827   2.05372e-11
    10          3.063706       32.7057       1.67949      0.004467      0.000689      1          0            1   2.05372e-11
    11          3.835353       34.2308       1.52514      0.003963      0.000608      1          0            1   6.84573e-12
    12          4.606635       35.6354       1.40459      0.003576      0.000586      1          0            1   2.28191e-12

 ========== Varying R24 exch upward from 10.35 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.397515       8.85734       8.85734      0.015408      1.320762      5          0        0.189   1.66351e-09
     2         -1.397271        31.472       22.6146     -0.056577      0.711471      3          0            1   1.66351e-09
     3         -1.397464       51.2465       19.7745     -0.026396      0.370359      3          0        0.718   5.54504e-10
     4         -1.397515       73.4815        22.235     -0.023358      0.340548      3          0        0.688   5.54504e-10
     5         -1.397515       101.572       28.0906     -0.021045      0.394000      4          0        0.735   5.54504e-10
     6         -1.383848       110.543       8.97132     -0.001759      0.013222      1          0        0.193   5.54504e-10
     7         -1.316294       124.688       14.1442     -0.003503      0.001528      2          0        0.231   5.54504e-10
     8         -1.153627       141.767       17.0796     -0.012853      0.004427      1          0        0.381   5.54504e-10
     9         -1.057151       149.302       7.53505     -0.003001      0.000174      1          0        0.183   5.54504e-10
    10         -1.359927       189.151       39.8487     -0.048863      1.022205      4          0            1   5.54504e-10
    11         -1.397515       268.184       79.0334      0.104243      0.910123      6          0            1   1.84835e-10
    12         -1.397515       380.643       112.458      0.156155      0.924447      4          0            1   1.13333e-10
    13         -1.397502        557.52       176.877      0.449297      1.217576      9          0            1   8.96398e-11
    14         -1.397515       704.568       147.049     -0.012953      0.113678      3          0        0.406   9.00771e-11
    15         -1.397510       1127.38       422.813      0.317099      1.085385      3          0            1   9.00771e-11
    16         -1.397515       1728.57       601.187      0.107445      0.410880      4          0        0.628   8.95981e-11
    17         -1.397515       3663.76       1935.19      0.529627      1.297919      5          0            1   8.95981e-11
    18         -1.397500       11221.7       7557.89      0.690778      1.411891      4          0        0.969   9.44648e-11
    19         -1.396924       59460.1       48238.4      0.638684      0.638108      1          0       0.0598   9.44648e-11
    20         -1.397052   1.13684e+06   1.07738e+06      0.566414      0.566542      1          0         0.73   9.44648e-11
    21         -1.397515   2.34024e+06    1.2034e+06     -0.000056      0.000407      2          0        0.979   9.44648e-11
    22         -1.397515    4.4695e+06   2.12926e+06      0.000000      0.000000      0          0            1   9.44648e-11
    23         -1.397515   7.02757e+06   2.55807e+06      0.000000      0.000000      0          0            1   3.14883e-11
    24         -1.397515   8.18715e+06   1.15959e+06      0.000000      0.000000      0          0        0.823   1.04961e-11
    25         -1.397515   9.99999e+06   1.81283e+06      0.000000      0.000000      0          0        0.613   1.04961e-11

 ========== Varying R24 exch downward from 10.35 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.397515       10.3484       10.3484      0.002013      1.399528      4          0     7.76e-06   1.66351e-09

 ========== Varying R27 upward from 97.03 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.352750       2.10082       2.10082      0.009813      1.282162      7          0        0.176   1.66351e-09
     2         -1.376156       2.43434      0.333515      0.000046      0.003175      1          0       0.0525   1.66351e-09
     3         -1.397321       3.19675      0.762408      0.000015      0.000013      1          0        0.128   1.66351e-09
     4         -0.896777       8.33205        5.1353      0.015739      0.283487      6          0            1   1.66351e-09
     5         -0.239143       10.4955       2.16349     -0.001039      0.001409      1          0        0.884   5.54504e-10
     6          0.526334       12.3006       1.80508     -0.001175      0.001639      2          0            1   5.54504e-10
     7          0.759322        12.774      0.473373     -0.000068      0.000030      1          0        0.322   1.84835e-10
     8          1.526744       14.1742        1.4002     -0.000160      0.000710      1          0            1   1.84835e-10
     9          2.294321       15.3998       1.22563     -0.000163      0.000552      1          0            1   6.16115e-11
    10          2.469847       15.6616      0.261796     -0.000021      0.000015      1          0        0.237   2.05372e-11
    11          3.124987       16.5898      0.928216     -0.000152      0.000290      2          0        0.859   2.05372e-11
    12          3.892747       17.5959       1.00608     -0.000084      0.000447      1          0            1   2.05372e-11

 ========== Varying R27 downward from 97.03 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1          0.345535       3.31443       3.31443     -0.001602      0.421153      4          0            1   1.66351e-09
     2          0.735137       5.09163       1.77721      0.001472      0.380162      4          0            1   5.54504e-10
     3          1.505646       6.45094       1.35931      0.002405      0.000187      1          0            1   1.84835e-10
     4          2.275799       7.61687       1.16592      0.002033      0.000172      2          0            1   6.16115e-11
     5          2.649440        8.1331      0.516235      0.000414      0.000029      1          0        0.499   2.05372e-11
     6          2.662479       8.15063      0.017525      0.000001      0.000000      0          0            1   2.05372e-11
     7          3.432320       9.13488       0.98425      0.001845      0.000295      2          0            1   6.84573e-12
     8          4.202033       10.0356      0.900707      0.001543      0.000122      1          0            1   2.28191e-12

 ========== Varying R29 upward from 40.74 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.657186       2.00427       2.00427      0.026869      0.644231      5          0        0.244   1.66351e-09
     2          0.084764       4.69368       2.68941     -0.018565      0.007776      1          0            1   1.66351e-09
     3          0.770555       6.70603       2.01235     -0.014801      0.001395      1          0        0.921   5.54504e-10
     4          1.398524       8.24592       1.53989     -0.000914      0.002652      1          0        0.837   5.54504e-10
     5          2.162448       9.83534       1.58942     -0.002082      0.002286      1          0            1   5.54504e-10
     6          2.553002       10.5675       0.73218     -0.000851      0.000124      1          0        0.525   1.84835e-10
     7          3.111520       11.5448      0.977252     -0.001565      0.000324      1          0         0.74   1.84835e-10
     8          3.208516       11.7073      0.162573     -0.000049      0.000002      1          0        0.132   1.84835e-10
     9          3.972454       12.9197       1.21234     -0.004175      0.000179      1          0            1   1.84835e-10

 ========== Varying R29 downward from 40.74 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.389875       4.27918       4.27918      0.001454      1.404795      6          0        0.135   1.66351e-09
     2         -1.397515       4.81717      0.537989      0.000094      0.000190      3          0        0.089   1.66351e-09
     3         -0.935852       8.74902       3.93186      0.083776      0.238062      2         11            1       1.78618
     4         -0.230615       10.9988       2.24976      0.081971      0.111390      3          0            1      0.595394
     5          0.528414       12.6654       1.66665      0.117962      0.112100      3          0            1      0.198465
     6          1.295792       13.9982       1.33271      0.123156      0.115614      1          0            1      0.120527
     7          2.068066       15.1181       1.11992      0.079170      0.070223      1          0            1     0.0789355
     8          2.202467       15.2964      0.178337      0.000364      0.000108      1          0        0.183     0.0374763
     9          2.976526       16.2493      0.952863      0.059319      0.051182      5          0            1     0.0374763
    10          3.162173       16.4616      0.212326      0.000732      0.000351      4          0        0.249     0.0143186
    11          3.244998       16.5545     0.0929437      0.000104      0.000043      3          0        0.112     0.0143186
    12          3.299237       16.6148     0.0602997      0.000042      0.000004      2          0       0.0734     0.0143186
    13          4.072945       17.4306      0.815716      0.046887      0.040512     13          0            1     0.0143186

 ========== Varying R30 upward from 57.06 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.397515       2.58077       2.58077      0.016159      1.374609      6          0        0.184   1.66351e-09
     2         -1.397515       8.35691       5.77613      0.558563      1.224205      3          0        0.931   1.66351e-09
     3         -1.397515       14.1324       5.77548      0.560969      1.226462      4          0        0.931   1.66351e-09
     4         -1.397515       19.9079       5.77547      0.563416      1.228906      3          0        0.931   1.66351e-09
     5         -1.397515       25.6833       5.77546      0.566087      1.231575      3          0        0.931   1.66351e-09
     6         -1.397515       31.4588       5.77544      0.569113      1.234596      3          0        0.931   1.66351e-09
     7         -1.397515       37.2342       5.77542      0.572700      1.238179      4          0        0.931   1.66351e-09
     8         -1.397515       43.0103        5.7761      0.577026      1.242661      3          0        0.931   1.66351e-09
     9         -1.397515       48.7856       5.77536      0.583177      1.248641      3          0        0.931   1.66351e-09
    10         -1.397514        54.561       5.77532      0.591811      1.257263      3          0        0.931   1.66351e-09
    11         -1.397512       60.3362       5.77524      0.605572      1.271003      3          0        0.931   1.66351e-09
    12         -1.397496       66.1113       5.77511      0.630821      1.296202      3          0        0.931   1.66351e-09
    13         -1.397422       71.8861       5.77479      0.688666      1.353904      4          0        0.931   1.66351e-09
    14         -1.397515        77.705       5.81885      0.132893      0.842474      4         10            1      0.223273
    15         -1.158441       97.0992       19.3943      0.502551      0.563701     16          0        0.856      0.105872
    16         -0.581680       101.934       4.83448      0.011126      0.158338      6          0            1      0.105872
    17          0.180382       104.584       2.65018     -0.003499      0.002240      1          0            1     0.0352906
    18          0.390588       105.166       0.58243     -0.000286      0.000010      1          0        0.298     0.0117635
    19          1.153844       106.996       1.82954     -0.004733      0.000277     14          0            1     0.0117635
    20          1.917987       108.538       1.54252     -0.003863      0.000280      9          0            1    0.00392118
    21          2.681905       109.902       1.36354     -0.003349      0.001023      3          0            1    0.00130706
    22          3.351441        111.14       1.23845     -0.003001      0.095751     26          0            1   0.000435687
    23          4.117124       112.322       1.18163     -0.002409      0.000194      1          0            1   0.000145229

 ========== Varying R30 downward from 57.06 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.000001       57.0575       57.0575     -0.000004      0.000000      0          0       0.0994   1.66351e-09

 ========== Varying R31 net upward from 82.6 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.397515       4.02726       4.02726      0.010627      1.271165      6          0        0.171   1.66351e-09
     2         -1.397515       12.0588       8.03154      0.001407      0.044947      5          0        0.238   1.66351e-09
     3         -1.338458       21.3302       9.27138      0.003319      0.712553      3          0            1   1.66351e-09
     4         -1.212176       27.2018       5.87164     -0.001471      0.000221      1          0        0.305   5.54504e-10
     5         -0.485102       42.6142       15.4124     -0.020887      0.007582      1          0        0.988   5.54504e-10
     6         -1.397486       48.7209       6.10668      0.069695      1.750371     18          0            1   5.54504e-10
     7         -1.397512       56.5402       7.81932      0.001206      0.044651     14          0        0.233   2.50363e-10
     8         -1.397426       64.5006       7.96041      0.001378      0.044797     32          0        0.236   2.50363e-10
     9         -1.394794        66.353       1.85235      0.000028      0.000225      4          0       0.0536   2.50363e-10
    10         -1.341257       73.4325       7.07956      0.001889      0.001964      1          0        0.224   2.50363e-10
    11         -0.617875       93.3788       19.9463     -0.039954      0.004954      3          0            1   2.50363e-10
    12         -0.617857       93.3792   0.000377502      0.000000      0.000000      0          0            1   8.34545e-11
    13         -0.057175       101.892       8.51329     -0.010516      0.000954      3          0        0.775   2.78182e-11
    14          0.070875       103.543       1.65075     -0.000077      0.000055      1          0        0.201   2.78182e-11
    15          0.829899       109.235       5.69144      0.011492      0.020761      4          0            1   2.78182e-11
    16          1.593747       112.774       3.53962      0.001120      0.005563      3          0            1   9.27272e-12
    17          1.631397       112.926      0.151765     -0.000008      0.000000      0          0       0.0538   3.09091e-12
    18          2.396390       115.723       2.79718      0.000074      0.003373      3          0            1   3.09091e-12
    19          2.599907       116.395      0.671369     -0.000162      0.000035      2          0        0.279    1.0303e-12
    20          3.365589       118.726       2.33101     -0.000167      0.002442      3          0            1    1.0303e-12
    21          4.131584       120.822       2.09618     -0.000151      0.002145      3          0            1   3.43434e-13

 ========== Varying R31 net downward from 82.6 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.382527       21.8626       21.8626      0.003770      1.392727      6          0         0.13   1.66351e-09
     2         -1.397515       25.1347       3.27213      0.000013      0.000014      3          0        0.121   1.66351e-09
     3         -1.331697       27.8234       2.68875     -0.000074      0.000475      1          0        0.294   1.66351e-09
     4         -0.565114       34.7091       6.88565      0.002244      0.003954      1          0            1   1.66351e-09
     5          0.202104       38.4196       3.71049     -0.000146      0.000927      1          0            1   5.54504e-10
     6          0.703434       40.3681       1.94854     -0.000195      0.000218      1          0        0.675   1.84835e-10
     7          1.470784       42.9483       2.58016     -0.000388      0.000553      1          0            1   1.84835e-10
     8          2.238160       45.2056       2.25732     -0.000414      0.000501      1          0            1   6.16115e-11
     9          3.005549       47.2391       2.03348     -0.000429      0.000474      1          0            1   2.05372e-11
    10          3.231878        47.805       0.56596     -0.000043      0.000035      1          0        0.303   6.84573e-12
    11          3.999276         49.63       1.82499     -0.000440      0.000454      1          0            1   6.84573e-12

 ========== Varying R31 exch upward from 47.69 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.092443       25.7415       25.7415     -0.028528      1.355278      6          0        0.744   1.66351e-09
     2         -0.365743       40.6209       14.8794     -0.029065      0.012526      3          0            1   1.66351e-09
     3         -0.217766       42.9973       2.37641     -0.000983      0.000041      1          0        0.217   5.54504e-10
     4          0.512297       53.2398       10.2424     -0.017577      0.001966      1          0        0.978   5.54504e-10
     5          1.263634       62.2222        8.9824     -0.014820      0.002135      1          0            1   5.54504e-10
     6          1.421272       63.9777       1.75558     -0.000616      0.000029      1          0        0.217   1.84835e-10
     7          2.174928       71.9285       7.95079     -0.013395      0.001240      1          0            1   1.84835e-10
     8          2.507285       75.2465       3.31798     -0.002433      0.000144      1          0        0.448   6.16115e-11
     9          2.589731       76.0548       0.80829     -0.000146      0.000006      1          0        0.112   6.16115e-11
    10          2.990667       79.9109        3.8561     -0.003408      0.000203      1          0        0.538   6.16115e-11
    11          3.746455       86.8931        6.9822     -0.011499      0.001004      1          0            1   6.16115e-11
    12          3.893627       88.2157       1.32259     -0.000422      0.000021      1          0        0.198   2.05372e-11

 ========== Varying R31 exch downward from 47.69 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.054962       7.30131       7.30131      0.002668      1.169995      5          0        0.258   1.66351e-09
     2         -0.256388       20.1713         12.87      0.041987      0.011706      3          0            1   1.66351e-09
     3          0.531351       28.2069       8.03565      0.021344      0.001897      1          0            1   5.54504e-10
     4          1.313750       34.4221       6.21512      0.015790      0.001682      2          0            1   1.84835e-10
     5          2.076561       39.6236       5.20156      0.012130      0.017610      2          0            1   6.16115e-11
     6          2.851897        44.287       4.66341      0.008079      0.001035      2          0            1   2.05372e-11
     7          3.470361       47.6909       3.40387      0.004245      0.004611      3          0        0.812   6.84573e-12

 ========== Varying R33 upward from 6.486e-05 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1          0.000000       147.064       147.064      0.000000      0.000000      0          0       0.0994   1.66351e-09
     2         -1.150194       154.003       6.93867      0.032416      1.182712      6          0        0.322   1.66351e-09
     3         -1.081331       155.567       1.56447     -0.000002      0.000000      0          0        0.132   1.66351e-09
     4         -1.014562       156.514      0.946427      0.000013      0.000179      1          0        0.202   1.66351e-09
     5         -0.761514       158.343       1.82922     -0.000519      0.000670      1          0        0.458   1.66351e-09
     6          0.000046       161.355       3.01177     -0.002494      0.004238      1          0            1   1.66351e-09
     7          0.316365       162.277      0.922122     -0.000672      0.000054      1          0        0.445   5.54504e-10
     8          1.079658       164.146       1.86979     -0.004862      0.000138      2          0            1   5.54504e-10
     9          1.843918       165.712       1.56532     -0.003931      0.000100      1          0            1   1.84835e-10
    10          2.608739        167.09       1.37862     -0.003393      0.000078      2          0            1   6.16115e-11
    11          3.373929        168.34       1.24909     -0.003032      0.000070      1          0            1   2.05372e-11
    12          4.139386       169.492       1.15248     -0.002769      0.000065      1          0            1   6.84573e-12

 ========== Varying R33 downward from 6.486e-05 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1          0.000000   6.47557e-05   6.47557e-05      0.000000      0.000000      0          0     4.38e-08   1.66351e-09

 ========== Varying R34 net upward from 2.971 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.360171       2.65863       2.65863     -0.016650      2.111814      4          0            1   1.66351e-09
     2         -0.594169       4.93083        2.2722      0.050063      0.052353      1          0            1   5.54504e-10
     3          0.173124       6.08447       1.15364      0.005254      0.006253      1          0            1   1.89769e-10
     4          0.940602       6.97763      0.893161      0.002043      0.002857      1          0            1   6.32563e-11
     5          1.087148       7.13059      0.152963     -0.000017      0.000009      1          0        0.202   2.10854e-11
     6          1.805162       7.82263      0.692041      0.000809      0.001422      3          0        0.939   2.10854e-11
     7          2.081652       8.06829      0.245658     -0.000036      0.000046      1          0        0.373   2.10854e-11
     8          2.849321       8.70383      0.635545      0.000728      0.001350      1          0            1   2.10854e-11
     9          3.116545       8.91155      0.207713     -0.000030      0.000036      1          0        0.357   7.02848e-12
    10          3.884265       9.47674      0.565191      0.000485      0.001057      1          0            1   7.02848e-12

 ========== Varying R34 net downward from 2.971 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.968611       3.92215       3.92215      0.013711      1.088503      4          0        0.266   1.66351e-09
     2         -0.207975       6.37853       2.45638     -0.006838      0.000818      1          0            1   1.66351e-09
     3          0.478021       7.95695       1.57842     -0.003676      0.000293      1          0        0.908   5.54504e-10
     4          1.242162       9.41302       1.45607     -0.003791      0.000359      1          0            1   5.54504e-10
     5          2.006782       10.6808       1.26775     -0.003326      0.000347      1          0            1   1.84835e-10
     6          2.051027       10.7498     0.0690514     -0.000010      0.000000      0          0       0.0605   6.16115e-11
     7          2.815927       11.8848       1.13502     -0.002963      0.000429      1          0            1   6.16115e-11
     8          3.581082        12.929       1.04411     -0.002782      0.000355      1          0            1   2.05372e-11
     9          4.346400       13.9027      0.973791     -0.002629      0.000345      1          0            1   6.84573e-12

 ========== Varying R34 exch upward from 95.81 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.313478       10.1266       10.1266      0.062938      1.461328      6          0        0.364   1.66351e-09
     2         -0.817297       24.3689       14.2423      0.332822      0.412083      2         11            1       1.78618
     3         -0.184795       34.8003       10.4314      0.190523      0.237697      3          0            1       1.32748
     4         -0.184789       35.2561      0.455807     -0.000037      0.033162      3          0       0.0538      0.800991
     5         -0.112731        36.255      0.998953     -0.000160      0.000349      1          0        0.119      0.800991
     6          0.563016       44.4889        8.2339      0.072947      0.109868      4          0            1      0.800991
     7          0.678177       45.7376       1.24865     -0.000316      0.000220      1          0         0.17      0.266997
     8          1.400607       52.9043       7.16672      0.042286      0.064338      6          0            1      0.266997
     9          1.571150       54.4662        1.5619     -0.000492      0.000450      2          0         0.24     0.0889991
    10          2.309843       60.8414       6.37525      0.029858      0.049584     26          0            1     0.0889991
    11          2.560833       62.8957       2.05427     -0.000202      0.001804      1          0        0.344     0.0296664
    12          3.303590       68.7464       5.85073      0.024974      0.045578     14          0            1     0.0296664
    13          3.567546       70.7628       2.01634     -0.000147      0.002313     16          0        0.358    0.00988878
    14          4.311040       76.3238       5.56099      0.016600      0.038489     13          0            1    0.00988878

 ========== Varying R34 exch downward from 95.81 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.239243       12.0165       12.0165      0.221611      0.442434      5          0        0.359   1.66351e-09
     2         -0.346708       23.6884       11.6719      0.232684      1.108441      4          0            1   1.66351e-09
     3          0.230647       29.3708       5.68247      0.020508      0.009141      1          0        0.762   1.56155e-09
     4          1.016580       35.3974       6.02654      0.024602      0.006961      1          0            1   1.56155e-09
     5          1.070817       35.7646      0.367256      0.000072      0.000001      1          0       0.0754   5.20516e-10
     6          1.854909       40.5311       4.76645      0.017469      0.001669      1          0            1   5.20516e-10
     7          2.636526       44.5304       3.99929      0.014342      0.001017      1          0            1   1.73505e-10
     8          3.416531       48.0077       3.47736      0.013156      0.001443      1          0            1   5.78351e-11
     9          3.855498       49.7916       1.78382      0.003515      0.000139      1          0        0.577   1.92784e-11

 ========== Varying R36 net upward from -104.9 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.392278        1.9279        1.9279      0.017706      1.405611      8          0        0.191   1.66351e-09
     2         -1.345344       3.08871        1.1608      0.000931      0.000563      1          0        0.192   1.66351e-09
     3         -1.322468       3.35874      0.270032      0.000047      0.000017      1          0        0.101   1.66351e-09
     4         -0.553242       5.77319       2.41446      0.106691      0.105757      4          0            1   1.66351e-09
     5          0.215624        6.9702       1.19701      0.013786      0.013211      3          0            1   1.03674e-09
     6          0.985320       7.88997       0.91977      0.007099      0.005696      1          0            1   3.45578e-10
     7          1.754482       8.66484      0.774864      0.004998      0.004127      2          0            1   1.15193e-10
     8          2.523330       9.34732       0.68249      0.004026      0.003469      3          0            1   3.83976e-11
     9          2.563979       9.38141       0.03409      0.000003      0.000000      0          0       0.0553   1.27992e-11
    10          2.639674       9.44442     0.0630028      0.000009      0.000000      0          0        0.103   1.27992e-11
    11          3.407986       10.0529      0.608477      0.003620      0.003600      2          0            1   1.27992e-11
    12          4.176203       10.6139      0.560989      0.003512      0.003587      2          0            1    4.2664e-12

 ========== Varying R36 net downward from -104.9 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.687268        1.5981        1.5981      0.023484      1.153725      3          0        0.689   1.66351e-09
     2         -0.495488        2.0262      0.428096     -0.000364      0.002327      1          0        0.293   1.66351e-09
     3          0.265057       3.28395       1.25775      0.000887      0.008634      1          0            1   1.66351e-09
     4          1.027062       4.29158       1.00764     -0.002542      0.003745      1          0            1   5.54504e-10
     5          1.043038       4.34265     0.0510713     -0.000016      0.026123      3          0       0.0586   1.84835e-10
     6          1.799197       5.21031      0.867659     -0.002982      0.002636      1          0        0.992   1.84835e-10
     7          2.564221        5.9932      0.782887      0.015144      0.018411      1          0            1   1.84835e-10
     8          3.329535       6.70473      0.711524      0.014930      0.017907      1          0            1   6.16115e-11
     9          4.095059       7.36261      0.657885      0.015775      0.018543      1          0            1   2.05372e-11

 ========== Varying R36 exch upward from 1e-07 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.382666       34.1574       34.1574      0.223347      1.405767      7          0        0.314   1.66351e-09
     2         -1.329560       90.0634        55.906      0.182646      0.306276      1         11            1       1.78618
     3         -1.075213        169.79       79.7267      0.128378      0.260731      3          0            1      0.595394
     4         -1.011858       189.171       19.3809     -0.003738      0.000258      1          0         0.14      0.198465
     5         -0.603185       338.505       149.334      0.143933      0.369061      4          0            1      0.198465
     6         -0.165521       608.218       269.713      0.061416      0.346929      4          0            1     0.0661549
     7          0.115187       948.819       340.601     -0.082682      0.062046      7          0        0.597     0.0220516
     8          0.434064       1889.46       940.642     -0.114218      0.188840     14          0        0.856     0.0220516
     9          0.678568       5261.73       3372.27     -0.121455      0.331301      7          0            1     0.0220516
    10          0.800183         26591       21329.3     -0.122866      0.402761     20          0            1    0.00735054
    11          0.829330        352312        325721     -0.170205      0.201259     10          0            1    0.00245018
    12          0.831365   2.38999e+06   2.03768e+06     -0.011620      0.000219      4          0            1   0.000816727
    13          0.831576   5.95046e+06   3.56046e+06     -0.000315      0.000000      1          0            1   0.000272242
    14          0.831634    9.9999e+06   4.04944e+06     -0.000039      0.000000      1          0        0.656   9.07474e-05
    15          0.846371    9.9999e+06        1.1071      0.021315      0.017738      3          0        0.124   9.07474e-05
    16          1.430173    9.9999e+06       1.83831      0.015324      0.111247     16          6            1       2.97361
    17          2.133416    9.9999e+06       1.01549      0.017922      0.058810      2          0            1      0.991204
    18          2.883190    9.9999e+06      0.804303      0.017869      0.029227      3          0            1      0.330401
    19          3.644459   9.99991e+06      0.685328      0.003692      0.008831      1          0            1      0.110134
    20          4.407445   9.99991e+06      0.605528      0.000934      0.005739      1          0            1     0.0367113

 ========== Varying R36 exch downward from 1e-07 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda

 ========== Varying R38 net upward from -36.04 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.394524        1.7057        1.7057      0.014678      1.412467      7          0        0.188   1.66351e-09
     2         -1.352948       2.73377       1.02806      0.001093      0.000824      2          0         0.19   1.66351e-09
     3         -0.576384       4.20692       1.47316      0.114228      0.105956      3          0            1   1.66351e-09
     4          0.194661        4.8549      0.647973      0.012672      0.009919      1          0            1   1.08643e-09
     5          0.336815       4.95465     0.0997533      0.000095      0.000051      1          0        0.201   3.62145e-10
     6          1.106807       5.43315      0.478497      0.006342      0.004642      3          0            1   3.62145e-10
     7          1.876380       5.83968      0.406531      0.004732      0.003452      1          0            1   1.20715e-10
     8          2.645628       6.19902      0.359342      0.004154      0.003197      1          0            1   4.02383e-11
     9          3.414633       6.52439      0.325369      0.003857      0.003144      1          0            1   1.34128e-11
    10          4.183374       6.82382       0.29943      0.003889      0.003441      2          0            1   4.47093e-12

 ========== Varying R38 net downward from -36.04 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.513501      0.688453      0.688453     -0.005350      0.924846      7          0        0.613   1.66351e-09
     2          0.182871       1.45683      0.768377     -0.006889      0.065030      3          0            1   1.66351e-09
     3          0.801938        1.9834      0.526569     -0.004006      0.000305      1          0        0.826   5.54504e-10
     4          1.534584       2.49802      0.514616     -0.002918      0.032728      4          0            1   5.54504e-10
     5          1.584905       2.53993     0.0419139     -0.000020      0.016792      2          0       0.0923   1.84835e-10
     6          2.349152       3.01805       0.47812     -0.003617      0.000428      1          0            1   1.84835e-10
     7          2.863036       3.31458      0.296532     -0.001526      0.000096      1          0        0.681   6.16115e-11
     8          3.627922       3.72741       0.41283     -0.003179      0.000226      1          0            1   6.16115e-11
     9          4.393024       4.11299      0.385577     -0.002976      0.000214      1          0            1   2.05372e-11

 ========== Varying R38 exch upward from 58.36 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.378382       15.3939       15.3939      0.147198      1.355182      5          0        0.247   1.66351e-09
     2         -1.387721       32.0237       16.6297     -0.030774      0.127640      2         12            1       14.2895
     3         -1.262987       60.3424       28.3187      0.235865      0.381616      4          0            1       4.76315
     4         -1.039125       101.368       41.0258      0.521738      0.673033      5          1            1       3.17543
     5         -1.006049       107.952        6.5841     -0.001304      0.000439      3          0        0.104       2.24066
     6         -0.779001       161.421        53.469      0.306167      0.416713      3          1            1       4.48132
     7         -0.755544       168.163       6.74185     -0.000716      0.000446      3          0       0.0639       1.49377
     8         -0.612152       215.825       47.6619      0.027229      0.063317      5          1        0.538       2.98755
     9         -0.592488       223.495       7.67029     -0.000552      0.000054      2          0       0.0687       2.98755
    10         -0.372890       338.576        115.08      0.446943      0.551708      3          0            1       2.98755
    11         -0.299788       395.131       56.5553     -0.003585      0.007129      1          0        0.224      0.995849
    12         -0.114415       628.737       233.606      0.465651      0.571371      4          1            1        1.9917
    13          0.033486       1033.71       404.971      0.329348      0.420117      5          0        0.709      0.663899
    14          0.116390        1524.1       490.395      0.030366      0.068182      3          0        0.495      0.663899
    15          0.211121       3033.43       1509.33      0.291365      0.384502      3          0            1      0.663899
    16          0.261708       5993.99       2960.56      0.055641      0.104919      1          0        0.579        0.2213
    17          0.296178       16602.2       10608.3      0.093179      0.154697      2          0            1        0.2213
    18          0.309686       51588.6       34986.4      0.004374      0.032967      1          0        0.677     0.0737666
    19          0.314606        216120        164531     -0.005729      0.010016      2          0            1     0.0737666
    20          0.315598        602358        386238     -0.001646      0.000128      1          0            1     0.0245889
    21          0.315890   1.27228e+06        669925     -0.000321      0.000004      2          0            1    0.00819629
    22          0.316016   2.43291e+06   1.16063e+06     -0.000114      0.000001      1          0            1     0.0027321
    23          0.316078   4.44335e+06   2.01044e+06     -0.000051      0.000000      2          0            1   0.000910698
    24          0.316111   7.92565e+06    3.4823e+06     -0.000026      0.000000      1          0            1   0.000303566
    25          0.316120   9.99991e+06   2.07426e+06     -0.000002      0.000000      0          0        0.344   0.000101189
    26          0.346277   9.99991e+06      0.456141     -0.000145      0.009343      4          0         0.22   0.000101189
    27          1.048611   9.99991e+06       1.50958      0.106377      0.172250      5          0            1   0.000101189
    28          1.227248   9.99991e+06       1.03356      0.006195      0.521920      3          0            1    6.2898e-05
    29          1.996263   9.99991e+06      0.712576      0.012689      0.011963      3          0            1    2.0966e-05
    30          2.765200   9.99991e+06       0.52753      0.005619      0.004973      3          0            1   6.98867e-06
    31          3.534061   9.99991e+06      0.437787      0.003691      0.003123      2          0            1   2.32956e-06
    32          4.302858   9.99991e+06      0.382026      0.002879      0.002373      2          0            1   7.76519e-07

 ========== Varying R38 exch downward from 58.36 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.905481       11.9011       11.9011      0.103809      1.143982      5          0        0.344   1.66351e-09
     2         -0.635670       17.7434       5.84237      0.020310      0.003671      1          0        0.388   1.66351e-09
     3          0.230401       28.1465       10.4031      0.151303      0.053524      2          0            1   1.66351e-09
     4          1.042046       33.9754       5.82886      0.051010      0.007657      1          0            1   1.29307e-09
     5          1.105372       34.3577      0.382277      0.000199      0.000006      1          0       0.0885   4.49736e-10
     6          1.902114       38.5963       4.23865      0.031371      0.002920      2          0            1   4.49736e-10
     7          2.379771       40.7537       2.15735      0.008686      0.000551      1          0        0.625   1.49912e-10
     8          3.161718       43.8561       3.10246      0.020178      0.006523      2          0            1   1.49912e-10
     9          3.266795       44.2401      0.383977      0.000303      0.000006      1          0        0.141   4.99706e-11
    10          4.050812       46.9078       2.66771      0.016676      0.000952      1          0            1   4.99706e-11

 ========== Varying R40 net upward from 26.93 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.211651       5.04098       5.04098      0.035422      1.289442      5          0        0.242   1.66351e-09
     2         -0.580347       14.0533       9.01227      0.471477      0.486739      1          0        0.885   1.66351e-09
     3         -0.227117       17.4588       3.40554      0.003141      0.007667      2          0        0.508   1.66351e-09
     4         -0.162480       18.0238      0.565031     -0.000088      0.000023      1          0       0.0954   1.66351e-09
     5          0.579028       23.6178       5.59403     -0.019215      0.007569      1          0            1   1.66351e-09
     6          1.326789       28.3016       4.68375     -0.017982      0.002549      1          0            1   5.54504e-10
     7          2.077381         32.49       4.18842     -0.016117      0.001583      1          0            1   1.84835e-10
     8          2.829858       36.3629       3.87293     -0.014988      0.000827      1          0            1   6.16115e-11
     9          3.583636       40.0151       3.65218      0.001189      0.015703      1          0            1   2.05372e-11
    10          4.338396       43.5041       3.48898     -0.013032      0.000499      1          0            1   6.84573e-12

 ========== Varying R40 net downward from 26.93 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.473358        5.1342        5.1342      0.080580      0.528210      5          0        0.275   1.66351e-09
     2         -0.454139       11.5212         6.387      0.073660      0.429556      4         12            1       14.2895
     3         -0.172603       17.8105       6.28933      0.237438      0.433239      3          0            1       4.76315
     4         -0.322975       22.7593       4.94872      0.376481      1.061451      5          1            1       3.17543
     5          0.125742       26.1652       3.40591      0.146549      0.320291     15          0            1       2.38784
     6          0.629157        28.994       2.82888      0.079523      0.259098     30          0            1      0.795945
     7          1.370893        31.078       2.08394      0.003388      0.016305      9          0            1      0.265315
     8          2.132467       32.5123       1.43431      0.000172      0.003494      5          0            1     0.0884383
     9          2.898810       33.6731       1.16081     -0.000520      0.000678      1          0            1     0.0294794
    10          3.078463       33.9195      0.246371     -0.000045      0.000019      2          0        0.246    0.00982648
    11          3.334473       34.2532      0.333682      0.000165      0.000023      1          0        0.353    0.00982648
    12          4.103954        35.148      0.894869      0.001527      0.000268      3          0            1    0.00982648

 ========== Varying R40 exch upward from 98.04 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.097616       3.18885       3.18885      0.004419      1.131292      4         11        0.227       1.78618
     2         -0.471003       12.8658       9.67697      0.070322      0.100060      3          0            1       1.78618
     3          0.265495       20.5221       7.65629      0.017792      0.023809      2          0            1      0.595394
     4          0.461465       22.2562       1.73412     -0.000093      0.000161      1          0        0.277      0.198465
     5          0.506281         22.64      0.383727     -0.000007      0.000000      0          0        0.064      0.198465
     6          1.261189       28.5225       5.88253     -0.003385      0.005958      3          0            1      0.198465
     7          2.021159       33.6553       5.13282     -0.003939      0.003035      3          0            1     0.0661549
     8          2.783360       38.2835       4.62819     -0.003724      0.001691      3          0            1     0.0220516
     9          2.877430       38.8266      0.543093     -0.000064      0.000008      1          0        0.127    0.00735054
    10          3.640879       43.0426       4.21604     -0.003950      0.000818      1          0            1    0.00735054
    11          4.404755       46.9752       3.93252     -0.003717      0.000677      1          0            1    0.00245018

 ========== Varying R40 exch downward from 98.04 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.394021       8.16366       8.16366      0.124142      1.365527      5          0         0.26   1.66351e-09
     2         -1.310039       16.5563       8.39267      0.101307      0.330630      3         12            1       14.2895
     3         -0.968802       25.0081       8.45174      0.293736      0.409509      2          0            1       4.76315
     4         -0.514831       31.5431       6.53501      0.383051      0.467465      3          1            1       3.17543
     5         -0.047042       36.3626       4.81952      0.283823      0.392798      5          0            1       2.48493
     6         -0.023926       36.5669      0.204331      0.000026      0.000547      2          0       0.0553       1.39523
     7          0.450343       40.2026        3.6357      0.103709      0.271509     22          0            1       1.39523
     8          1.109807       43.1404       2.93773      0.002560      0.075257     25          0            1      0.465078
     9          1.717258       45.0938       1.95342      0.001893      0.156355     12          0            1      0.155026
    10          1.990823       45.7451      0.651288      0.000049      0.000811      6          0        0.389     0.0516753
    11          2.757877       47.2802       1.53512      0.002041      0.001960      5          0            1     0.0516753
    12          3.526130       48.5566       1.27644      0.001290      0.001069      1          0            1     0.0172251
    13          4.294603       49.6708       1.11422      0.000961      0.000717      1          0            1     0.0057417

 ========== Varying R42 net upward from -68.83 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.009457       2.04045       2.04045      0.666008      1.443736      7          0            1   1.66351e-09
     2          0.227969       2.81011      0.769664      0.008802      0.539668      4          0            1   2.32049e-09
     3          0.995700       3.40193       0.59182      0.002579      0.003140      1          0            1   7.73498e-10
     4          1.763264       3.90361      0.501679      0.001367      0.002094      1          0            1   2.57833e-10
     5          2.530741        4.3473       0.44369      0.000866      0.001681      1          0            1   8.59442e-11
     6          2.904659       4.54766      0.200355      0.000008      0.000000      0          0        0.498   2.86481e-11
     7          3.671274       4.93351      0.385851      0.000986      0.002663      2          0            1   2.86481e-11
     8          4.134494       5.15273       0.21922      0.000024      0.000428      1          0        0.612   9.54935e-12

 ========== Varying R42 net downward from -68.83 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.307032       0.62586       0.62586     -0.013019      1.330014      5          0         0.26   1.66351e-09
     2         -0.548637       1.99008       1.36422      0.153132      0.163028      1          0            1   1.66351e-09
     3         -0.463905       2.08984     0.0997566     -0.000052      0.000025      1          0        0.128   1.30172e-09
     4          0.298195       2.84224      0.752398      0.018110      0.024301      3          0            1   1.30172e-09
     5          1.060783       3.44572      0.603489      0.007717      0.013421      2          0            1   4.33908e-10
     6          1.414544       3.69585      0.250121      0.006754      0.007928      3          0        0.479   1.44636e-10
     7          2.181445       4.18839      0.492549      0.060796      0.062187      3          0            1   1.44636e-10
     8          2.250178       4.22971     0.0413191     -0.000001      0.000000      0          0       0.0938   5.83767e-11
     9          2.429923       4.33592      0.106211      0.000331      0.000423      1          0        0.243   5.83767e-11
    10          3.196949       4.76268      0.426754      0.069787      0.071052      2          0            1   5.83767e-11
    11          3.964037       5.15461      0.391935      0.097510      0.098714      2          0            1   2.63858e-11

 ========== Varying R42 exch upward from 67.55 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.195152       7.08677       7.08677      0.083152      1.401693      7          0        0.376   1.66351e-09
     2         -0.437948        17.752       10.6653      0.401503      0.412591      2          1            1   3.32702e-09
     3          0.324860       24.3037       6.55169      0.023789      0.029272      1          0            1   3.32733e-09
     4          1.089796       29.5186       5.21482      0.003399      0.006754      1          0            1   1.10911e-09
     5          1.855487        33.993       4.47443      0.000900      0.003501      1          0            1   3.69703e-10
     6          2.112222       35.3752       1.38219     -0.000189      0.000051      1          0        0.347   1.23234e-10
     7          2.878482        39.231       3.85586     -0.000434      0.001598      1          0            1   1.23234e-10
     8          3.147759        40.505       1.27396     -0.000165      0.000041      1          0         0.36   4.10781e-11
     9          3.560310       42.3851       1.88012     -0.000577      0.000093      1          0        0.548   4.10781e-11
    10          4.322145        45.657       3.27185     -0.001561      0.004896      3          0            1   4.10781e-11

 ========== Varying R42 exch downward from 67.55 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.171570       10.7879       10.7879      0.384929      1.686845      4          0        0.549   1.66351e-09
     2         -0.571934       19.0377       8.24976      0.118222      0.188840     12         11            1       1.78618
     3          0.129500       25.2186       6.18089      0.214168      0.240647      4          0            1      0.595394
     4          0.832576       30.1157        4.8971      0.095568      0.130962     17          0            1      0.497628
     5          1.545199       34.2906       4.17493      0.034362      0.074459     40          0            1      0.214271
     6          2.318808       37.8697       3.57913      0.006944      0.000831      9          0            1     0.0714236
     7          3.092297       40.7432       2.87344      0.005779      0.000386      5          0            1     0.0238079
     8          3.865477       43.1949       2.45174      0.005103      0.000163      3          0            1    0.00793595

 ========== Varying R44 upward from 62.97 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.105743       4.36805       4.36805      0.066617      1.255213      6          0        0.318   1.66351e-09
     2         -1.042752       5.39237       1.02432     -0.000120      0.000121      1          0        0.114   1.66351e-09
     3         -0.557053       11.2313       5.83888      0.057117      0.060056      1          1        0.699   3.32702e-09
     4          0.175906       17.3916       6.16034     -0.015938      0.019395      1          0            1   3.32702e-09
     5          0.919738       22.1896       4.79802     -0.020510      0.003950      1          0            1   1.10901e-09
     6          1.667830       26.3712       4.18155     -0.018484      0.001716      1          0            1   3.69669e-10
     7          2.418451       30.1893       3.81813     -0.016701      0.000970      1          0            1   1.23223e-10
     8          2.882709       32.4202       2.23092     -0.005887      0.000138      1          0        0.624   4.10744e-11
     9          3.635696       35.8808       3.46057     -0.014609      0.000696      1          0            1   4.10744e-11
    10          4.389896       39.1975       3.31673     -0.013720      0.000372      1          0            1   1.36915e-11

 ========== Varying R44 downward from 62.97 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.396753       4.83172       4.83172      0.087582      1.400596      5          0        0.247   1.66351e-09
     2         -1.343062        9.3724       4.54068      0.099203      0.099540      1          2        0.288   1.33081e-08
     3         -1.139707       14.2201       4.84773      0.077736      0.377796      2         11            1       14.2895
     4         -0.829273        18.626       4.40584      0.166775      0.307251      2          0        0.902       4.76315
     5         -0.452114       22.5583       3.93235      0.202053      0.378932      2          0            1       4.76315
     6          0.002742       26.2579       3.69957      0.537545      0.646662      4          0            1       1.58772
     7          0.411073       28.8555       2.59762      0.097778      0.334923     29          0            1       1.58402
     8          1.123753       30.9911       2.13556      0.022154      0.047627     13          0            1      0.528006
     9          1.845118       32.2634        1.2723      0.008285      0.048513      9          0            1      0.176002
    10          2.611983       33.2638       1.00047      0.005486      0.004679      4          0            1     0.0586674
    11          3.380324       34.1052      0.841355      0.004239      0.003455      2          0            1     0.0195558
    12          4.149021       34.8441      0.738952      0.003609      0.002956      2          0            1     0.0065186

 ========== Varying R46 upward from 101.9 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.904779       2.46572       2.46572      0.002928      1.006191      5          0        0.233   1.66351e-09
     2         -0.143035       5.41891       2.95319     -0.005115      0.001432      1          0            1   1.66351e-09
     3          0.620874       7.55233       2.13342     -0.003402      0.000982      1          0            1   5.54504e-10
     4          0.999638       8.46855      0.916223     -0.000887      0.002537      4          0        0.518   1.84835e-10
     5          1.763497       10.1232        1.6547     -0.003290      0.001143      2          0            1   1.84835e-10
     6          2.527887       11.6021       1.47886     -0.003092      0.000810      2          0            1   6.16115e-11
     7          3.292289       12.9549       1.35279     -0.002952      0.000938      3          0            1   2.05372e-11
     8          3.438106       13.2014      0.246487     -0.000092      0.000043      1          0        0.196   6.84573e-12
     9          4.202842       14.4435       1.24212     -0.002808      0.000748      2          0            1   6.84573e-12

 ========== Varying R46 downward from 101.9 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.359884       4.48332       4.48332      0.144187      2.272362      3          0            1   1.66351e-09
     2         -0.581131       8.30176       3.81844      0.084246      0.073785      2          0            1   1.25805e-09
     3         -0.510470       8.50612      0.204357      0.000031      0.000003      2          0        0.108    6.5945e-10
     4          0.260836       10.3453        1.8392      0.010585      0.007572      1          0            1    6.5945e-10
     5          1.031073       11.7759       1.43062      0.006162      0.004217      1          0            1   2.19817e-10
     6          1.084193       11.8653     0.0893803      0.000010      0.000000      0          0       0.0738   7.32722e-11
     7          1.140801       11.9595     0.0942195      0.000012      0.000029      1          0       0.0786   7.32722e-11
     8          1.910474       13.1465       1.18698      0.004115      0.002734      1          0            1   7.32722e-11
     9          2.679747        14.198       1.05148      0.003478      0.002497      1          0            1   2.44241e-11
    10          3.448719       15.1515      0.953534      0.003113      0.002432      1          0            1   8.14135e-12
    11          3.748199       15.5018      0.350234      0.000225      0.000235      1          0        0.399   2.71378e-12
    12          4.513270       16.3518      0.850036      0.002778      0.002409      2          0        0.995   2.71378e-12

 ========== Varying R47 upward from 1e-07 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.613136       5.99471       5.99471      0.023825      0.690044     14          0        0.289   1.66351e-09
     2          0.148716       8.47339       2.47868     -0.000993      0.005447      1          0            1   1.66351e-09
     3          0.911885       10.4125       1.93907     -0.002621      0.002502      1          0            1   5.54504e-10
     4          1.675687         12.07       1.65758     -0.002648      0.001841      1          0            1   1.84835e-10
     5          2.439875       13.5477       1.47769     -0.002891      0.001212      1          0            1   6.16115e-11
     6          2.540744       13.7324      0.184684     -0.000047      0.000029      1          0        0.137   2.05372e-11
     7          2.643597       13.9185      0.186116     -0.000058      0.000011      1          0        0.139   2.05372e-11
     8          2.764479       14.1346      0.216044     -0.000079      0.000014      1          0        0.163   2.05372e-11
     9          3.529001       15.4409       1.30632     -0.002901      0.000869      2          0            1   2.05372e-11
    10          3.658360       15.6528      0.211885     -0.000085      0.000019      1          0        0.174   6.84573e-12
    11          3.777104       15.8452       0.19241     -0.000071      0.000013      1          0        0.159   6.84573e-12
    12          4.271736       16.6266      0.781362     -0.001201      0.000195      1          0        0.653   6.84573e-12

 ========== Varying R47 downward from 1e-07 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda

 ========== Varying R48 upward from 3.027e-06 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.613136       5.99471       5.99471      0.023298      0.689516     16          0        0.289   1.66351e-09
     2          0.148727       8.47343       2.47872     -0.001029      0.005400      1          0            1   1.66351e-09
     3          0.911896       10.4125       1.93906     -0.002623      0.002501      1          0            1   5.54504e-10
     4          1.675698       12.0701       1.65757     -0.002882      0.001608      1          0            1   1.84835e-10
     5          2.232342       13.1608       1.09073     -0.000716      0.001460      1          0        0.738   6.16115e-11
     6          2.996727       14.5419       1.38113     -0.002906      0.001001      2          0            1   6.16115e-11
     7          3.034014       14.6064     0.0644942     -0.000007      0.000000      0          0       0.0505   2.05372e-11
     8          3.798561       15.8797        1.2733     -0.002864      0.000881      1          0            1   2.05372e-11
     9          4.270792       16.6251      0.745385     -0.001062      0.000209      1          0        0.624   6.84573e-12

 ========== Varying R48 downward from 3.027e-06 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1          0.000000   2.92721e-06   2.92721e-06      0.000000      0.000000      0          0     1.98e-09   1.66351e-09

 ========== Varying R49 upward from 3.026e-06 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.667774       6.45398       6.45398      0.009610      0.710090      3          0        0.153   1.66351e-09
     2          0.082043       9.37511       2.92113     -0.011607      0.006868      1          1            1   3.32702e-09
     3          0.836506       11.7035        2.3284     -0.008646      0.005182      1          0            1   1.10901e-09
     4          1.593013       13.7283       2.02478     -0.010209      0.001577      1          0            1   3.69669e-10
     5          1.629360       13.8201     0.0918392     -0.000022      0.000025      1          0       0.0501   1.23223e-10
     6          1.871801       14.4216      0.601504     -0.000978      0.000064      1          0        0.329   1.23223e-10
     7          2.438282       15.6161       1.19447      0.013554      0.012716      1          0        0.766   1.23223e-10
     8          3.208269        16.887       1.27092      0.027853      0.026158      1          0            1   1.23223e-10
     9          3.247138       16.9444     0.0573684      0.000006      0.000000      0          0       0.0545   4.10744e-11
    10          3.805869       17.7174      0.772971      0.006513      0.005608      1          0        0.741   4.10744e-11
    11          4.576029       18.6595      0.942165      0.016470      0.014603      2          0            1   4.10744e-11

 ========== Varying R49 downward from 3.026e-06 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1          0.000000   2.92567e-06   2.92567e-06      0.000000      0.000000      0          0     2.34e-09   1.66351e-09

 ========== Varying R50 upward from 22.77 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1          0.006954       7.76854       7.76854      0.039787      0.801125     18          0            1   1.66351e-09
     2          0.775665        11.709       3.94043      0.073066      0.072646      1          0            1   5.54504e-10
     3          1.544763       14.5004       2.79148      0.036998      0.036192      2          0            1    2.6004e-10
     4          2.314088        16.785        2.2846      0.025957      0.024923      1          0            1     8.668e-11
     5          2.617787       17.5962      0.811138      0.000894      0.000708      1          0         0.41   2.88933e-11
     6          3.387227        19.484       1.88779      0.020212      0.019063      1          0            1   2.88933e-11
     7          4.156752       21.1863       1.70236      0.018502      0.017269      2          0            1   9.63111e-12

 ========== Varying R50 downward from 22.77 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1          0.000031       22.7695       22.7695      0.000001      0.000000      0          0       0.0152   1.66351e-09

 ========== Varying R51 upward from 3.026e-06 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.283347       16.0301       16.0301      0.003087      1.284103      5          0        0.103   1.66351e-09
     2         -1.397415       25.7447       9.71455      0.000802      0.001234      1          0        0.253   1.66351e-09
     3         -0.647871       33.7246       7.97996      0.300630      0.319378      3          0            1   1.66351e-09
     4          0.118934       37.0555       3.33085      0.048802      0.050289      1          0            1   1.64642e-09
     5          0.200834        37.354      0.298493      0.000029      0.000061      1          0        0.117   5.51144e-10
     6          0.969127       39.8458       2.49183      0.023689      0.023688      1          0            1   5.51144e-10
     7          1.235040       40.6102      0.764344      0.000509      0.000507      1          0        0.362   1.83715e-10
     8          2.003504       42.6228       2.01265      0.020444      0.020272      1          0            1   1.83715e-10
     9          2.772070       44.4162        1.7934      0.021019      0.020745      1          0            1   6.12383e-11
    10          3.540730       46.0482       1.63202      0.021387      0.021019      1          0            1   2.04128e-11
    11          4.309472       47.5547       1.50652      0.022444      0.021993      1          0            1   6.80425e-12

 ========== Varying R51 downward from 3.026e-06 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1          0.000000    2.9262e-06    2.9262e-06      0.000000      0.000000      0          0     1.51e-09   1.66351e-09

 ========== Varying R52 upward from 79.85 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.963711       13.1567       13.1567      0.003740      0.994328     10          0         0.14   1.66351e-09
     2         -0.197928       19.3689       6.21224      0.018464      0.020973      1          0            1   1.66351e-09
     3          0.262380       22.1281       2.75914      0.000209      0.000858      2          0        0.629   5.54504e-10
     4          0.401715       22.8864      0.758279     -0.000036      0.000028      1          0        0.196   5.54504e-10
     5          0.502963       23.4195      0.533116     -0.000018      0.000005      1          0        0.143   5.54504e-10
     6          1.268923       27.0672       3.64775     -0.001565      0.000767      2          0            1   5.54504e-10
     7          1.651677       28.6951       1.62785     -0.000433      0.000072      1          0        0.515   1.84835e-10
     8          2.374785       31.4438       2.74875     -0.001941      0.043242      4          0            1   1.84835e-10
     9          3.141580       34.0166       2.57281     -0.000301      0.001197      3          0            1   6.16115e-11
    10          3.206123        34.221      0.204312     -0.000004      0.000000      0          0       0.0878   2.05372e-11
    11          3.283907       34.4644      0.243492     -0.000000      0.000000      0          0        0.107   2.05372e-11
    12          4.042547       36.7144       2.24998      0.000603      0.010254      2          0            1   2.05372e-11

 ========== Varying R52 downward from 79.85 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.000008       79.8544       79.8544      0.000000      0.000000      0          0        0.054   1.66351e-09

 ========== Varying R53 upward from 3.027e-06 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1          0.000000       79.8544       79.8544      0.000000      0.000000      0          0        0.054   1.66351e-09
     2         -0.957485        93.011       13.1567      0.005391      0.989754      6          0         0.14   1.66351e-09
     3         -0.192302       99.1597       6.14865      0.006865      0.009974      1          0            1   1.66351e-09
     4          0.550266       103.518       4.35842     -0.000100      0.025623      5          0            1   5.54504e-10
     5          1.316267       107.129       3.61076     -0.001332      0.000960      2          0            1   1.84835e-10
     6          1.650589       108.545       1.41608     -0.000331      0.000052      1          0        0.451   6.16115e-11
     7          2.373659       111.294       2.74922     -0.001942      0.043280      4          0            1   6.16115e-11
     8          2.478424       111.663       0.36923     -0.000003      0.000000      0          0        0.143   2.05372e-11
     9          2.567237       111.972      0.308103     -0.000004      0.000000      0          0        0.122   2.05372e-11
    10          2.854267        112.94      0.968561     -0.000046      0.000401      2          0        0.387   2.05372e-11
    11          3.187095       114.015       1.07519     -0.000083      0.000255      2          0        0.446   2.05372e-11
    12          3.894524       116.143       2.12781      0.000459      0.006408      2          0        0.932   2.05372e-11

 ========== Varying R53 downward from 3.027e-06 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1          0.000000   2.92727e-06   2.92727e-06      0.000000      0.000000      0          0     1.98e-09   1.66351e-09

 ========== Varying R54 upward from 6.23 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.924522      0.807629      0.807629     -0.004742      1.109029      4          0        0.484   1.66351e-09
     2         -0.200162       1.70465      0.897025     -0.040497      0.003434      1          0            1   1.66351e-09
     3          0.539418       2.40963      0.704972     -0.027760      0.000952      1          0            1   5.54504e-10
     4          0.975269       2.77916      0.369536     -0.007628      0.000157      1          0        0.598   1.84835e-10
     5          1.326073        3.0603      0.281136     -0.004449      0.000090      1          0         0.48   1.84835e-10
     6          2.076471       3.61048      0.550184     -0.014971      0.000264      1          0        0.997   1.84835e-10
     7          2.129526       3.64696     0.0364811     -0.000063      0.000001      1          0       0.0734   1.84835e-10
     8          2.885016       4.14067      0.493711     -0.012575      0.000226      1          0            1   1.84835e-10
     9          3.642063       4.59739      0.456711     -0.011023      0.000222      1          0            1   6.16115e-11
    10          4.400231       5.02669      0.429303     -0.009970      0.000154      2          0            1   2.05372e-11

 ========== Varying R54 downward from 6.23 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.397447       0.63167       0.63167      0.003764      1.403229      6          0         0.13   1.66351e-09
     2         -0.486830       2.03851       1.40684      0.162542      0.020216      4          0            1   1.66351e-09
     3          0.057223       2.36785      0.329343      0.015017      0.000569      3          0         0.72   1.34416e-09
     4          0.850437       2.72991      0.362052      0.025426      0.000504      1          0            1   1.34416e-09
     5          1.639169       3.01457      0.284667      0.020932      0.000492      1          0            1   4.48053e-10
     6          2.425326       3.25197      0.237393      0.018372      0.000507      1          0            1   1.49351e-10
     7          3.209745        3.4567      0.204733      0.016683      0.000556      1          0            1   4.97836e-11
     8          3.992862       3.63718      0.180482      0.015461      0.000635      2          0            1   1.65945e-11

 ========== Varying R55 upward from 43.52 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.986862       3.29732       3.29732      0.004052      1.084224      5          0        0.343   1.66351e-09
     2         -0.249138       7.92256       4.62524     -0.027257      0.003311      2          0            1   1.66351e-09
     3         -0.055098       8.88574      0.963173     -0.001281      0.000059      1          0         0.28   5.54504e-10
     4          0.694845       12.1554       3.26969     -0.017338      0.001011      2          0            1   5.54504e-10
     5          1.457529       14.8478       2.69242     -0.005135      0.000472      1          0            1   1.84835e-10
     6          2.221289          17.1       2.25219     -0.004163      0.000369      1          0            1   6.16115e-11
     7          2.622941       18.1694        1.0694     -0.001016      0.000071      1          0        0.539   2.05372e-11
     8          3.386498       20.0473       1.87791     -0.003396      0.001339      1          0            1   2.05372e-11
     9          4.150104        21.791       1.74363     -0.004357      0.000329      1          0            1   6.84573e-12

 ========== Varying R55 downward from 43.52 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.397412       4.11077       4.11077      0.003673      1.406765      5          0        0.129   1.66351e-09
     2         -0.579835       11.3004       7.18959      0.054713      0.005427      1          0            1   1.66351e-09
     3          0.199196       14.0677        2.7673      0.011212      0.000473      1          0            1    6.1435e-10
     4          0.975008       16.1545       2.08681      0.007913      0.000392      2          0            1   2.04783e-10
     5          1.059156       16.3567      0.202242      0.000076      0.000006      1          0        0.117   6.82611e-11
     6          1.833339       18.0613       1.70464      0.006359      0.000468      1          0            1   6.82611e-11
     7          2.606044       19.5495       1.48819      0.005367      0.000954      2          0            1   2.27537e-11
     8          2.858489       20.0007      0.451178      0.000489      0.000077      1          0        0.338   7.58457e-12
     9          3.630395       21.2949       1.29417      0.004383      0.000769      1          0            1   7.58457e-12
    10          4.308702       22.3437       1.04882      0.003006      0.000616      2          0        0.883   2.52819e-12

 ========== Varying R56 upward from 1e-07 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1          0.015251        7.8243        7.8243      0.140141      0.585113     16          0        0.817   1.66351e-09
     2         -0.604651       11.7432       3.91892      0.070854      1.459049      5          0            1   1.66351e-09
     3         -0.377903       20.3502       8.60694      0.290921      0.832465      3          0            1   7.61145e-10
     4         -0.410362       26.2359       5.88571      0.190399      0.991150      3          1            1   1.50053e-09
     5         -0.325885       27.5987       1.36285      0.000609      0.000616      2          0        0.215   1.30802e-09
     6          0.442061        32.991        5.3923      0.149821      0.150166      1          0            1   1.30802e-09
     7          1.210961       36.1402       3.14921      0.047143      0.046535      1          0            1   1.01114e-09
     8          1.493037       37.1015       0.96128      0.000901      0.000778      1          0        0.389   3.37046e-10
     9          1.545975       37.2739      0.172377      0.000007      0.000000      0          0       0.0746   3.37046e-10
    10          2.315232       39.5577       2.28381      0.026327      0.025363      1          0            1   3.37046e-10
    11          3.084689       41.5366       1.97894      0.021587      0.020422      1          0            1   1.12349e-10
    12          3.854226       43.3054       1.76877      0.018959      0.017714      1          0            1   3.74495e-11

 ========== Varying R56 downward from 1e-07 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda

 ========== Varying R57 upward from 3.026e-06 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.252589       6.39236       6.39236      0.010432      1.245452      6          0        0.172   1.66351e-09
     2         -0.571178       7.51738       1.12502     -0.059124      0.027757      2          0            1   1.66351e-09
     3         -0.459966       7.64912      0.131745     -0.000773      0.000009      1          0        0.169   5.54504e-10
     4          0.276171       8.40228      0.753156     -0.023403      0.008752      1          0            1   5.54504e-10
     5          0.765981        8.8348      0.432523     -0.010365      0.000217      1          0        0.672   1.84835e-10
     6          0.801687       8.86493     0.0301274     -0.000047      0.000012      1          0       0.0502   1.84835e-10
     7          1.397112        9.3456      0.480667     -0.013302      0.000213      1          0        0.804   1.84835e-10
     8          2.150322       9.89207      0.546472     -0.014836      0.000246      1          0            1   1.84835e-10
     9          2.905852       10.3852      0.493153     -0.012569      0.000192      1          0            1   6.16115e-11
    10          3.662922       10.8416       0.45636     -0.011054      0.000168      1          0            1   2.05372e-11
    11          4.421107       11.2707       0.42908     -0.009952      0.000155      1          0            1   6.84573e-12

 ========== Varying R57 downward from 3.026e-06 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1          0.000000   2.92596e-06   2.92596e-06     -0.000000      0.000000      0          0     7.67e-08   1.66351e-09

 ========== Varying R58 upward from 3.025e-06 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.664946       12.9423       12.9423      0.034527      0.781309     15          0        0.365   1.66351e-09
     2         -0.352705       15.5258       2.58354      0.002876      0.004460      1          0        0.452   1.66351e-09
     3          0.420796       18.6013        3.0755      0.276583      0.271374      1          0            1   1.66351e-09
     4          1.192182       20.3514       1.75009      0.093049      0.089955      2          0            1   1.62699e-09
     5          1.314330       20.5861      0.234676      0.000150      0.000073      2          0        0.172   9.19034e-10
     6          2.085762       21.9067       1.32065      0.054327      0.051187      1          0            1   9.19034e-10
     7          2.232489       22.1332      0.226411      0.000241      0.000126      1          0        0.201   3.37374e-10
     8          2.571771        22.633      0.499873      0.055398      0.054804      1          0        0.456   3.37374e-10
     9          3.342978       23.6696       1.03654      0.038995      0.036079      2          0            1   3.37374e-10
    10          3.436996        23.788      0.118453      0.000081      0.000082      1          0        0.127   1.12458e-10
    11          3.902078       24.3527      0.564698      0.005934      0.004896      2          0        0.615   1.12458e-10

 ========== Varying R58 downward from 3.025e-06 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.000000   2.92548e-06   2.92548e-06      0.000000      0.000000      0          0     2.01e-09   1.66351e-09

 ========== Varying R59 upward from 3.026e-06 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.364619       10.1547       10.1547      0.049352      1.073736     16          0        0.883   1.66351e-09
     2          0.400706        13.434       3.27931      0.000274      0.003241      1          0            1   1.66351e-09
     3          0.828249       14.9667       1.53267     -0.000496      0.000322      1          0        0.579   5.54504e-10
     4          1.281354       16.2318       1.26511      0.022350      0.020322      1          0        0.643   5.54504e-10
     5          1.913703       17.5299       1.29816      0.044052      0.040671      1          0        0.839   5.54504e-10
     6          2.686706       18.7776       1.24768      0.055503      0.050791      1          0            1   5.54504e-10
     7          3.459587       19.8174       1.03975      0.043711      0.039123      1          0            1   2.07296e-10
     8          3.540786       19.9181      0.100707      0.000081      0.000054      1          0        0.111   6.90986e-11
     9          4.313144       20.8123      0.894222      0.035818      0.031751      3          0            1   6.90986e-11

 ========== Varying R59 downward from 3.026e-06 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1          0.000000   2.92578e-06   2.92578e-06      0.000000      0.000000      0          0     2.06e-09   1.66351e-09

 ========== Varying R61 upward from 2.122e-06 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.657176       3.04478       3.04478      0.029867      0.768649      4          0        0.274   1.66351e-09
     2          0.107748       4.35475       1.30997      0.001785      0.005152      1          0            1   1.66351e-09
     3          0.873110       5.36292       1.00817     -0.000767      0.002163      1          0            1   5.54504e-10
     4          1.638671       6.21717      0.854251     -0.001343      0.001387      1          0            1   1.84835e-10
     5          2.404354       6.97401       0.75684     -0.001569      0.001040      1          0            1   6.16115e-11
     6          2.541619       7.10183      0.127824     -0.000059      0.000028      1          0        0.186   2.05372e-11
     7          3.307397       7.77974      0.677901     -0.001735      0.000779      1          0            1   2.05372e-11
     8          3.634940       8.05394      0.274207     -0.000326      0.000122      1          0        0.436   6.84573e-12
     9          4.400804       8.66479      0.610848     -0.001756      0.000672      1          0            1   6.84573e-12

 ========== Varying R61 downward from 2.122e-06 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1          0.000000   2.02222e-06   2.02222e-06      0.000000      0.000000      0          0     2.04e-09   1.66351e-09

 ========== Varying R62 upward from 3.025e-06 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.665163       6.24884       6.24884      0.013985      0.732186      3          0        0.208   1.66351e-09
     2          0.095797       8.98697       2.73813     -0.000137      0.007195      1          0            1   1.66351e-09
     3          0.858699       11.1086       2.12166     -0.003399      0.001990      1          0            1   5.54504e-10
     4          1.622226       12.9162       1.80757     -0.003401      0.001364      1          0            1   1.84835e-10
     5          1.705761       13.1005      0.184328     -0.000042      0.000025      1          0        0.115   6.16115e-11
     6          2.469690       14.6919       1.59139     -0.003392      0.000970      1          0            1   6.16115e-11
     7          2.540261       14.8315      0.139601     -0.000028      0.000026      2          0       0.0958   2.05372e-11
     8          2.686591       15.1174       0.28586     -0.000122      0.000023      1          0        0.198   2.05372e-11
     9          3.456763       16.4257       1.30832      0.024481      0.022601      1          0            1   2.05372e-11
    10          4.101746       17.3317      0.906019      0.009306      0.007959      1          0        0.848   6.84573e-12

 ========== Varying R62 downward from 3.025e-06 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1          0.000000   2.92548e-06   2.92548e-06     -0.000000      0.000000      0          0     2.06e-09   1.66351e-09

 ========== Varying R64 upward from 32.79 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.394582       1.66372       1.66372      0.013316      1.427664      5          0        0.198   1.66351e-09
     2         -1.351519       2.66848       1.00475      0.000955      0.000558      1          0        0.194   1.66351e-09
     3         -1.139757       3.45663      0.788153      0.029678      0.044688      4          0        0.494   1.66351e-09
     4         -0.370256       4.51215       1.05552      0.152511      0.151302      3          0            1   1.66351e-09
     5          0.400165       5.18017      0.668016      0.049775      0.047645      2          0            1    1.2988e-09
     6          1.170075       5.70964      0.529467      0.037999      0.036380      3          0            1   4.42275e-10
     7          1.940041       6.16143      0.451795      0.021949      0.020275      5          0            1   1.47425e-10
     8          2.709118       6.56131      0.399874      0.017565      0.016780     10          0            1   4.91417e-11
     9          3.355098       6.86804      0.306731      0.008093      0.007764     21          0        0.846   1.63806e-11
    10          4.124357       7.20644      0.338406      0.012872      0.011905      3          0            1   1.63806e-11

 ========== Varying R64 downward from 32.79 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.602117      0.907917      0.907917      0.005049      1.142436      5          0        0.748   1.66351e-09
     2          0.103982       1.82062      0.912706     -0.004414      0.057779      2          0            1   1.66351e-09
     3          0.176637       1.89771     0.0770907     -0.000040      0.000017      1          0        0.104   5.54504e-10
     4          0.472755       2.19565      0.297939     -0.000644      0.000044      1          0         0.41   5.54504e-10
     5          1.193579       2.81642      0.620764     -0.000878      0.046591      3          0            1   5.54504e-10
     6          1.395299       2.97417      0.157755     -0.000182      0.000088      1          0        0.276   1.84835e-10
     7          2.160667       3.52823      0.554055     -0.002537      0.000386      2          0            1   1.84835e-10
     8          2.926252        4.0285      0.500274     -0.002327      0.000380      2          0            1   6.16115e-11
     9          3.611862       4.44238      0.413879     -0.001774      0.000269      1          0        0.899   2.05372e-11
    10          3.711377       4.50022     0.0578353     -0.000036      0.000006      1          0        0.134   2.05372e-11
    11          4.477249       4.92907      0.428858      0.021268      0.023688      1          0            1   2.05372e-11

 ========== Varying R65 upward from 1e-07 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.727791       4.32434       4.32434     -0.000464      0.751318      4          0        0.156   1.66351e-09
     2          0.034961       6.35969       2.03535     -0.002760      0.002780      1          0            1   1.66351e-09
     3          0.798957       7.91055       1.55085     -0.003172      0.001124      1          0            1   5.54504e-10
     4          1.563490       9.22115       1.31061     -0.002488      0.001270      1          0            1   1.84835e-10
     5          2.328343       10.3814       1.16027     -0.002761      0.000678      1          0            1   6.16115e-11
     6          2.458994       10.5682      0.186742     -0.000078      0.000022      1          0        0.177   2.05372e-11
     7          3.224130       11.6081       1.03998     -0.002549      0.000607      1          0            1   2.05372e-11
     8          3.989394       12.5726      0.964406     -0.002467      0.000561      1          0            1   6.84573e-12

 ========== Varying R65 downward from 1e-07 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda

 ========== Varying R66 upward from 1e-07 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.727454       4.32432       4.32432     -0.000488      0.750957      4          0        0.156   1.66351e-09
     2          0.034884       6.35952        2.0352     -0.001672      0.004282      2          0            1   1.66351e-09
     3          0.798906       7.91044       1.55092      0.009894      0.014165      1          0            1   5.54504e-10
     4          1.563423       9.22105       1.31061     -0.002945      0.000829      1          0            1   1.84835e-10
     5          1.859253       9.68465      0.463599     -0.000429      0.000091      1          0          0.4   6.16115e-11
     6          2.624225       10.8002       1.11557     -0.002699      0.000621      1          0            1   6.16115e-11
     7          2.971082       11.2736      0.473348     -0.000521      0.000132      1          0        0.463   2.05372e-11
     8          3.476713       11.9339      0.660364     -0.001061      0.000273      1          0        0.669   2.05372e-11
     9          4.242034       12.8772      0.943263     -0.002435      0.000536      1          0            1   2.05372e-11

 ========== Varying R66 downward from 1e-07 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda

 ========== Varying R70 upward from 32.79 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.395681       1.56166       1.56166      0.010551      1.340063      8          0        0.153   1.66351e-09
     2         -1.351503       2.66869       1.10703      0.001015      0.000890      1          0         0.21   1.66351e-09
     3         -0.585168       4.27565       1.60697      0.398886      0.400843      1          0            1   1.66351e-09
     4          0.183017       4.99368      0.718025      0.048503      0.048610      1          0            1   1.66361e-09
     5          0.280094       5.06981     0.0761322      0.000021      0.000015      1          0        0.138   5.54535e-10
     6          1.048782       5.60583      0.536015      0.020237      0.019841      1          0            1   5.54535e-10
     7          1.210081        5.7067      0.100875      0.000093      0.000072      1          0        0.222   1.84845e-10
     8          1.978609       6.14816      0.441458      0.013313      0.013077      2          0            1   1.84845e-10
     9          2.746687       6.54042      0.392261      0.011086      0.011300      5          0            1    6.1615e-11
    10          2.833598       6.58239     0.0419663      0.000021      0.000015      1          0        0.118   2.05383e-11
    11          2.882274       6.60569      0.023305      0.000003      0.000000      0          0        0.066   2.05383e-11
    12          3.650402       6.95709      0.351396      0.008621      0.008784     10          0            1   2.05383e-11
    13          4.418786       7.28245      0.325359      0.007614      0.007522     14          0            1   6.84611e-12

 ========== Varying R70 downward from 32.79 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.704395       3.01461       3.01461      0.000553      0.742103      4          0         0.16   1.66351e-09
     2          0.057073       5.00949       1.99488     -0.005283      0.001541      1          0            1   1.66351e-09
     3          0.219755       5.36318      0.353689     -0.000213      0.000015      1          0        0.231   5.54504e-10
     4          0.983239       6.83473       1.47154     -0.004351      0.000457      1          0            1   5.54504e-10
     5          1.747382       8.09828       1.26356     -0.003768      0.000381      1          0            1   1.84835e-10
     6          1.894513       8.32452      0.226233     -0.000126      0.000014      1          0          0.2   6.16115e-11
     7          1.936851       8.38875     0.0642337     -0.000010      0.000001      1          0        0.058   6.16115e-11
     8          2.701499       9.49074       1.10199     -0.003313      0.000331      1          0            1   6.16115e-11
     9          3.466398        10.503       1.01225     -0.003059      0.000334      1          0            1   2.05372e-11
    10          3.656328        10.743      0.239989     -0.000177      0.000024      1          0        0.254   6.84573e-12
    11          3.698727        10.796     0.0530177     -0.000009      0.000000      0          0       0.0571   6.84573e-12
    12          4.463852       11.7212      0.925224     -0.002816      0.000351      1          0            1   6.84573e-12

 ========== Varying R71 upward from 6.23 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -0.069368       1.26549       1.26549     -0.035743      0.801912      4          0            1   1.66351e-09
     2         -0.067413       1.55398       0.28849     -0.002536      0.212515      2          0        0.343   5.54504e-10
     3          0.675943       2.18748      0.633501     -0.024050      0.000886      1          0            1   5.54504e-10
     4          1.424092       2.74677      0.559291     -0.019516      0.000626      1          0            1   1.84835e-10
     5          1.920624       3.09056      0.343788     -0.007305      0.000241      1          0        0.669   6.16115e-11
     6          2.155517        3.2474      0.156834     -0.001507      0.000014      1          0        0.319   6.16115e-11
     7          2.912045       3.72154      0.474146     -0.011534      0.000230      2          0            1   6.16115e-11
     8          3.670074       4.15741      0.435868     -0.010075      0.000187      1          0            1   2.05372e-11
     9          4.404953       4.55253      0.395121     -0.008462      0.024950      2          0            1   6.84573e-12

 ========== Varying R71 downward from 6.23 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1         -1.356330       6.22992       6.22992      0.010698      1.364524      5          0        0.179   1.66351e-09

 ========== Varying R72 upward from 22.04 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1          0.768292     0.0410863     0.0410863      0.000000      0.000000      0          0            1   1.66351e-09
     2          1.536584     0.0580622     0.0169759      0.000000      0.000000      0          0            1   5.54504e-10
     3          2.304875     0.0710883     0.0130261      0.000000      0.000000      0          0            1   1.84835e-10
     4          3.073167     0.0820698     0.0109815      0.000000      0.000000      0          0            1   6.16115e-11
     5          3.841459     0.0917447    0.00967489      0.000000      0.000000      0          0            1   2.05372e-11

 ========== Varying R72 downward from 22.04 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1          0.768292      0.040878      0.040878      0.000000      0.000000      0          0            1   1.66351e-09
     2          1.536584     0.0578539     0.0169759      0.000000      0.000000      0          0            1   5.54504e-10
     3          2.304875       0.07088     0.0130261      0.000000      0.000000      0          0            1   1.84835e-10
     4          3.073167     0.0818615     0.0109815      0.000000      0.000000      0          0            1   6.16115e-11
     5          3.841459     0.0915364    0.00967489      0.000000      0.000000      0          0            1   2.05372e-11

 ========== Varying ex_3 upward from 108.8 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1          0.768292      0.201081      0.201081     -0.000000      0.000000      0          0            1   1.66351e-09
     2          1.536583      0.284889     0.0838084     -0.000000      0.000000      0          0            1   5.54504e-10
     3          2.304875      0.349198     0.0643088     -0.000000      0.000000      0          0            1   1.84835e-10
     4          3.073167      0.403413      0.054215     -0.000000      0.000000      0          0            1   6.16115e-11
     5          3.841459      0.451177     0.0477644     -0.000000      0.000000      0          0            1   2.05372e-11
     6          4.609750       0.49436     0.0431824      0.000000      0.000000      0          0            1   6.84573e-12

 ========== Varying ex_3 downward from 108.8 ==========

                Delta        Delta                       Predictor    Corrector   Corrector   Failed
 Iteration      residual     parameter     Step-size         error    adjustment  iterations   steps     h/hopt        Lambda
     1          0.768291      0.202866      0.202866     -0.000001      0.000000      0          0            1   1.66351e-09
     2          1.536583      0.286673     0.0838076     -0.000000      0.000000      0          0            1   5.54504e-10
     3          2.304875      0.350981     0.0643079      0.000001      0.000000      0          0            1   1.84835e-10
     4          3.073167      0.405195     0.0542141     -0.000000      0.000000      0          0            1   6.16115e-11
     5          3.841459      0.452959     0.0477635     -0.000000      0.000000      0          0            1   2.05372e-11
     6          4.609750       0.49614     0.0431815      0.000000      0.000000      0          0            1   6.84573e-12

        Continuation completed in 261.2500 seconds.

        Preprocessing time:     1.3600 s

        Computation time:       259.8900 s
Warning: Network is ill-conditioned.

        Simulation completed in 0.6800 seconds.

        Preprocessing time:     0.5300 s

        Computation time:       0.0800 s

        Postprocessing time:    0.0700 s

--- 196.37572407722473 seconds -

Now we can read in the fit and validate that the INCAWrapper was able to find the true simulated fluxes.

[9]:
# read in the fitted fluxes
res = incawrapper.INCAResults(results_file)

# get the goodness of fit
res.fitdata.get_goodness_of_fit()
Fit accepted: False
Confidence level: 0.05
Chi-square value (SSR): 1.3975152924359795
Expected chi-square range: [ 77.6721744  134.11116275]

The SSR is very small which indicate over-fitting, however this is expected because this is simulated data without any measurement error or bias’.

We can now load the true flux distribution and compare the to fitted. The true (simulated) flux distribution has some very small values, these are rounded as they cause some issues in the comparison.

[10]:
true_fluxes = (pd.read_csv(data_directory / 'true_fluxes.csv')
    .round(6)
)
[11]:
# combines the fitted and true fluxes
true_and_fitted_fluxes = pd.merge(
    res.fitdata.fitted_parameters.query("type.str.contains('flux')"),
    true_fluxes.rename(columns={"rxn_id": "id", "flux": "val"}),
    on="id",
    suffixes=("_fitted", "_true"),
).fillna({
    "lb" : -np.inf,
    "ub" : np.inf
})

INCA is not able to make an exact match to the true fluxes because there are to few measurements. Therefore, we will check fraction of the true fluxes are within the estimated upper and lower bounds.

[12]:
def is_in_interval(x, lb, ub):
    return (x >= lb) & (x <= ub)

# few tests to validate function
assert is_in_interval(4.5,-np.inf,10) == True
assert is_in_interval(4.5,0,10) == True
assert is_in_interval(10,0,4.5) == False

true_vals_in_interval = true_and_fitted_fluxes.apply(
    lambda x: is_in_interval(x['val_true'], x['lb'], x['ub']), axis=1
)

fraction_correct_fluxes = true_vals_in_interval.sum() / true_vals_in_interval.size
fraction_correct_fluxes
[12]:
1.0

We can also vizualize the fitted and true fluxes. Note that some fluxes have very large bounds, we these are truncated for visualization purposes.

[13]:
yaxis_range = [-250, 400]
plot_df = true_and_fitted_fluxes.copy()
# replace inf with large number
plot_df['lb'].replace(np.inf, yaxis_range[0], inplace=True)
plot_df['ub'].replace(np.inf, yaxis_range[1], inplace=True)
fig, ax = plt.subplots(figsize=(10, 5))
errbars = plot_df[['lb', 'ub']].subtract(plot_df['val_fitted'], axis=0).abs().T
ax.scatter(x=plot_df['id'], y=plot_df['val_fitted'], color='black', label='fitted value')
ax.errorbar(x=plot_df['id'], y=plot_df['val_fitted'], yerr=errbars, color='black', fmt='none', label='95% CI of fitted value')
ax.scatter(x=plot_df['id'], y=plot_df['val_true'], color='red', label='literature value', s=8)
# rotate x-axis labels
ax.tick_params(axis='x', labelrotation=90)
ax.legend()
ax.set_ylim(yaxis_range)
[13]:
(-250.0, 400.0)
../_images/examples_c_necator_simulated_data_18_1.png

We see that most of the true flux value lies close to the estimated flux value. However, some of the flux estimates have large uncertainties. Therefor, we investigate how many fluxes are “well determined”.

[14]:
def well_determined_fluxes(val, lb, ub, cutoff):
    '''Finds well defined fluxes, these are fluxes where the relative uncertainty span is less than the cutoff.'''
    if val == 0:
        return (ub - lb) < cutoff
    relative_uncertainty_span = (ub - lb) / np.abs(val)
    return relative_uncertainty_span < cutoff

assert well_determined_fluxes(1, 0.9, 1.1, 0.21) == True
assert well_determined_fluxes(1, 0.9, 1.1, 0.1) == False
assert well_determined_fluxes(0, -0.49, 0.49, 1) == True
[15]:
true_and_fitted_fluxes['well_determined'] = true_and_fitted_fluxes.apply(
    lambda x: well_determined_fluxes(x['val_true'], x['lb'], x['ub'], 1), axis=1
)
true_and_fitted_fluxes['well_determined'].sum() / true_and_fitted_fluxes['well_determined'].size
[15]:
0.37333333333333335

We see that only 37% of the fluxes are well determined using a cutoff=1. This shows that the simulated experiments do not contain sufficient information about the flux distribution to gain an accurate estimate. This could likely be improve by introducing more simulated parallel experiments, using other labelled substrates. However, some fluxes, e.g. the exchange flux of reversible reactions, can be difficult to estimate at all.

We will calculate the fraction of well determined net fluxes

[23]:
net_fluxes = true_and_fitted_fluxes['type'] == 'Net flux'
true_and_fitted_fluxes.loc[net_fluxes, 'well_determined'].sum() / net_fluxes.sum()
[23]:
0.45

This is still not super impressive, however, visual inspection of the plot shows that the flux estimate is in good agreement with the simulated flux distribution. We strongly believe that this performance is due lack of information in the simulated data, rather that errors in the INCAWrapper.

Finally, we have a few tests which validates that the analysis was consistent with earlier runs for testing purposes.

[24]:
## Setup validation tests that test that the results are similar to the previous run
# Test that the fraction of correct fluxes similar to ealier run
assert fraction_correct_fluxes == 1.0

# Test that the chi2 is similar to ealier run, this test may be fragile because the flux
# estimation is stochastic. Therefore, we only test that the chi2 very small (i.e. < 5).
assert res.fitdata.chi2 < 5

# Test that the fraction of well determined fluxes is similar to ealier run
assert true_and_fitted_fluxes['well_determined'].sum() / true_and_fitted_fluxes['well_determined'].size == pytest.approx(0.373, 0.005)
assert true_and_fitted_fluxes.loc[net_fluxes, 'well_determined'].sum() / net_fluxes.sum() == pytest.approx(0.45, 0.005)